{"id":"https://openalex.org/W2188010225","doi":"https://doi.org/10.1158/1535-7163.1551.3.12","title":"Different proteome pattern of epidermal growth factor receptor\u2013positive colorectal cancer cell lines that are responsive and nonresponsive to C225 antibody treatment","display_name":"Different proteome pattern of epidermal growth factor receptor\u2013positive colorectal cancer cell lines that are responsive and nonresponsive to C225 antibody treatment","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W2188010225","doi":"https://doi.org/10.1158/1535-7163.1551.3.12","mag":"2188010225","pmid":"https://pubmed.ncbi.nlm.nih.gov/15634648"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.1551.3.12","doi":"https://doi.org/10.1158/1535-7163.1551.3.12","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.1551.3.12","pdf_url":"https://aacrjournals.org/mct/article-pdf/3/12/1551/1867391/1551-1558.pdf","source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/mct/article-pdf/3/12/1551/1867391/1551-1558.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020048515","display_name":"Sergej Skvortsov","orcid":"https://orcid.org/0000-0002-5989-573X","observed_orcids":["https://orcid.org/0000-0002-5989-573X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sergej Skvortsov","raw_affiliation_strings":["1Internal Medicine, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Internal Medicine, Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021352781","display_name":"Bettina Sarg","orcid":"https://orcid.org/0000-0002-4785-8739","observed_orcids":["https://orcid.org/0000-0002-4785-8739"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Bettina Sarg","raw_affiliation_strings":["4Institute of Medical Chemistry and Biochemistry, Innsbruck Medical University, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Institute of Medical Chemistry and Biochemistry, Innsbruck Medical University, Innsbruck, Austria","institution_ids":["https://openalex.org/I143397708"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Judith Loeffler-Ragg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Judith Loeffler-Ragg","raw_affiliation_strings":["1Internal Medicine, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Internal Medicine, Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037883383","display_name":"Ira Skvortsova","orcid":"https://orcid.org/0000-0001-8993-611X","observed_orcids":["https://orcid.org/0000-0001-8993-611X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ira Skvortsova","raw_affiliation_strings":["2Radiotherapy-Radiooncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Radiotherapy-Radiooncology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110661843","display_name":"Herbert H. Lindner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Herbert Lindner","raw_affiliation_strings":["4Institute of Medical Chemistry and Biochemistry, Innsbruck Medical University, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Institute of Medical Chemistry and Biochemistry, Innsbruck Medical University, Innsbruck, Austria","institution_ids":["https://openalex.org/I143397708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110827224","display_name":"Helmut Werner Ott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helmut Werner Ott","raw_affiliation_strings":["3Gynaecology and Obstetrics and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Gynaecology and Obstetrics and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108396167","display_name":"Peter H. Lukas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Lukas","raw_affiliation_strings":["2Radiotherapy-Radiooncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Radiotherapy-Radiooncology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048120516","display_name":"Karl Illmensee","orcid":"https://orcid.org/0000-0001-5780-1528","observed_orcids":["https://orcid.org/0000-0001-5780-1528"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karl Illmensee","raw_affiliation_strings":["3Gynaecology and Obstetrics and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Gynaecology and Obstetrics and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019658294","display_name":"Heinz Zwierzina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heinz Zwierzina","raw_affiliation_strings":["1Internal Medicine, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Internal Medicine, Departments of","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3893,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.88371148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"3","issue":"12","first_page":"1551","last_page":"1558"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.02810000069439411,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.9369999766349792},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9210000038146973},{"id":"https://openalex.org/keywords/anti-egfr-monoclonal-antibody","display_name":"anti-EGFR monoclonal antibody","score":0.9049999713897705},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.6470000147819519},{"id":"https://openalex.org/keywords/proteomic-profiling","display_name":"proteomic profiling","score":0.8799999952316284},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.7020000219345093},{"id":"https://openalex.org/keywords/egfr-signaling","display_name":"EGFR signaling","score":0.6639999747276306},{"id":"https://openalex.org/keywords/glutathione-s-transferase-pi","display_name":"glutathione S-transferase pi","score":0.9890000224113464},{"id":"https://openalex.org/keywords/fatty-acid-binding-protein","display_name":"fatty acid binding protein","score":0.984000027179718},{"id":"https://openalex.org/keywords/hsp27","display_name":"HSP27","score":1.0},{"id":"https://openalex.org/keywords/anti-apoptotic-proteins","display_name":"anti-apoptotic