{"id":"https://openalex.org/W2188169093","doi":null,"title":"Curcumin-altered p53-response genes regulate radiosensitivity in p53-mutant Ewing's sarcoma cells.","display_name":"Curcumin-altered p53-response genes regulate radiosensitivity in p53-mutant Ewing's sarcoma cells.","publication_year":2010,"publication_date":"2010-10-01","ids":{"openalex":"https://openalex.org/W2188169093","mag":"2188169093","pmid":"https://pubmed.ncbi.nlm.nih.gov/21036715"},"language":"en","primary_location":{"id":"pmid:21036715","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21036715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069398684","display_name":"Jamunarani Veeraraghavan","orcid":"https://orcid.org/0000-0002-9524-9487","observed_orcids":["https://orcid.org/0000-0002-9524-9487"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]},{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Veeraraghavan","raw_affiliation_strings":["Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA","University of Oklahoma,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"University of Oklahoma,","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101583041","display_name":"Mohan Natarajan","orcid":"https://orcid.org/0000-0001-5652-9681","observed_orcids":["https://orcid.org/0000-0001-5652-9681"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Natarajan","raw_affiliation_strings":["Otolaryngology, Head & Neck Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otolaryngology, Head & Neck Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086040458","display_name":"Terence S. Herman","orcid":"https://orcid.org/0000-0001-8647-4124","observed_orcids":["https://orcid.org/0000-0001-8647-4124"]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T S Herman","raw_affiliation_strings":["University of Oklahoma,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oklahoma,","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018397996","display_name":"Natarajan Aravindan","orcid":"https://orcid.org/0000-0001-9150-3911","observed_orcids":["https://orcid.org/0000-0001-9150-3911"]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Aravindan","raw_affiliation_strings":["University of Oklahoma,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oklahoma,","institution_ids":["https://openalex.org/I8692664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.178,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.71589085,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"30","issue":"10","first_page":"4007","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.10220000147819519,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":1.0},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9760000109672546},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9929999709129333},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9240000247955322},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7649999856948853},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/clonal-expansion","display_name":"clonal expansion","score":0.8930000066757202},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.9323513507843018},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.8114766478538513},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7174491882324219},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.656670093536377},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5863659977912903},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.57228022813797},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5487086772918701},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5439188480377197},{"id":"https://openalex.org/C2777586341","wikidata":"https://www.wikidata.org/wiki/Q1138580","display_name":"Ewing's sarcoma","level":3,"score":0.5271862745285034},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.43593835830688477},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.43213313817977905},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25560253858566284},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24657180905342102},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.2128523290157318},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20374605059623718},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17302757501602173},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.16866323351860046},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12347835302352905},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10291382670402527}],"mesh":[{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007259","descriptor_name":"Infrared Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012512","descriptor_name":"Sarcoma, Ewing","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012512","descriptor_name":"Sarcoma, Ewing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012512","descriptor_name":"Sarcoma, Ewing","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:21036715","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21036715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2188169093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21036715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W74993898","https://openalex.org/W239065484","https://openalex.org/W1767560565","https://openalex.org/W1930102516","https://openalex.org/W1969385456","https://openalex.org/W1975213794","https://openalex.org/W1979833262","https://openalex.org/W1983603161","https://openalex.org/W1990779081","https://openalex.org/W2001106708","https://openalex.org/W2018652620","https://openalex.org/W2025836954","https://openalex.org/W2033629987","https://openalex.org/W2035522858","https://openalex.org/W2038173255","https://openalex.org/W2038259382","https://openalex.org/W2049820006","https://openalex.org/W2060055090","https://openalex.org/W2065889429","https://openalex.org/W2067011460","https://openalex.org/W2068004114","https://openalex.org/W2070237373","https://openalex.org/W2070878775","https://openalex.org/W2074720507","https://openalex.org/W2082588078","https://openalex.org/W2087600880","https://openalex.org/W2089218510","https://openalex.org/W2100251566","https://openalex.org/W2111866285","https://openalex.org/W2113598181","https://openalex.org/W2128472785","https://openalex.org/W2135295352","https://openalex.org/W2139981029","https://openalex.org/W2149768039","https://openalex.org/W2159879659","https://openalex.org/W2161233858","https://openalex.org/W2167639932","https://openalex.org/W2169238639","https://openalex.org/W2187456576","https://openalex.org/W2190434739","https://openalex.org/W2224993107","https://openalex.org/W2602961860"],"related_works":["https://openalex.org/W2038259382","https://openalex.org/W3028784257","https://openalex.org/W2322244096","https://openalex.org/W2949134605","https://openalex.org/W7064813976","https://openalex.org/W2136740551","https://openalex.org/W2336899573","https://openalex.org/W2057903885","https://openalex.org/W1409137253","https://openalex.org/W4378695698"],"abstract_inverted_index":{"AIM:":[0],"Curcumin":[1,69],"has":[2],"been":[3],"demonstrated":[4],"to":[5,38,92,149],"have":[6],"antitumor":[7],"effects":[8],"including":[9,16],"radiosensitization":[10],"by":[11,135],"modulating":[12],"many":[13],"molecular":[14],"targets":[15,54,147],"p53.":[17],"Herein,":[18],"we":[19],"investigated":[20],"the":[21,93,141],"radiosensitizing":[22],"effect":[23],"of":[24,51,75,100,145],"curcumin":[25,43,109,117,129],"in":[26,58],"p53":[27,52,101],"mutant":[28],"Ewing's":[29],"sarcoma":[30],"(ES)":[31],"cells.":[32],"MATERIALS":[33],"AND":[34],"METHODS:":[35],"Cells":[36],"exposed":[37],"radiation":[39,72,105],"with":[40,83],"or":[41],"without":[42],"were":[44],"examined":[45],"for":[46],"transcriptional":[47,96],"and":[48,55,65,77,79,97,113,121],"translational":[49,98],"levels":[50,99],"downstream":[53,146],"its":[56],"influence":[57],"regulated":[59],"apoptosis,":[60],"DNA":[61,114],"fragmentation,":[62],"cell":[63],"survival":[64],"clonal":[66,122],"expansion.":[67,123],"RESULTS:":[68],"significantly":[70],"caused":[71,110],"induced":[73],"expression":[74],"p21":[76],"Bax,":[78],"reduced":[80],"BclXl,":[81],"Mcl1":[82],"only":[84],"marginal":[85],"Bcl2":[86],"modulation.":[87],"As":[88],"a":[89],"positive":[90],"control":[91],"study,":[94],"both":[95],"remained":[102],"unchanged":[103],"after":[104],"with/without":[106],"curcumin.":[107],"Conversely,":[108],"radiation-induced":[111,119],"apoptosis":[112],"fragmentation.":[115],"Consistently,":[116],"enhanced":[118],"cytotoxicity":[120],"CONCLUSION:":[124],"These":[125],"results":[126],"suggest":[127],"that":[128],"potentially":[130],"radiosensitizes":[131],"p53-mutant":[132],"ES":[133],"cells":[134],"regulating":[136],"IR-modulated":[137],"p53-response":[138],"genes.":[139],"However,":[140],"curcumin-associated":[142],"p53-independent":[143],"regulation":[144],"remains":[148],"be":[150],"explored.":[151]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}