{"id":"https://openalex.org/W2188163797","doi":null,"title":"The Candida albicans AAA ATPase homologue of Saccharomyces cerevisiae Rix7p (YLL034c) is essential for proper morphology, biofilm formation and activity of secreted aspartyl proteinases.","display_name":"The Candida albicans AAA ATPase homologue of Saccharomyces cerevisiae Rix7p (YLL034c) is essential for proper morphology, biofilm formation and activity of secreted aspartyl proteinases.","publication_year":2006,"publication_date":"2006-11-30","ids":{"openalex":"https://openalex.org/W2188163797","mag":"2188163797","pmid":"https://pubmed.ncbi.nlm.nih.gov/17183478"},"language":"en","primary_location":{"id":"pmid:17183478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17183478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics and molecular research : GMR","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://repositorio.unifesp.br/11600/43716","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044776932","display_name":"Analy Salles de Azevedo Melo","orcid":"https://orcid.org/0000-0001-6900-6468","observed_orcids":["https://orcid.org/0000-0001-6900-6468"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"A S A Melo","raw_affiliation_strings":["Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil","Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051033506","display_name":"Ana Carolina Barbosa Padovan","orcid":"https://orcid.org/0000-0001-6731-3835","observed_orcids":["https://orcid.org/0000-0001-6731-3835"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A C B Padovan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028893763","display_name":"R. C. Serafim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R C Serafim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006664742","display_name":"Luciano Puzer","orcid":"https://orcid.org/0000-0002-4412-0974","observed_orcids":["https://orcid.org/0000-0002-4412-0974"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Puzer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078684766","display_name":"Adriana K. Carmona","orcid":"https://orcid.org/0000-0003-3311-5456","observed_orcids":["https://orcid.org/0000-0003-3311-5456"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A K Carmona","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057185934","display_name":"Luiz Juliano","orcid":"https://orcid.org/0000-0002-5589-2822","observed_orcids":["https://orcid.org/0000-0002-5589-2822"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Juliano Neto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064731500","display_name":"Adriana Brunstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Brunstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004247456","display_name":"Marcelo R. S. Briones","orcid":"https://orcid.org/0000-0001-8045-2477","observed_orcids":["https://orcid.org/0000-0001-8045-2477","https://orcid.org/0000-0001-5734-7601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M R S Briones","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2245,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.44801693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":"4","first_page":"664","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.06960000097751617,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9980000257492065},{"id":"https://openalex.org/keywords/aaa-proteins","display_name":"AAA+ ATPase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hyphal-morphogenesis","display_name":"hyphal morphogenesis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/yeast-to-hypha-transition","display_name":"yeast-to-hypha transition","score":0.7870000004768372},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/secreted-aspartyl-proteinases","display_name":"secreted aspartyl proteinases","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ribosome-biogenesis","display_name":"ribosome biogenesis","score":0.6830000281333923},{"id":"https://openalex.org/keywords/vacuoles","display_name":"vacuoles","score":0.6579999923706055},{"id":"https://openalex.org/keywords/nuclear-localization-signal","display_name":"nuclear localization signal","score":0.8180000185966492},{"id":"https://openalex.org/keywords/antifungal-drug-targets","display_name":"antifungal drug targets","score":0.8349999785423279},{"id":"https://openalex.org/keywords/pathogenicity","display_name":"pathogenicity","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.7588310241699219},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7272140979766846},{"id":"https://openalex.org/C90080823","wikidata":"https://www.wikidata.org/wiki/Q193129","display_name":"Hypha","level":2,"score":0.7190408110618591},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.5912923216819763},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5621645450592041},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5557001233100891},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.555633008480072},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.5025155544281006},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.44932278990745544},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4433349370956421},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38993462920188904},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3720204830169678},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2193753719329834},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1865755319595337},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.11057740449905396}],"mesh":[{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025301","descriptor_name":"Hyphae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D025301","descriptor_name":"Hyphae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025301","descriptor_name":"Hyphae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"pmid:17183478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17183478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics and molecular research : GMR","raw_type":"Journal