{"id":"https://openalex.org/W2187747015","doi":null,"title":"Radioimmunodetection of medullary thyroid carcinoma using indium-111 bivalent hapten and anti-CEA x anti-DTPA-indium bispecific antibody.","display_name":"Radioimmunodetection of medullary thyroid carcinoma using indium-111 bivalent hapten and anti-CEA x anti-DTPA-indium bispecific antibody.","publication_year":1998,"publication_date":"1998-07-01","ids":{"openalex":"https://openalex.org/W2187747015","mag":"2187747015","pmid":"https://pubmed.ncbi.nlm.nih.gov/9669389"},"language":"en","primary_location":{"id":"pmid:9669389","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9669389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004255429","display_name":"Jacques Barbet","orcid":"https://orcid.org/0000-0002-9188-984X","observed_orcids":["https://orcid.org/0000-0002-9188-984X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Barbet","raw_affiliation_strings":["Immunotech S.A., Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunotech S.A., Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111858185","display_name":"PATRICK PELTIER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Peltier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060771094","display_name":"St\u00e9phane Bardet","orcid":"https://orcid.org/0000-0002-1881-8674","observed_orcids":["https://orcid.org/0000-0002-1881-8674"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Bardet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113893455","display_name":"J.-P. Vuillez","orcid":"https://orcid.org/0000-0002-1344-7229","observed_orcids":["https://orcid.org/0000-0002-1344-7229"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J P Vuillez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016652365","display_name":"IVAN BACHELOT","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Bachelot","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020425357","display_name":"Sylvie Denet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Denet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108114669","display_name":"P. Olivier","orcid":"https://orcid.org/0000-0003-2841-7580","observed_orcids":["https://orcid.org/0000-0003-2841-7580"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Olivier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"F Leccia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Leccia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018183343","display_name":"B Corcuff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Corcuff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046226959","display_name":"Damien G. Huglo","orcid":"https://orcid.org/0000-0002-4986-9132","observed_orcids":["https://orcid.org/0000-0002-4986-9132"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Huglo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088780222","display_name":"Charles A. G. Proye","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Proye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059232135","display_name":"\u00c9ric Rouvier","orcid":"https://orcid.org/0000-0002-3541-900X","observed_orcids":["https://orcid.org/0000-0002-3541-900X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Rouvier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087129297","display_name":"P Meyer","orcid":"https://orcid.org/0000-0002-5793-4424","observed_orcids":["https://orcid.org/0000-0002-5793-4424"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Meyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111629101","display_name":"Jean\u2010Fran\u00e7ois Chatal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J F Chatal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.1712,"has_fulltext":false,"cited_by_count":102,"citation_normalized_percentile":{"value":0.93665446,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"39","issue":"7","first_page":"1172","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.6021000146865845,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.6021000146865845,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.388700008392334,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medullary-thyroid-carcinoma","display_name":"medullary thyroid carcinoma","score":1.0},{"id":"https://openalex.org/keywords/pretargeting","display_name":"pretargeting","score":0.6309999823570251},{"id":"https://openalex.org/keywords/radioimmunodetection","display_name":"radioimmunodetection","score":0.7519999742507935},{"id":"https://openalex.org/keywords/111in","display_name":"indium-111","score":0.9430000185966492},{"id":"https://openalex.org/keywords/bispecific-antibodies","display_name":"bispecific antibodies","score":0.9160000085830688},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.9070000052452087},{"id":"https://openalex.org/keywords/dtpa","display_name":"DTPA","score":0.8870000243186951},{"id":"https://openalex.org/keywords/immunoscintigraphy","display_name":"immunoscintigraphy","score":0.8989999890327454},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.8309999704360962},{"id":"https://openalex.org/keywords/thyroid-cancer-recurrence","display_name":"recurrent thyroid cancer","score":0.5960000157356262},{"id":"https://openalex.org/keywords/radioimmunoguided-surgery","display_name":"radioimmunoguided surgery","score":0.9490000009536743},{"id":"https://openalex.org/keywords/calcitonin","display_name":"calcitonin","score":0.8849999904632568},{"id":"https://openalex.org/keywords/tumor-recurrence-detection","display_name":"tumor