{"id":"https://openalex.org/W2188104697","doi":null,"title":"The role of estrogen and estrogen receptorbeta in choroidal neovascularization.","display_name":"The role of estrogen and estrogen receptorbeta in choroidal neovascularization.","publication_year":2004,"publication_date":"2004-12-06","ids":{"openalex":"https://openalex.org/W2188104697","mag":"2188104697","pmid":"https://pubmed.ncbi.nlm.nih.gov/15616479"},"language":"en","primary_location":{"id":"pmid:15616479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15616479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004472237","display_name":"Mai Tanemura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mai Tanemura","raw_affiliation_strings":["Department of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160554937","display_name":"Noriko Miyamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Noriko Miyamoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160473245","display_name":"Michiko Mandai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michiko Mandai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037819174","display_name":"Hiroshi Kamizuru","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Kamizuru","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021225431","display_name":"Sotaro Ooto","orcid":"https://orcid.org/0000-0002-4609-8416","observed_orcids":["https://orcid.org/0000-0002-4609-8416"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sotaro Ooto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086910361","display_name":"Tsutomu Yasukawa","orcid":"https://orcid.org/0000-0001-9913-1905","observed_orcids":["https://orcid.org/0000-0001-9913-1905"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsutomu Yasukawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030655388","display_name":"Masayo Takahashi","orcid":"https://orcid.org/0000-0003-1836-6484","observed_orcids":["https://orcid.org/0000-0003-1836-6484"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masayo Takahashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5160566500","display_name":"Yoshihito Honda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshihito Honda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.021,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.76166847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"10","issue":null,"first_page":"923","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/choroidal-neovascularization","display_name":"choroidal neovascularization","score":1.0},{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":0.8889999985694885},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.953000009059906},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.9369999766349792},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8659999966621399},{"id":"https://openalex.org/keywords/laser-photocoagulation","display_name":"laser photocoagulation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.9679999947547913},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6610000133514404},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6140000224113464},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2781359195","wikidata":"https://www.wikidata.org/wiki/Q5105209","display_name":"Choroidal neovascularization","level":3,"score":0.7235918045043945},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.7115865349769592},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6628165245056152},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3657130300998688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3582223951816559},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34822899103164673},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.14383062720298767},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.13374072313308716},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.13164246082305908},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.09492066502571106}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010052","descriptor_name":"Ovariectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011914","descriptor_name":"Rats, Inbred BN","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017075","descriptor_name":"Laser Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047629","descriptor_name":"Estrogen Receptor beta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:15616479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15616479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"mag:2188104697","doi":null,"is_oa":false,"landing_page_url":"http://molvis.org/molvis/v10/a111/v10a111-tanemura.