proteins","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.690483033657074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5310490727424622},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5090817809104919},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.4934171736240387},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.49262291193008423},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4712662696838379},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4397142231464386},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4114657938480377},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4036860167980194},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3242429494857788},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3205520510673523},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2910318374633789},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2525399327278137},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16134333610534668},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07950925827026367}],"mesh":[{"descriptor_ui":"D000068818","descriptor_name":"Cetuximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1158/1535-7163.1551.3.12","doi":"https://doi.org/10.1158/1535-7163.1551.3.12","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.1551.3.12","pdf_url":"https://aacrjournals.org/mct/article-pdf/3/12/1551/1867391/1551-1558.pdf","source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},{"id":"pmid:15634648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15634648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer therapeutics","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.896.6628","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.896.6628","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mct.aacrjournals.org/content/3/12/1551.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.1551.3.12","doi":"https://doi.org/10.1158/1535-7163.1551.3.12","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.1551.3.12","pdf_url":"https://aacrjournals.org/mct/article-pdf/3/12/1551/1867391/1551-1558.pdf","source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322325","display_name":"Oesterreichische Nationalbank","ror":"https://ror.org/00nkcmy90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2188010225.pdf","grobid_xml":"https://content.openalex.org/works/W2188010225.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W57491703","https://openalex.org/W117475386","https://openalex.org/W1490790087","https://openalex.org/W1558285980","https://openalex.org/W1571730618","https://openalex.org/W1646723094","https://openalex.org/W1796205058","https://openalex.org/W1914299239","https://openalex.org/W1945415917","https://openalex.org/W1973557583","https://openalex.org/W1976559908","https://openalex.org/W1976690731","https://openalex.org/W1992183189","https://openalex.org/W1997016102","https://openalex.org/W2012987137","https://openalex.org/W2023296859","https://openalex.org/W2023660230","https://openalex.org/W2027230571","https://openalex.org/W2028350610","https://openalex.org/W2035204919","https://openalex.org/W2035722698","https://openalex.org/W2036822121","https://openalex.org/W2038882649","https://openalex.org/W2045491811","https://openalex.org/W2051982497","https://openalex.org/W2068931555","https://openalex.org/W2081273196","https://openalex.org/W2085864574","https://openalex.org/W2085894544","https://openalex.org/W2104316189","https://openalex.org/W2123206362","https://openalex.org/W2124133870","https://openalex.org/W2138011982","https://openalex.org/W2150079073","https://openalex.org/W2150081412","https://openalex.org/W2150115597","https://openalex.org/W2153398089","https://openalex.org/W2153534791","https://openalex.org/W2154208670","https://openalex.org/W2155199761","https://openalex.org/W2155977433","https://openalex.org/W2159506251","https://openalex.org/W2163402367","https://openalex.org/W2169731354","https://openalex.org/W2170517479","https://openalex.org/W2419547593"],"related_works":["https://openalex.org/W7095405883","https://openalex.org/W2042520293","https://openalex.org/W2059999122","https://openalex.org/W6904298955","https://openalex.org/W2041063937","https://openalex.org/W2106764013","https://openalex.org/W2331737450","https://openalex.org/W4385857908","https://openalex.org/W2090875414","https://openalex.org/W2892031110"],"abstract_inverted_index":{"The":[0],"monoclonal":[1,216],"antibody":[2],"C225":[3,194],"directed":[4],"against":[5],"the":[6,29,55,158,165,189,203],"epidermal":[7],"growth":[8,47,100],"factor":[9],"receptor":[10],"(EGFR)":[11],"blocks":[12],"downstream":[13],"mitogenic":[14],"signaling":[15,210],"and":[16,33,49,81,109,130,146,177,211],"is":[17],"effective":[18],"in":[19,45,119,127,208],"patients":[20],"with":[21,64,77,92,157],"advanced":[22],"colorectal":[23,60],"cancer.":[24],"Clinical":[25],"data,":[26],"however,":[27],"suggest":[28],"presence":[30],"of":[31,58,68,86,98,101,134,161,169,191],"primary":[32],"secondary":[34],"resistance":[35,51],"mechanisms":[36],"that":[37],"are":[38,125],"hardly":[39],"understood.":[40],"To":[41],"define":[42],"proteins":[43,116,124,170],"involved":[44,126,207],"EGFR-triggered":[46],"regulation":[48],"potential":[50],"mechanisms,":[52],"we":[53,113],"characterized":[54],"proteome":[56],"profile":[57],"two":[59],"cancer":[61],"cell":[62,121],"lines":[63],"a":[65,72,83],"high":[66],"expression":[67,168],"functional":[69],"EGFR":[70,87,209],"but":[71],"different":[73],"response":[74],"to":[75,155,188,193],"treatment":[76],"C225.":[78],"In":[79],"Caco-2":[80,95],"HRT-18,":[82],"complete":[84],"saturation":[85],"was":[88,103],"achieved":[89],"after":[90],"incubation":[91],"C225;":[93],"whereas":[94],"showed":[96],"inhibition":[97],"proliferation,":[99],"HRT-18":[102,192],"not":[104,153],"suppressed.":[105],"Using":[106],"two-dimensional":[107],"electrophoresis":[108],"subsequent":[110],"mass":[111],"spectrometry,":[112],"identified":[114],"14":[115],"differentially":[117],"expressed":[118],"both":[120],"lines.":[122],"All":[123],"metabolic":[128],"pathways":[129],"malignant":[131],"growth.":[132],"Expression":[133],"enzymes":[135],"such":[136,171],"as":[137,172],"ubiquitin":[138],"carboxyl-terminal":[139],"hydrolase":[140],"isozyme":[141],"1,":[142],"glutathione":[143],"S-transferase":[144],"P,":[145],"chloride":[147],"intracellular":[148],"channel":[149],"protein":[150,176,180,205],"1":[151],"does":[152],"seem":[154],"interfere":[156],"antiproliferative":[159],"effect":[160],"anti-EGFR":[162],"antibody.":[163],"On":[164],"other":[166],"hand,":[167],"fatty":[173],"acid":[174],"binding":[175],"heat":[178],"shock":[179],"27":[181],"might":[182],"constitute":[183],"strong":[184],"antiapoptotic":[185],"effects":[186],"contributing":[187],"nonresponse":[190],"treatment.":[195],"Proteome-based":[196],"investigations":[197],"can":[198],"help":[199],"us":[200],"better":[201],"understand":[202],"complex":[204],"interactions":[206],"its":[212],"blockage":[213],"by":[214],"therapeutic":[215],"antibodies.":[217]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
