{"id":"https://openalex.org/W2188305878","doi":null,"title":"The expression and functional evidence for voltage-dependent potassium channel Kv1.3 in lymphocytes during aging in spontaneously hypertensive rats.","display_name":"The expression and functional evidence for voltage-dependent potassium channel Kv1.3 in lymphocytes during aging in spontaneously hypertensive rats.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2188305878","mag":"2188305878","pmid":"https://pubmed.ncbi.nlm.nih.gov/25932196","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4402843"},"language":"en","primary_location":{"id":"pmid:25932196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25932196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4402843/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040430409","display_name":"Lingpeng Wang","orcid":"https://orcid.org/0009-0003-9310-7682","observed_orcids":["https://orcid.org/0009-0003-9310-7682"]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]},{"id":"https://openalex.org/I2802734952","display_name":"First Affiliated Hospital of Xinjiang Medical University","ror":"https://ror.org/02qx1ae98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802734952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling-Peng Wang","raw_affiliation_strings":["Department of Cardiology of The First Affiliated Hospital, Xinjiang Medical University Urumqi 830000, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology of The First Affiliated Hospital, Xinjiang Medical University Urumqi 830000, Xinjiang, China","institution_ids":["https://openalex.org/I154093214","https://openalex.org/I2802734952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065602990","display_name":"Jian Luo","orcid":"https://orcid.org/0000-0001-8841-0458","observed_orcids":["https://orcid.org/0000-0001-8841-0458"]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]},{"id":"https://openalex.org/I2802734952","display_name":"First Affiliated Hospital of Xinjiang Medical University","ror":"https://ror.org/02qx1ae98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802734952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Luo","raw_affiliation_strings":["Department of Internal Medicine (VIP) of The First Affiliated Hospital, Xinjiang Medical University Urumqi 830000, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine (VIP) of The First Affiliated Hospital, Xinjiang Medical University Urumqi 830000, Xinjiang, China","institution_ids":["https://openalex.org/I154093214","https://openalex.org/I2802734952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103903722","display_name":"Haifeng Hu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hai-Feng Hu","raw_affiliation_strings":["Department of Heart and Renal of The Sixth People's Hospital in Xinjiang Uygur Autonomous Region Urumqi 830000, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Heart and Renal of The Sixth People's Hospital in Xinjiang Uygur Autonomous Region Urumqi 830000, Xinjiang, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]},{"id":"https://openalex.org/I2802734952","display_name":"First Affiliated Hospital of Xinjiang Medical University","ror":"https://ror.org/02qx1ae98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802734952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Zhang","raw_affiliation_strings":["Department of Internal Medicine (VIP) of The First Affiliated Hospital, Xinjiang Medical University Urumqi 830000, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine (VIP) of The First Affiliated Hospital, Xinjiang Medical University Urumqi 830000, Xinjiang, China","institution_ids":["https://openalex.org/I154093214","https://openalex.org/I2802734952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100346263","display_name":"Yali Li","orcid":"https://orcid.org/0000-0002-4863-5713","observed_orcids":["https://orcid.org/0000-0002-4863-5713"]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]},{"id":"https://openalex.org/I2802734952","display_name":"First Affiliated Hospital of Xinjiang Medical University","ror":"https://ror.org/02qx1ae98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802734952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya-Li Li","raw_affiliation_strings":["Department of Internal Medicine (VIP) of The First Affiliated Hospital, Xinjiang Medical University Urumqi 830000, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine (VIP) of The First Affiliated Hospital, Xinjiang Medical University Urumqi 830000, Xinjiang, China","institution_ids":["https://openalex.org/I154093214","https://openalex.org/I2802734952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066439582","display_name":"Li-Man Ai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]},{"id":"https://openalex.org/I2802734952","display_name":"First Affiliated Hospital of Xinjiang Medical University","ror":"https://ror.org/02qx1ae98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802734952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Man