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2416917442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15616479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W146222765","https://openalex.org/W333949626","https://openalex.org/W1480510623","https://openalex.org/W1489281785","https://openalex.org/W1518478504","https://openalex.org/W1540765995","https://openalex.org/W1543801259","https://openalex.org/W1579034041","https://openalex.org/W1659749843","https://openalex.org/W1964068703","https://openalex.org/W1967004211","https://openalex.org/W1969764844","https://openalex.org/W1981427921","https://openalex.org/W1981612052","https://openalex.org/W1995404023","https://openalex.org/W1998525239","https://openalex.org/W1999414884","https://openalex.org/W2007917457","https://openalex.org/W2014584008","https://openalex.org/W2022252536","https://openalex.org/W2034035365","https://openalex.org/W2046445641","https://openalex.org/W2046598230","https://openalex.org/W2048728589","https://openalex.org/W2051109788","https://openalex.org/W2060025135","https://openalex.org/W2064482843","https://openalex.org/W2073883348","https://openalex.org/W2074429500","https://openalex.org/W2078662987","https://openalex.org/W2079743814","https://openalex.org/W2080657339","https://openalex.org/W2081727392","https://openalex.org/W2084506573","https://openalex.org/W2093802575","https://openalex.org/W2108749205","https://openalex.org/W2112590471","https://openalex.org/W2126533417","https://openalex.org/W2134812217","https://openalex.org/W2139258437","https://openalex.org/W2139874845","https://openalex.org/W2141791604","https://openalex.org/W2152723385","https://openalex.org/W2164887773"],"related_works":["https://openalex.org/W7097029971","https://openalex.org/W2416917442","https://openalex.org/W1133156682","https://openalex.org/W878871872","https://openalex.org/W3082609859","https://openalex.org/W3211687336","https://openalex.org/W1988485999","https://openalex.org/W3194077775","https://openalex.org/W2737697534","https://openalex.org/W7011652052"],"abstract_inverted_index":{"PURPOSE:":[0],"Choroidal":[1],"neovascularization":[2,25],"(CNV)":[3],"under":[4],"the":[5,45,95],"age":[6],"of":[7,20,63,75,111,127],"50":[8],"is":[9],"more":[10,163],"often":[11],"observed":[12],"in":[13,16,30,44,55,101,118,133,144,147,164,167,205,217,227],"women":[14],"than":[15,146,166],"men.":[17],"The":[18,61,109,125],"effects":[19],"17beta-estradiol":[21],"(E2)":[22],"on":[23,169,179],"choroidal":[24],"development":[26,65,235],"were":[27,84,98,113,135,141,161,197],"investigated":[28],"both":[29],"animal":[31],"models":[32],"and":[33,58,68,80,94,105,131,150,157,178,193,202,214,222],"cultured":[34],"cells":[35,123],"to":[36,175,185],"see":[37],"if":[38],"estrogen":[39,128],"receptors":[40],"(ERs)":[41],"are":[42,224],"involved":[43],"process.":[46],"METHODS:":[47],"CNV":[48,64,92,134,139,228,234],"was":[49,66],"induced":[50],"by":[51,115,200,236],"fundus":[52],"laser":[53],"photocoagulation":[54,83,154,201],"adult":[56],"male":[57],"female":[59],"rats.":[60],"degree":[62],"scored":[67],"compared":[69,85,174,184],"between":[70,86],"them.":[71],"Gene":[72],"expression":[73,213,240],"levels":[74,160],"VEGF":[76],"receptor":[77],"2":[78],"(VEGFR2)":[79],"ERs":[81,112],"after":[82,153,188],"genders":[87],"using":[88],"real":[89],"time":[90],"PCR.":[91],"formation":[93],"gene":[96,159,195,212,239],"expressions":[97,196],"also":[99],"examined":[100],"ovariectomized":[102,206],"females":[103,145,165],"with":[104],"without":[106],"E2":[107,203,208],"treatment.":[108],"roles":[110],"studied":[114,136],"overexpressing":[116,219],"them":[117],"human":[119],"umbilical":[120],"vein":[121],"endothelial":[122],"(HUVECs).":[124],"localization":[126],"receptorbeta":[129],"(ERbeta)":[130],"VEGFR2":[132,156,194,211,223,238],"immunohistochemically.":[137],"RESULTS:":[138],"scores":[140],"significantly":[142,209],"higher":[143],"males":[148,168],"14":[149],"21":[151],"days":[152],"(<0.05).":[155],"ERbeta":[158,192,221],"increased":[162],"day":[170,180],"7":[171],"(3.4":[172],"fold":[173,183],"1.8":[176],"fold)":[177,187],"3":[181],"(5.8":[182],"2.3":[186],"photocoagulation,":[189],"respectively.":[190],"Both":[191],"additively":[198],"enhanced":[199,210],"treatment":[204],"females.":[207],"cell":[215],"proliferation":[216],"HUVECs":[218],"ERbeta.":[220,242],"well":[225],"co-localized":[226],"tissue.":[229],"CONCLUSIONS:":[230],"Estrogen":[231],"may":[232],"promote":[233],"increasing":[237],"via":[241]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
