{"id":"https://openalex.org/W2188226124","doi":null,"title":"Novel agents for the treatment of pancreatic adenocarcinoma: any light at the end of the tunnel? Highlights from the \"2010 ASCO Annual Meeting\". Chicago, IL, USA. June 4-8, 2010.","display_name":"Novel agents for the treatment of pancreatic adenocarcinoma: any light at the end of the tunnel? Highlights from the \"2010 ASCO Annual Meeting\". Chicago, IL, USA. June 4-8, 2010.","publication_year":2010,"publication_date":"2010-07-05","ids":{"openalex":"https://openalex.org/W2188226124","mag":"2188226124","pmid":"https://pubmed.ncbi.nlm.nih.gov/20601803"},"language":"en","primary_location":{"id":"pmid:20601803","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20601803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOP : Journal of the pancreas","raw_type":"Evaluation Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073550585","display_name":"Anastasios Dimou","orcid":"https://orcid.org/0000-0002-3950-3305","observed_orcids":["https://orcid.org/0000-0002-3950-3305"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anastasios T Dimou","raw_affiliation_strings":["Department of Pathology, Yale University School of Medicine, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106524954","display_name":"Konstantinos Nikolaos Syrigos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Konstantinos N Syrigos","raw_affiliation_strings":["Oncology Unit, Third Department of Medicine, Athens Medical School. Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Unit, Third Department of Medicine, Athens Medical School. Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110323346","display_name":"M. W. Saif","orcid":"https://orcid.org/0000-0001-8154-957X","observed_orcids":["https://orcid.org/0000-0001-8154-957X","https://orcid.org/0000-0003-0599-4991"]},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muhammad Wasif Saif","raw_affiliation_strings":["Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale University School of Medicine. New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale University School of Medicine. New Haven, CT, USA","institution_ids":["https://openalex.org/I2802730090","https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3244,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.61786062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"11","issue":"4","first_page":"324","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/novel-anticancer-agents","display_name":"novel anticancer agents","score":0.8460000157356262},{"id":"https://openalex.org/keywords/igf1r-inhibition","display_name":"IGF1R inhibition","score":0.9829999804496765},{"id":"https://openalex.org/keywords/ixabepilone","display_name":"ixabepilone","score":0.9950000047683716},{"id":"https://openalex.org/keywords/microtubule-stabilization","display_name":"microtubule stabilization","score":0.8949999809265137},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.75},{"id":"https://openalex.org/keywords/nab-paclitaxel","display_name":"nab-paclitaxel","score":0.9919999837875366},{"id":"https://openalex.org/keywords/angiogenesis-inhibitors","display_name":"angiogenesis inhibitors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ctla-4-blockade","display_name":"CTLA-4 blockade","score":0.9940000176429749},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.46799999475479126},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6909999847412109},{"id":"https://openalex.org/keywords/clinical-trial-results","display_name":"clinical trial results","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8213215470314026},{"id":"https://openalex.org/C2779194965","wikidata":"https://www.wikidata.org/wiki/Q11711607","display_name":"Ixabepilone","level":5,"score":0.7806195616722107},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.7692817449569702},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5720148086547852},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5415527820587158},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.4991264343261719},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4951576292514801},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3657143712043762},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.18395423889160156},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.1480695903301239}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002641","descriptor_name":"Chicago","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003226","descriptor_name":"Congresses as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008495","descriptor_name":"Medical Oncology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008495","descriptor_name":"Medical Oncology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012955","descriptor_name":"Societies, Medical","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20601803","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20601803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOP : Journal of the pancreas","raw_type":"Evaluation Study"},{"id":"mag:2188226124","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20601803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W2097995306","https://openalex.org/W2101995865","https://openalex.org/W2115898240","https://openalex.org/W2158170204","https://openalex.org/W2246814730","https://openalex.org/W2269253534","https://openalex.org/W2335859318","https://openalex.org/W2495871154","https://openalex.org/W2524964077","https://openalex.org/W3134530972"],"related_works":["https://openalex.org/W6977659972","https://openalex.org/W2095818182","https://openalex.org/W6959000844","https://openalex.org/W7100650661","https://openalex.org/W1517741478","https://openalex.org/W7095649046","https://openalex.org/W1904711260","https://openalex.org/W2607280346","https://openalex.org/W2106629178","https://openalex.org/W1856880182"],"abstract_inverted_index":{"Pancreatic":[0],"cancer":[1,24],"is":[2,18,88,151],"a":[3,29,89,107],"disease":[4],"with":[5,67,71,85],"dismal":[6],"prognosis":[7,80],"and":[8,57,135,144],"treatment":[9],"options":[10],"are":[11],"limited.":[12],"Development":[13],"of":[14,22,43,140],"novel":[15,30],"active":[16],"compounds":[17],"mandatory.":[19],"A":[20],"number":[21],"pancreatic":[23],"clinical":[25,110,149],"trials":[26,150],"that":[27,51,94],"included":[28],"agent":[31],"among":[32],"their":[33],"arms":[34],"were":[35],"presented":[36],"at":[37],"the":[38,141,148],"recent":[39],"2010":[40],"American":[41],"Society":[42],"Clinical":[44],"Oncology":[45],"(ASCO)":[46],"Annual":[47],"Meeting.":[48],"It":[49],"appears":[50],"IGF-1R":[52],"inhibition":[53],"might":[54,102],"be":[55,60,103,128],"effective":[56],"this":[58],"should":[59],"tested":[61,93],"in":[62,69,79,83,106,132],"further":[63],"trials.":[64,137],"Microtubule":[65],"stabilization":[66],"ixabepilone":[68],"combination":[70,84,90,101],"EGFR":[72],"does":[73],"not":[74,91,114],"lead":[75],"to":[76,127],"promising":[77],"improvement":[78],"whereas":[81],"nab-paclitaxel":[82],"anti-angiogenetic":[86],"agents":[87],"previously":[92],"showed":[95],"an":[96,119],"acceptable":[97,120],"safety":[98],"profile.":[99],"This":[100],"worth":[104],"testing":[105],"phase":[108,133],"II":[109,134],"trial.":[111],"Last":[112],"but":[113,123],"least,":[115],"CTLA-4":[116],"blockade":[117],"has":[118],"toxicity":[121],"profile":[122],"its":[124],"efficacy":[125],"needs":[126],"proven":[129],"over":[130],"placebo":[131],"III":[136],"Finally,":[138],"understanding":[139],"tumor":[142],"biology":[143],"biomarker":[145],"analysis":[146],"from":[147],"warranted.":[152]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