Ai","raw_affiliation_strings":["Department of Cardiology of The First Affiliated Hospital, Xinjiang Medical University Urumqi 830000, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology of The First Affiliated Hospital, Xinjiang Medical University Urumqi 830000, Xinjiang, China","institution_ids":["https://openalex.org/I154093214","https://openalex.org/I2802734952"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yu-Ling Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]},{"id":"https://openalex.org/I2802734952","display_name":"First Affiliated Hospital of Xinjiang Medical University","ror":"https://ror.org/02qx1ae98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802734952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Ling Wang","raw_affiliation_strings":["Department of Internal Medicine (VIP) of The First Affiliated Hospital, Xinjiang Medical University Urumqi 830000, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine (VIP) of The First Affiliated Hospital, Xinjiang Medical University Urumqi 830000, Xinjiang, China","institution_ids":["https://openalex.org/I154093214","https://openalex.org/I2802734952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100720814","display_name":"Yitong Ma","orcid":"https://orcid.org/0009-0002-1445-1817","observed_orcids":["https://orcid.org/0009-0002-1445-1817"]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]},{"id":"https://openalex.org/I2802734952","display_name":"First Affiliated Hospital of Xinjiang Medical University","ror":"https://ror.org/02qx1ae98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802734952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Tong Ma","raw_affiliation_strings":["Department of Cardiology of The First Affiliated Hospital, Xinjiang Medical University Urumqi 830000, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology of The First Affiliated Hospital, Xinjiang Medical University Urumqi 830000, Xinjiang, China","institution_ids":["https://openalex.org/I154093214","https://openalex.org/I2802734952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103679560","display_name":"Hu-Yati Mu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]},{"id":"https://openalex.org/I2802734952","display_name":"First Affiliated Hospital of Xinjiang Medical University","ror":"https://ror.org/02qx1ae98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802734952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hu-Yati Mu","raw_affiliation_strings":["Department of Cardiology of The First Affiliated Hospital, Xinjiang Medical University Urumqi 830000, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology of The First Affiliated Hospital, Xinjiang Medical University Urumqi 830000, Xinjiang, China","institution_ids":["https://openalex.org/I154093214","https://openalex.org/I2802734952"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039107335","display_name":"Yuemei Hou","orcid":"https://orcid.org/0000-0002-1616-6537","observed_orcids":["https://orcid.org/0000-0002-1616-6537"]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]},{"id":"https://openalex.org/I2802734952","display_name":"First Affiliated Hospital of Xinjiang Medical University","ror":"https://ror.org/02qx1ae98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802734952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue-Mei Hou","raw_affiliation_strings":["Department of Cardiology of The First Affiliated Hospital, Xinjiang Medical University Urumqi 830000, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology of The First Affiliated Hospital, Xinjiang Medical University Urumqi 830000, Xinjiang, China","institution_ids":["https://openalex.org/I154093214","https://openalex.org/I2802734952"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2306,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.49080574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"8","issue":"2","first_page":"2506","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kv1-3","display_name":"Kv1.3 potassium channel","score":0.9710000157356262},{"id":"https://openalex.org/keywords/voltage-gated-potassium-channels","display_name":"voltage-gated potassium channels","score":0.9210000038146973},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.9589999914169312},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.9190000295639038},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8199999928474426},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9599999785423279},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.9169999957084656}],"concepts":[{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.8091933727264404},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.640155553817749},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.6387778520584106},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5906922817230225},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.5833009481430054},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5551