{"id":"https://openalex.org/W2188043344","doi":null,"title":"Stability of MALAT-1, a nuclear long non-coding RNA in mammalian cells, varies in various cancer cells.","display_name":"Stability of MALAT-1, a nuclear long non-coding RNA in mammalian cells, varies in various cancer cells.","publication_year":2010,"publication_date":"2010-08-01","ids":{"openalex":"https://openalex.org/W2188043344","mag":"2188043344","pmid":"https://pubmed.ncbi.nlm.nih.gov/22491206"},"language":"en","primary_location":{"id":"pmid:22491206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22491206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug discoveries & therapeutics","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027187360","display_name":"Hidenori Tani","orcid":"https://orcid.org/0000-0001-6390-4136","observed_orcids":["https://orcid.org/0000-0001-6390-4136"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Tani","raw_affiliation_strings":["Radioisotope Center, The University of Tokyo, Tokyo, Japan","Radioisotope Center, The Univ. of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radioisotope Center, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Radioisotope Center, The Univ. of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070921279","display_name":"Yo Nakamura","orcid":"https://orcid.org/0000-0002-1156-9732","observed_orcids":["https://orcid.org/0000-0002-1156-9732"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Nakamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025554856","display_name":"Kenichi Ijiri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Ijiri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5016202171","display_name":"Nobuyoshi Akimitsu","orcid":"https://orcid.org/0000-0002-3190-2942","observed_orcids":["https://orcid.org/0000-0002-3190-2942"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Akimitsu","raw_affiliation_strings":["Univ.\\ of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ.\\ of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4875,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.63511753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"4","issue":"4","first_page":"235","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0892999991774559,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malat1","display_name":"MALAT1","score":1.0},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9190000295639038},{"id":"https://openalex.org/keywords/rna-stability","display_name":"RNA stability","score":0.6779999732971191},{"id":"https://openalex.org/keywords/half-life","display_name":"half-life","score":0.7269999980926514},{"id":"https://openalex.org/keywords/nuclear-speckles","display_name":"nuclear speckles","score":0.9070000052452087},{"id":"https://openalex.org/keywords/xrn2","display_name":"XRN2","score":0.871999979019165},{"id":"https://openalex.org/keywords/parn","display_name":"PARN","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mtr4","display_name":"Mtr4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/rna-helicase","display_name":"RNA helicase","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cancer-cells","display_name":"cancer cells","score":0.6779999732971191},{"id":"https://openalex.org/keywords/mrna-degradation","display_name":"mRNA degradation","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.628294050693512},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6070670485496521},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.5564148426055908},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.48654642701148987},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4706004559993744},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.46881937980651855},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.46202099323272705},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45726120471954346},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.45566290616989136},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.45087501406669617},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4447934329509735},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40403085947036743},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2586606740951538}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020871","descriptor_name":"RNA Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:22491206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22491206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug discoveries & therapeutics","raw_type":"Journal Article"},{"id":"mag:2188043344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22491206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1879996757","https://openalex.org/W1988309554","https://openalex.org/W1989967763","https://openalex.org/W1991634050","https://openalex.org/W1992605446","https://openalex.org/W2003260938","https://openalex.org/W2005636452","https://openalex.org/W2006254819","https://openalex.org/W2007015770","https://openalex.org/W2024039709","https://openalex.org/W2029706883","https://openalex.org/W2032501207","https://openalex.org/W2051282896","https://openalex.org/W2059968749","https://openalex.org/W2075559286","https://openalex.org/W2091204895","https://openalex.org/W2107685513","https://openalex.org/W2112387241","https://openalex.org/W2128619556","https://openalex.org/W2131428840","https://openalex.org/W2134812217","https://openalex.org/W2160649230","https://openalex.org/W7100804310"],"related_works":["https://openalex.org/W7204174587","https://openalex.org/W2052308608","https://openalex.org/W1956510785","https://openalex.org/W2068728873","https://openalex.org/W2913809822","https://openalex.org/W2806353550","https://openalex.org/W3177460801","https://openalex.org/W4385555591","https://openalex.org/W3033791775","https://openalex.org/W2774855547"],"abstract_inverted_index":{"Recent":[0],"large-scale":[1],"transcriptome":[2],"analyses":[3],"have":[4,98,115,165],"revealed":[5,22],"a":[6,128,155],"large":[7],"number":[8],"of":[9,32,43,51,63,69,74,118,157,170,205],"transcripts":[10,65],"with":[11],"low":[12],"protein-coding":[13],"potential,":[14],"known":[15,105,191],"as":[16,154],"non-coding":[17,76],"RNAs":[18],"(ncRNAs).":[19],"Many":[20],"studies":[21],"that":[23,134,167],"several":[24],"long":[25,75,110,129,159],"ncRNAs":[26],"are":[27],"involved":[28,93],"in":[29,39,46,54,79,94,108,137,148,151,161,181],"the":[30,40,47,55,61,67,80,149,168,211],"regulation":[31,50,73],"genome":[33],"organization":[34],"and":[35,66,141,189],"gene":[36],"expression,":[37,71],"or":[38,194,202],"structural":[41],"components":[42,207],"functional":[44],"domains":[45],"nucleus.":[48],"As":[49],"mRNA":[52,96],"decay":[53,78,97,117,213],"cytoplasm":[56],"is":[57,82,104,127,135],"crucial":[58],"for":[59,87],"controlling":[60],"abundance":[62],"cellular":[64],"levels":[68],"protein":[70],"so":[72],"RNA":[77,195],"nucleus":[81,150],"considered":[83],"to":[84,144,177],"be":[85,145],"important":[86],"biological":[88],"function.":[89],"Although":[90],"enzymatic":[91],"pathways":[92],"cytoplasmic":[95],"been":[99],"studied":[100],"extensively,":[101],"far":[102],"less":[103],"about":[106],"those":[107],"nuclear":[109,152,158,192],"ncRNA":[111,133,160],"decay.":[112],"Here,":[113],"we":[114],"investigated":[116],"metastasis":[119],"associated":[120],"lung":[121],"adenocarcinoma":[122],"transcript":[123],"1":[124],"(MALAT-1),":[125],"which":[126],"(~":[130],"8":[131],"kb)":[132],"misregulated":[136],"many":[138],"human":[139],"cancers":[140],"was":[142],"shown":[143],"retained":[146],"specifically":[147],"speckles,":[153],"model":[156],"mammalian":[162],"cells.":[163,184],"We":[164],"found":[166],"half-life":[169],"MALAT-1":[171,200,212],"ranges":[172],"from":[173],"~":[174],"9":[175],"h":[176,180],">":[178],"12":[179],"various":[182],"cancer":[183],"Moreover,":[185],"Xrn2,":[186],"PM/Scl-75,":[187],"PARN,":[188],"Mtr4,":[190],"RNases":[193],"helicases,":[196],"did":[197,208],"not":[198,209],"affect":[199],"degradation":[201],"single":[203],"knockdown":[204],"these":[206],"change":[210],"rate.":[214]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
