{"id":"https://openalex.org/W2187925992","doi":"https://doi.org/10.1517/14740338.2016.1128412","title":"Safety of oral tenofovir disoproxil fumarate-based pre-exposure prophylaxis for HIV prevention","display_name":"Safety of oral tenofovir disoproxil fumarate-based pre-exposure prophylaxis for HIV prevention","publication_year":2015,"publication_date":"2015-12-04","ids":{"openalex":"https://openalex.org/W2187925992","doi":"https://doi.org/10.1517/14740338.2016.1128412","mag":"2187925992","pmid":"https://pubmed.ncbi.nlm.nih.gov/26634852","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4755800"},"language":"en","primary_location":{"id":"doi:10.1517/14740338.2016.1128412","doi":"https://doi.org/10.1517/14740338.2016.1128412","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14740338.2016.1128412","pdf_url":null,"source":{"id":"https://openalex.org/S20709540","display_name":"Expert Opinion on Drug Safety","issn_l":"1474-0338","issn":["1474-0338","1744-764X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Safety","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4755800","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046791476","display_name":"Kenneth K. Mugwanya","orcid":"https://orcid.org/0000-0001-5208-7468","observed_orcids":["https://orcid.org/0000-0001-5208-7468"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I72227227","display_name":"Makerere University","ror":"https://ror.org/03dmz0111","country_code":"UG","type":"education","lineage":["https://openalex.org/I72227227"]}],"countries":["UG","US"],"is_corresponding":false,"raw_author_name":"Kenneth K. Mugwanya","raw_affiliation_strings":["Department of Epidemiology, University of Washington, Seattle, WA, USA","Department of Global Health, University of Washington, Seattle, WA, USA","Division of Disease Control, School of Public Health, Makerere University, Kampala, Uganda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Global Health, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Division of Disease Control, School of Public Health, Makerere University, Kampala, Uganda","institution_ids":["https://openalex.org/I72227227"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064486492","display_name":"Jared M. Baeten","orcid":"https://orcid.org/0000-0001-8242-8438","observed_orcids":["https://orcid.org/0000-0001-8242-8438"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jared M. Baeten","raw_affiliation_strings":["Department of Epidemiology, University of Washington, Seattle, WA, USA","Department of Global Health, University of Washington, Seattle, WA, USA","Department of Medicine, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Global Health, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064486492"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":0.6444,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.53535354,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"15","issue":"2","first_page":"265","last_page":"273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.7919999957084656,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.7919999957084656,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.20649999380111694,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tenofovir-disoproxil-fumarate","display_name":"tenofovir disoproxil fumarate","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hiv-pre-exposure-prophylaxis","display_name":"HIV pre-exposure prophylaxis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/hiv-prevention","display_name":"HIV prevention","score":0.734000027179718},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.9139999747276306},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.7870000004768372},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.9020000100135803},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.9779999852180481},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8140000104904175},{"id":"https://openalex.org/keywords/emtricitabine","display_name":"emtricitabine","score":0.9620000123977661},{"id":"https://openalex.org/keywords/sexual-and-reproductive-health","display_name":"sexual and reproductive health","score":0.9300000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9186954498291016},{"id":"https://openalex.org/C2779778239","wikidata":"https://www.wikidata.org/wiki/Q422604","display_name":"Emtricitabine","level":5,"score":0.8216444253921509},{"id":"https://openalex.org/C2779496540","wikidata":"https://www.wikidata.org/wiki/Q7239230","display_name":"Pre-exposure prophylaxis","level":5,"score":0.811894416809082},{"id":"https://openalex.org/C197746943","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Microbicide","level":3,"score":0.6607339978218079},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.5965146422386169},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5681523680686951},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4982447624206543},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.41814088821411133},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38426727056503296},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.32677602767944336},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19201713800430298},{"id":"https://openalex.org/C2776939746","wikidata":"https://www.wikidata.org/wiki/Q853451","display_name":"Men who have sex with men","level":4,"score":0.15620052814483643},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.13835453987121582},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.1081152856349945},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.10597458481788635},{"id":"https://openalex.org/C2776983459","wikidata":"https://www.wikidata.org/wiki/Q41083","display_name":"Syphilis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000068679","descriptor_name":"Emtricitabine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000068698","descriptor_name":"Tenofovir","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000068698","descriptor_name":"Tenofovir","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000068698","descriptor_name":"Tenofovir","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D065129","descriptor_name":"Pre-Exposure