{"id":"https://openalex.org/W2187983259","doi":null,"title":"Quantitative measurement of regional cerebral blood flow using N-isopropyl-(iodine-123)p-iodoamphetamine and single-photon emission computed tomography.","display_name":"Quantitative measurement of regional cerebral blood flow using N-isopropyl-(iodine-123)p-iodoamphetamine and single-photon emission computed tomography.","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W2187983259","mag":"2187983259","pmid":"https://pubmed.ncbi.nlm.nih.gov/1403139"},"language":"en","primary_location":{"id":"pmid:1403139","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1403139","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014141740","display_name":"Gen Takeshita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"G Takeshita","raw_affiliation_strings":["Department of Radiology, Fujita Health University School of Medicine, Aichi, Japan","Department of Radiology, Fujita Health University School of Medicine, Aichi, Japan#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Fujita Health University School of Medicine, Aichi, Japan","institution_ids":["https://openalex.org/I145673806"]},{"raw_affiliation_string":"Department of Radiology, Fujita Health University School of Medicine, Aichi, Japan#TAB#","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083314404","display_name":"Hisato Maeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Maeda","raw_affiliation_strings":["Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021828197","display_name":"Kaori Nakane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Nakane","raw_affiliation_strings":["Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049773772","display_name":"Hiroshi Toyama","orcid":"https://orcid.org/0000-0002-5341-1693","observed_orcids":["https://orcid.org/0000-0002-5341-1693"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Toyama","raw_affiliation_strings":["\u653e\u5c04\u7dda\u533b\u5b66"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u653e\u5c04\u7dda\u533b\u5b66","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018807388","display_name":"Eiji Sakakibara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"E Sakakibara","raw_affiliation_strings":["Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022090070","display_name":"Satoshi Komai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Komai","raw_affiliation_strings":["Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106402900","display_name":"Akira Takeuchi","orcid":"https://orcid.org/0009-0006-4263-0918","observed_orcids":["https://orcid.org/0009-0006-4263-0918"]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A Takeuchi","raw_affiliation_strings":["Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110144485","display_name":"Sukehiko Koga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Koga","raw_affiliation_strings":["Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Ono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Ono","raw_affiliation_strings":["Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072196799","display_name":"Tsuyoshi Nakagawa","orcid":"https://orcid.org/0000-0003-1967-0445","observed_orcids":["https://orcid.org/0000-0003-1967-0445"]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Nakagawa","raw_affiliation_strings":["Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2825,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.87945926,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":"33","issue":"10","first_page":"1741","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regional-cerebral-blood-flow","display_name":"regional cerebral blood flow","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dynamic-spect","display_name":"dynamic SPECT","score":0.7620000243186951},{"id":"https://openalex.org/keywords/time-activity-curves","display_name":"time-activity curves","score":0.777999997138977},{"id":"https://openalex.org/keywords/quantitative-spect","display_name":"quantitative SPECT","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C2779190346","wikidata":"https://www.wikidata.org/wiki/Q3801335","display_name":"Iodine-123","level":2,"score":0.9536330103874207},{"id":"https://openalex.org/C2780441642","wikidata":"https://www.wikidata.org/wiki/Q849737","display_name":"Single-photon emission computed tomography","level":2,"score":0.6689993739128113},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.6561622619628906},{"id":"https://openalex.org/C2778863792","wikidata":"https://www.wikidata.org/wiki/Q16909918","display_name":"TRACER","level":2,"score":0.6159572005271912},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.6111170053482056},{"id":"https://openalex.org/C2778064278","wikidata":"https://www.wikidata.org/wiki/Q5372630","display_name":"Emission computed tomography","level":3,"score":0.56777024269104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5052276253700256},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.49381765723228455},{"id":"https://openalex.org/C539932907","wikidata":"https://www.wikidata.org/wiki/Q1103","display_name":"Iodine","level":2,"score":0.47929778695106506},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.4603552222251892},{"id":"https://openalex.org/C23531484","wikidata":"https://www.wikidata.org/wiki/Q3196863","display_name":"Calibration curve","level":3,"score":0.44543176889419556},{"id":"https://openalex.org/C104264131","wikidata":"https://www.wikidata.org/wiki/Q898637","display_name":"Isopropyl","level":2,"score":0.43319451808929443},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.3719795048236847},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.3449695110321045},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.32195842266082764},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3101775050163269},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.2083728313446045},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17842504382133484},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.17259323596954346},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.09343519806861877},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08301416039466858},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000662","descriptor_name":"Amphetamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020367","descriptor_name":"Iofetamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1403139","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1403139","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"mag:2187983259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1403139","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1980196300","https://openalex.org/W1543308538","https://openalex.org/W214447509","https://openalex.org/W1838684139","https://openalex.org/W2412548637","https://openalex.org/W2069755531","https://openalex.org/W2418689936","https://openalex.org/W2413226580","https://openalex.org/W2396394219","https://openalex.org/W2321552585"],"abstract_inverted_index":{"We":[0],"have":[1],"developed":[2],"a":[3,35,157,180],"quantitative":[4],"method":[5,125],"of":[6,129,144,151],"measuring":[7],"regional":[8],"cerebral":[9],"blood":[10,53,82],"flow":[11],"(rCBF)":[12],"by":[13,75,80,120,162],"using":[14,34],"N-isopropyl-(iodine-123)p-iodoamphetamine":[15],"and":[16,39,73,100,169,179],"single-photon":[17],"emission":[18],"computed":[19],"tomography":[20],"(SPECT).":[21],"Twenty-five":[22],"dynamic":[23],"SPECT":[24,37,177],"images":[25],"(24":[26],"sec/scan)":[27],"were":[28,154],"collected":[29],"immediately":[30],"after":[31,86,108],"tracer":[32,87,109],"injection":[33,110],"ring-type":[36],"system":[38,178],"the":[40,51,66,76,103,121,127,130,164,170,176],"accumulation":[41],"curve":[42,48,55,62,69],"(C(t))":[43],"was":[44,56,63,95,118,138],"obtained.":[45],"The":[46,60,89,112],"time-activity":[47,68],"corresponding":[49],"to":[50,97],"arterial":[52],"activity":[54,78],"used":[57],"as":[58,102,126],"B(t).":[59,148],"latter":[61],"calculated":[64,119],"from":[65],"lung":[67],"monitored":[70],"during":[71,93],"scanning":[72,94],"corrected":[74],"actual":[77],"obtained":[79,155],"one-point":[81],"sampling":[83],"5":[84,106],"min":[85,107],"injection.":[88],"octanol":[90],"extraction":[91],"ratio":[92],"considered":[96],"be":[98],"constant":[99,114,166],"taken":[101],"value":[104],"measured":[105],"(E).":[111],"uptake":[113,165],"(K)":[115],"per":[116,167],"pixel":[117,168],"least":[122],"squares":[123],"fitting":[124],"slope":[128],"linear":[131],"relationship":[132],"in":[133],"which":[134],"C(t)/E":[135],"x":[136,142,147,159,186],"B(t)":[137],"plotted":[139],"against":[140],"E":[141],"integral":[143],"t(o)B(tau)d":[145],"tau/E":[146],"Functional":[149],"maps":[150],"rCBF":[152],"values":[153],"on":[156],"64":[158,160],"matrix":[161],"calculating":[163],"cross":[171],"calibration":[172],"factor":[173],"(CF)":[174],"between":[175],"well":[181],"counter":[182],"(rCBF":[183],"=":[184],"K.CF":[185],"100).":[187]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}