109313964844},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4782342314720154},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.4731674790382385},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.46451157331466675},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.4610340893268585},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.41262632608413696},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28575098514556885},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.18822693824768066},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15608957409858704},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07282125949859619},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmid:25932196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25932196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4402843","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4402843/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},{"id":"mag:2188305878","doi":null,"is_oa":false,"landing_page_url":"https://www.ijcem.com/files/ijcem0004382.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2461743510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25932196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4402843","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4402843/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W177784532","https://openalex.org/W1578151714","https://openalex.org/W1841074395","https://openalex.org/W1973834397","https://openalex.org/W1985948706","https://openalex.org/W1987052041","https://openalex.org/W1993173834","https://openalex.org/W2001454343","https://openalex.org/W2010227433","https://openalex.org/W2022765352","https://openalex.org/W2023547574","https://openalex.org/W2028944098","https://openalex.org/W2030660601","https://openalex.org/W2039707738","https://openalex.org/W2047877170","https://openalex.org/W2049865778","https://openalex.org/W2052531952","https://openalex.org/W2056038215","https://openalex.org/W2065521882","https://openalex.org/W2076722320","https://openalex.org/W2082555858","https://openalex.org/W2108442939","https://openalex.org/W2117242701","https://openalex.org/W2121633161","https://openalex.org/W2123659751","https://openalex.org/W2132194740","https://openalex.org/W2136342591","https://openalex.org/W2137608879","https://openalex.org/W2371765312","https://openalex.org/W2415455910","https://openalex.org/W2470712224","https://openalex.org/W3035918500"],"related_works":["https://openalex.org/W2461743510","https://openalex.org/W2390388348","https://openalex.org/W2371765312","https://openalex.org/W2356552394","https://openalex.org/W2980699389","https://openalex.org/W2368910702","https://openalex.org/W2470712224","https://openalex.org/W1968249144","https://openalex.org/W4243734386","https://openalex.org/W2353756589"],"abstract_inverted_index":{"AIMS:":[0],"Our":[1],"previous":[2],"studies":[3],"showed":[4],"that":[5,213],"expression":[6,46,84,168],"and":[7,47,66,82,90,123,186,201],"functional":[8,48],"profile":[9,49],"of":[10,19,38,50,62,95,99,126,137,147,174,179,183,226],"voltage-dependent":[11],"potassium":[12,175],"channels":[13,101,176,192],"Kv1.3":[14,34,51,127,191,214],"were":[15,85,128,193],"increased":[16,55,130],"in":[17,35,58,93,102,114,131,135,152,177,195,199],"lymphocytes":[18,94,103,178],"spontaneously":[20],"hypertensive":[21],"rats":[22],"(SHR)":[23],"compared":[24],"to":[25,54],"normotensive":[26],"rats,":[27],"suggesting":[28],"a":[29,220],"crucial":[30],"role":[31],"for":[32,223],"lymphocyte":[33,136],"the":[36,45,79,144,224],"development":[37,225],"hypertension.":[39],"Here,":[40],"we":[41],"further":[42],"investigated":[43],"whether":[44],"was":[52,73,104,112,149],"related":[53],"blood":[56,71,110,163,205],"pressure":[57,72,76,111,164,206],"SHR":[59,138,180,200],"with":[60,167,203],"age":[61,182],"4,":[63],"8,":[64,184],"16":[65,185],"24":[67,187],"wk.":[68,188],"METHODS:":[69],"Systolic":[70,109],"measured":[74,105],"through":[75],"device":[77],"around":[78],"tail.":[80],"mRNA":[81,122],"protein":[83,124],"assessed":[86],"by":[87,106],"real-time":[88],"PCR":[89],"western":[91],"blot":[92],"SHR.":[96],"Current":[97],"density":[98,146,173],"Kv":[100,148],"patch-clamp.":[107],"RESULTS:":[108],"elevated":[113],"an":[115,132,153,196],"age-dependent":[116,133,154,197],"manner":[117,134,155,198],"(ANOVA":[118,139,156],"P":[119,140,157],"<":[120,141,158],"0.05).":[121,142,159],"level":[125],"significantly":[129],"Moreover,":[143],"current":[145,172],"dramatically":[150],"enhanced":[151],"CONCLUSION:":[160],"The":[161,209],"systolic":[162,204],"positively":[165],"correlated":[166],"as":[169,171,219],"well":[170],"at":[181],"In":[189],"conclusion,":[190],"upregulated":[194],"correlates":[202],"during":[207,228],"aging.":[208,229],"present":[210],"study":[211],"implies":[212],"blockers":[215],"may":[216],"be":[217],"applied":[218],"therapeutic":[221],"treatment":[222],"hypertension":[227]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}