Prophylaxis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1517/14740338.2016.1128412","doi":"https://doi.org/10.1517/14740338.2016.1128412","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14740338.2016.1128412","pdf_url":null,"source":{"id":"https://openalex.org/S20709540","display_name":"Expert Opinion on Drug Safety","issn_l":"1474-0338","issn":["1474-0338","1744-764X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Safety","raw_type":"journal-article"},{"id":"pmid:26634852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26634852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on drug safety","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4144940","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4755800","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4755800","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4755800","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Expert Opin Drug Saf","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4144940","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4755800","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1084389469","display_name":"Delivery of integrated PrEP and ART for HIV prevention for couples in Kenya","funder_award_id":"R01MH095507","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6695913491","display_name":"University of Washington Foundation - to conduct a placebo-controlled proof-of-concept phase III trial of the safety and efficacy of TDF and FTC/TDF in reducing HIV acquisition among HI...","funder_award_id":"OPP47674","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"}],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1482153588","https://openalex.org/W1887045666","https://openalex.org/W1892068908","https://openalex.org/W1971662534","https://openalex.org/W1974380624","https://openalex.org/W1974877011","https://openalex.org/W1977072157","https://openalex.org/W1977229201","https://openalex.org/W1986694485","https://openalex.org/W1988338542","https://openalex.org/W1997346205","https://openalex.org/W2000761749","https://openalex.org/W2002570479","https://openalex.org/W2007666753","https://openalex.org/W2008815987","https://openalex.org/W2021803277","https://openalex.org/W2022226876","https://openalex.org/W2037565950","https://openalex.org/W2038662816","https://openalex.org/W2044369525","https://openalex.org/W2048943480","https://openalex.org/W2059286898","https://openalex.org/W2060132628","https://openalex.org/W2068674733","https://openalex.org/W2073986430","https://openalex.org/W2076431271","https://openalex.org/W2087258915","https://openalex.org/W2088232432","https://openalex.org/W2097057569","https://openalex.org/W2101619401","https://openalex.org/W2103920597","https://openalex.org/W2110530964","https://openalex.org/W2112632411","https://openalex.org/W2116531236","https://openalex.org/W2116605213","https://openalex.org/W2117057469","https://openalex.org/W2121296127","https://openalex.org/W2134966461","https://openalex.org/W2136985213","https://openalex.org/W2142748692","https://openalex.org/W2144095981","https://openalex.org/W2156094398","https://openalex.org/W2157921853","https://openalex.org/W2162226934","https://openalex.org/W2162761942","https://openalex.org/W2168251450","https://openalex.org/W2171609071","https://openalex.org/W2316970929","https://openalex.org/W2329960468","https://openalex.org/W2331361632","https://openalex.org/W3145257564","https://openalex.org/W4247593499"],"related_works":["https://openalex.org/W2898731012","https://openalex.org/W2399954151","https://openalex.org/W2462333574","https://openalex.org/W4283656038","https://openalex.org/W3040718826","https://openalex.org/W2780913653","https://openalex.org/W2048868585","https://openalex.org/W2181898081","https://openalex.org/W2766583960","https://openalex.org/W2890888425"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Tenofovir":[1],"disoproxil":[2],"fumarate":[3],"(TDF)-based":[4],"pre-exposure":[5,55,121],"prophylaxis":[6,56,122],"is":[7,36,80,123,133],"a":[8,46,83,124],"novel":[9],"HIV":[10,20,68,116,128,186],"prevention":[11,25],"strategy":[12],"for":[13,19,29,77,162,176],"individuals":[14],"at":[15,170],"increased":[16],"sexual":[17,70],"risk":[18,140,184],"infection.":[21,187],"For":[22],"any":[23],"biomedical":[24],"intervention,":[26],"the":[27,50,142,159,171,183],"bar":[28],"tolerating":[30],"adverse":[31],"effects":[32,61],"in":[33,102,148,182],"healthy":[34],"persons":[35],"high":[37],"compared":[38],"to":[39],"therapeutic":[40],"interventions.":[41],"AREAS":[42],"COVERED:":[43],"We":[44],"provide":[45],"concise":[47],"summary":[48],"of":[49,53,86,96,141,185],"clinical":[51],"safety":[52,95],"TDF-based":[54,97,120],"with":[57,104,166],"focus":[58],"on":[59,62],"TDF-related":[60],"tolerability,":[63],"kidney":[64],"function,":[65],"bone":[66,153],"density,":[67],"resistance,":[69],"and":[71,89,94,109,114,136,145,152,174],"reproductive":[72],"health.":[73],"The":[74,139],"evidence":[75],"base":[76],"this":[78],"review":[79],"derived":[81],"from":[82,107],"literature":[84],"search":[85],"both":[87],"randomized":[88],"observational":[90],"studies":[91],"evaluating":[92],"efficacy":[93],"PrEP,":[98],"TDF":[99],"alone":[100],"or":[101],"combination":[103],"emtricitabine,":[105],"identified":[106],"PUBMED":[108],"EMBASE":[110],"electronic":[111],"databases,":[112],"clinicaltrials.gov":[113],"major":[115],"conferences.":[117],"EXPERT":[118],"OPINION:":[119],"potent":[125],"intervention":[126],"against":[127],"acquisition":[129],"when":[130],"taken":[131],"which":[132],"generally":[134],"safe":[135],"well":[137,157],"tolerated.":[138],"small,":[143],"non-progressive,":[144],"reversible":[146],"decline":[147],"glomerular":[149],"filtration":[150],"rate":[151],"mineral":[154],"density":[155],"as":[156,158],"potential":[160],"selection":[161],"drug":[163],"resistance":[164],"associated":[165],"PrEP":[167],"are":[168],"outweighed,":[169],"population":[172],"level":[173],"broadly":[175],"individuals,":[177],"by":[178],"PrEP's":[179],"substantial":[180],"reduction":[181]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