Article"},{"id":"pmh:oai:americanae.aecid.es:3195503","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/11600/43716","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNIFESP","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:repositorio.unifesp.br:11600/43716","doi":null,"is_oa":true,"landing_page_url":"http://www.funpecrp.com.br/gmr/year2006/vol4-5/gmr0256_abstract.htm","pdf_url":"http://www.funpecrp.com.br/gmr/year2006/vol4-5/gmr0256_abstract.htm","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.85.3049","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.85.3049","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.funpecrp.com.br/gmr/year2006/vol4-5/pdf/gmr0256.pdf","raw_type":"text"},{"id":"mag:2188163797","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17183478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3195503","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/11600/43716","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNIFESP","raw_type":"info:eu-repo/semantics/publishedVersion"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2188163797.pdf","grobid_xml":"https://content.openalex.org/works/W2188163797.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W63281979","https://openalex.org/W155914900","https://openalex.org/W1487958751","https://openalex.org/W1517190867","https://openalex.org/W1527254461","https://openalex.org/W1550420614","https://openalex.org/W1561565107","https://openalex.org/W1670638886","https://openalex.org/W1892030338","https://openalex.org/W1910229370","https://openalex.org/W1970770879","https://openalex.org/W1971159078","https://openalex.org/W1972078523","https://openalex.org/W1988725811","https://openalex.org/W1992693662","https://openalex.org/W1999340863","https://openalex.org/W2002024202","https://openalex.org/W2005836438","https://openalex.org/W2008893410","https://openalex.org/W2010335504","https://openalex.org/W2011758386","https://openalex.org/W2017519756","https://openalex.org/W2028904598","https://openalex.org/W2030091988","https://openalex.org/W2030983566","https://openalex.org/W2037257931","https://openalex.org/W2040551057","https://openalex.org/W2042161296","https://openalex.org/W2058216045","https://openalex.org/W2067459366","https://openalex.org/W2069241820","https://openalex.org/W2074138863","https://openalex.org/W2079196169","https://openalex.org/W2081370923","https://openalex.org/W2084021973","https://openalex.org/W2095906727","https://openalex.org/W2098370509","https://openalex.org/W2099992860","https://openalex.org/W2102621484","https://openalex.org/W2104389433","https://openalex.org/W2104642445","https://openalex.org/W2106258670","https://openalex.org/W2106451562","https://openalex.org/W2111777764","https://openalex.org/W2124790653","https://openalex.org/W2125605543","https://openalex.org/W2126975650","https://openalex.org/W2140935709","https://openalex.org/W2144634347","https://openalex.org/W2146126849","https://openalex.org/W2148698017","https://openalex.org/W2149160071","https://openalex.org/W2153207137","https://openalex.org/W2161444534","https://openalex.org/W2162891889","https://openalex.org/W2163811015","https://openalex.org/W2164075646","https://openalex.org/W2164291163","https://openalex.org/W2169043974","https://openalex.org/W2171690440","https://openalex.org/W2344388889","https://openalex.org/W3217097258","https://openalex.org/W7098838276","https://openalex.org/W7099585975"],"related_works":["https://openalex.org/W2030091988","https://openalex.org/W7097085954","https://openalex.org/W2162566576","https://openalex.org/W7098128453","https://openalex.org/W1974989710","https://openalex.org/W2305873498","https://openalex.org/W2125605543","https://openalex.org/W2383370945","https://openalex.org/W2154445113","https://openalex.org/W7098950806"],"abstract_inverted_index":{"Proper":[0],"morphology":[1,148],"is":[2,141,157],"essential":[3,55],"for":[4,56,111,159,179],"the":[5,73,77,134,145,168],"ability":[6],"of":[7,52,67,70,116,137,161,170],"Candida":[8],"albicans":[9,30],"to":[10,48,143],"switch":[11],"between":[12],"yeast":[13,57],"and":[14,16,59,97,124,149,152],"hyphae":[15],"thereby":[17],"sustain":[18],"its":[19],"virulence.":[20],"Here":[21],"we":[22,165],"identified,":[23],"by":[24,72],"differential":[25],"screening,":[26],"a":[27,49,61,90,113,176],"novel":[28,177],"C.":[29],"AAA":[31,53],"ATPase":[32],"encoding":[33],"gene,":[34],"CaYLL34":[35,46,171],"(RIX7),":[36],"with":[37],"enhanced":[38],"expression":[39],"in":[40,100,109],"hyphae.":[41],"Phylogenetic":[42],"analysis":[43],"suggests":[44],"that":[45,133,154,167],"belongs":[47],"\"VCP-like\"":[50],"subgroup":[51],"ATPases":[54],"viability":[58],"contains":[60],"bipartite":[62],"nuclear":[63],"localization":[64],"signal.":[65],"Inactivation":[66],"one":[68],"copy":[69],"CaYLL34,":[71],"URA-Blaster":[74],"method,":[75],"generated":[76],"heterozygous":[78],"mutant":[79],"strain":[80,83],"M61.":[81],"This":[82],"has":[84],"severe":[85],"phenotypic":[86],"alterations,":[87],"such":[88],"as":[89,175],"highly":[91],"increased":[92],"vacuole,":[93],"abnormal":[94],"cell":[95],"shape":[96],"reduced":[98],"growth":[99],"different":[101],"conditions.":[102],"Also,":[103],"major":[104],"pathogenicity":[105,150],"factors":[106,151],"are":[107],"affected":[108],"M61,":[110],"instance,":[112],"significant":[114],"decrease":[115],"hypha":[117],"formation":[118],"(>90%),":[119],"surface":[120],"biofilm":[121],"adhesion":[122],"(86%)":[123],"secreted":[125],"aspartyl":[126],"proteinase":[127],"activity":[128],"(76.5%).":[129],"Our":[130],"results":[131],"show":[132],"partial":[135],"impairment":[136],"CaYll34p":[138],"cellular":[139,147],"levels":[140],"sufficient":[142],"affect":[144],"proper":[146],"suggest":[153],"this":[155],"protein":[156],"required":[158],"biogenesis":[160],"ribosomal":[162],"subunits.":[163],"Accordingly,":[164],"propose":[166],"product":[169],"could":[172],"be":[173],"tested":[174],"target":[178],"antifungal":[180],"drugs.":[181]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}