{"id":"https://openalex.org/W2188274179","doi":null,"title":"Role of reactive oxygen species in p53 activation during cisplatin-induced apoptosis of rat mesangial cells.","display_name":"Role of reactive oxygen species in p53 activation during cisplatin-induced apoptosis of rat mesangial cells.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2188274179","mag":"2188274179","pmid":"https://pubmed.ncbi.nlm.nih.gov/24817286"},"language":"en","primary_location":{"id":"pmid:24817286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24817286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101141992","display_name":"Ju Sm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I77079311","display_name":"Wonkwang University","ror":"https://ror.org/006776986","country_code":"KR","type":"education","lineage":["https://openalex.org/I77079311"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"S-M Ju","raw_affiliation_strings":["Department of Pathology, College of Korean Medicine, Wonkwang University, Iksan, Jeonbuk, Republic of Korea. omdjbh@wku.ac.kr","Department of Pathology, College of Korean Medicine, Wonkwang University , Iksan, Jeonbuk , Republic of Korea "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, College of Korean Medicine, Wonkwang University, Iksan, Jeonbuk, Republic of Korea. omdjbh@wku.ac.kr","institution_ids":["https://openalex.org/I77079311"]},{"raw_affiliation_string":"Department of Pathology, College of Korean Medicine, Wonkwang University , Iksan, Jeonbuk , Republic of Korea ","institution_ids":["https://openalex.org/I77079311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007964323","display_name":"Pae Ho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H-O Pae","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089797580","display_name":"Kim Ws","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W-S Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"D-G Kang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D-G Kang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105470705","display_name":"Lee Hs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H-S Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005487205","display_name":"Jeon Bh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B-H Jeon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2372,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.91373761,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"8","first_page":"1135","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9580000042915344},{"id":"https://openalex.org/keywords/p53-activation","display_name":"p53 activation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/mesangial-cells","display_name":"mesangial cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cisplatin-induced-nephrotoxicity","display_name":"cisplatin nephrotoxicity","score":0.9509999752044678},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9129999876022339},{"id":"https://openalex.org/keywords/parp-cleavage","display_name":"PARP cleavage","score":0.8859999775886536},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.8180000185966492},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.871999979019165},{"id":"https://openalex.org/keywords/dimethylthiourea","display_name":"dimethylthiourea","score":0.9110000133514404},{"id":"https://openalex.org/keywords/p53-phosphorylation","display_name":"p53 phosphorylation","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.8683861494064331},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.809412956237793},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.763850212097168},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7100180387496948},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.6579776406288147},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.6110953092575073},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.4716101288795471},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4666350483894348},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.43357717990875244},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.43022894859313965},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.41278278827667236},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40174877643585205},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35366755723953247},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32744041085243225},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2547377347946167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17750319838523865},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.13025689125061035},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.07992136478424072},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06720384955406189},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.048717200756073},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050527","descriptor_name":"Mesangial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050527","descriptor_name":"Mesangial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050527","descriptor_name":"Mesangial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24817286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24817286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},{"id":"mag:2188274179","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24817286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W38682668","https://openalex.org/W91109734","https://openalex.org/W169793338","https://openalex.org/W1967234838","https://openalex.org/W1983965827","https://openalex.org/W1997716192","https://openalex.org/W1999605572","https://openalex.org/W2000697304","https://openalex.org/W2011033166","https://openalex.org/W2013881430","https://openalex.org/W2037473273","https://openalex.org/W2056386224","https://openalex.org/W2059247778","https://openalex.org/W2063303943","https://openalex.org/W2070150128","https://openalex.org/W2070692423","https://openalex.org/W2087664337","https://openalex.org/W2091766574","https://openalex.org/W2108075715","https://openalex.org/W2127618819","https://openalex.org/W2141037581"],"related_works":["https://openalex.org/W2059247778","https://openalex.org/W2065415498","https://openalex.org/W1822254038","https://openalex.org/W3213838895","https://openalex.org/W1965769177","https://openalex.org/W2103379588","https://openalex.org/W2067265129","https://openalex.org/W2038876417","https://openalex.org/W1995041486","https://openalex.org/W2102027021"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,71],"OBJECTIVES:":[2],"Nephrotoxicity":[3],"is":[4,47],"one":[5,17],"of":[6,11,18,42,84,111,119,194,199,213],"the":[7,12,40,80,192,209,217],"main":[8,20],"side":[9],"effects":[10],"anticancer":[13],"drug":[14],"cisplatin,":[15],"and":[16,109,121,129,143,146,151,162,172,177],"its":[19],"therapeutic":[21,211],"limitations.":[22],"It":[23],"has":[24],"been":[25],"suggested":[26],"that":[27,191],"p53":[28,43,64,122,149,155,179,205],"activation":[29,44,65,142,150,180],"plays":[30],"important":[31],"roles":[32],"in":[33,66,79,181,215],"renal":[34,182],"cell":[35,138],"injury":[36],"by":[37,45,58,96,106,126],"cisplatin.":[38,186],"However,":[39],"mechanism":[41],"cisplatin":[46,59,78,195,218],"unclear.":[48],"This":[49],"study":[50],"examined":[51],"whether":[52],"reactive":[53],"oxygen":[54],"species":[55],"(ROS)":[56],"production":[57,176],"would":[60],"be":[61],"linked":[62],"to":[63,185,196],"rat":[67,200],"mesangial":[68,201],"cells.":[69],"MATERIALS":[70],"METHODS:":[72],"Renal":[73],"cells":[74,183,202],"were":[75,124],"incubated":[76],"with":[77],"absence":[81],"or":[82,89],"presence":[83],"pifithrin-a":[85],"(PFT),":[86],"N-acetyl-cysteine":[87],"(NAC),":[88],"dimethylthiourea":[90],"(DMT).":[91],"Cell":[92],"viability":[93],"was":[94,104],"evaluated":[95,105],"3-(4,5-dimethyl-2-thiazol":[97],"yl)-2,5-diphenyl":[98],"tetrazolium":[99],"bromide":[100],"(MTT)":[101],"assay.":[102],"Apoptosis":[103],"caspase-3":[107,141],"activity":[108],"cleavage":[110],"poly":[112],"(ADP-ribose)":[113],"polymerase":[114],"(PARP).":[115],"The":[116,154],"relative":[117],"levels":[118],"ROS":[120,152,175],"phosphorylation":[123],"determined":[125],"fluorometric":[127],"assay":[128],"Western":[130],"blot":[131],"analysis,":[132],"respectively.":[133],"RESULTS:":[134],"Cisplatin":[135],"induced":[136],"apoptotic":[137],"death":[139],"via":[140],"PARP":[144],"cleavage,":[145],"also":[147,166],"increased":[148],"production.":[153],"inhibitor":[156],"PFT":[157],"inhibited":[158,167],"cisplatin-induced":[159,168],"apoptosis.":[160,169],"NAC":[161,171],"DMT,":[163],"two":[164],"antioxidants,":[165],"Interestingly,":[170],"DMT":[173],"reduced":[174],"suppressed":[178],"exposed":[184],"CONCLUSIONS:":[187],"Our":[188],"results":[189],"suggest":[190],"ability":[193],"induce":[197],"apoptosis":[198],"requires":[203],"ROS-dependent":[204],"activation,":[206],"thus,":[207],"supporting":[208],"potential":[210],"role":[212],"antioxidants":[214],"preventing":[216],"nephrotoxicity.":[219]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}