recurrence detection","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C2777064799","wikidata":"https://www.wikidata.org/wiki/Q1660202","display_name":"Immunoscintigraphy","level":5,"score":0.957619845867157},{"id":"https://openalex.org/C2777836882","wikidata":"https://www.wikidata.org/wiki/Q22907915","display_name":"Pretargeting","level":5,"score":0.8828483819961548},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8076102137565613},{"id":"https://openalex.org/C2777387746","wikidata":"https://www.wikidata.org/wiki/Q769706","display_name":"Carcinoembryonic antigen","level":3,"score":0.568723201751709},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5242748260498047},{"id":"https://openalex.org/C2779627488","wikidata":"https://www.wikidata.org/wiki/Q315860","display_name":"Calcitonin","level":2,"score":0.5204023122787476},{"id":"https://openalex.org/C2779902710","wikidata":"https://www.wikidata.org/wiki/Q1130465","display_name":"Scintigraphy","level":2,"score":0.5164518356323242},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.43793922662734985},{"id":"https://openalex.org/C29144244","wikidata":"https://www.wikidata.org/wiki/Q506441","display_name":"Hapten","level":3,"score":0.41586390137672424},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.384299099445343},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3719100058078766},{"id":"https://openalex.org/C2776146153","wikidata":"https://www.wikidata.org/wiki/Q7281276","display_name":"Radioimmunotherapy","level":4,"score":0.3688742518424988},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.33512598276138306},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2731996774673462},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.19894254207611084},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.169464111328125},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10868331789970398}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002272","descriptor_name":"Carcinoembryonic Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004369","descriptor_name":"Pentetic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006241","descriptor_name":"Haptens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007205","descriptor_name":"Indium Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007430","descriptor_name":"Intraoperative Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016719","descriptor_name":"Radioimmunodetection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018276","descriptor_name":"Carcinoma, Medullary","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D018276","descriptor_name":"Carcinoma, Medullary","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D018276","descriptor_name":"Carcinoma, Medullary","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9669389","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9669389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Clinical Trial"},{"id":"mag:2187747015","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9669389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1952970584","https://openalex.org/W1965769405","https://openalex.org/W1981966209","https://openalex.org/W2016726024","https://openalex.org/W2020593256","https://openalex.org/W2067539812","https://openalex.org/W2094730403","https://openalex.org/W2120139412","https://openalex.org/W2132423819","https://openalex.org/W2150559364","https://openalex.org/W2321896809","https://openalex.org/W2336244231","https://openalex.org/W2414621545","https://openalex.org/W2417577641","https://openalex.org/W2418548227","https://openalex.org/W2437467043"],"related_works":["https://openalex.org/W2150559364","https://openalex.org/W2090791631","https://openalex.org/W2067539812","https://openalex.org/W2245344599","https://openalex.org/W2029476983","https://openalex.org/W189276170","https://openalex.org/W7097462749","https://openalex.org/W2400737786","https://openalex.org/W2038359528","https://openalex.org/W1565899755"],"abstract_inverted_index":{"UNLABELLED:":[0],"Pretargeting":[1],"labeled":[2],"bivalent":[3,95],"hapten":[4,97,125],"with":[5,107,164,177],"bispecific":[6,91],"antibodies":[7],"has":[8],"proven":[9],"feasible":[10],"in":[11,75,156,185,191,235,245,268],"the":[12,20,44,174,192,243,254,308],"clinic,":[13],"and":[14,30,50,58,63,93,121,204,281,289,303],"our":[15,68],"earlier":[16],"results":[17],"have":[18,218],"suggested":[19],"technique":[21,41,285],"may":[22,42],"be":[23,43],"very":[24],"sensitive":[25,64],"for":[26,291,301],"detecting":[27,292],"small":[28,293],"recurrences":[29,49],"metastases.":[31,166,298],"Medullary":[32],"thyroid":[33],"carcinoma":[34],"(MTC)":[35],"is":[36],"an":[37],"example":[38],"where":[39,251],"this":[40],"most":[45],"useful":[46],"since":[47],"local":[48],"isolated":[51],"metastases":[52,226],"are":[53],"removed":[54],"surgically":[55],"when":[56,128],"detected,":[57],"thyrocalcitonin":[59],"provides":[60],"a":[61,76,136,269],"specific":[62],"tumor":[65,149,169,294],"marker.":[66],"In":[67],"current":[69],"study,":[70],"we":[71],"evaluated":[72],"pretargeted":[73],"immunoscintigraphy":[74,180,302],"larger":[77],"number":[78],"of":[79,113,159,256,278,311],"MTC":[80],"patients.":[81,213,237],"METHODS:":[82],"Anti-carcinoembryonic":[83],"antigen":[84],"(CEA)":[85],"x":[86],"anti-diethylenetriaminepentaacetic":[87],"acid":[88],"(DTPA)":[89],"indium":[90],"antibody":[92],"111In-labeled":[94],"DTPA":[96],"were":[98,154,171,195,210,227],"administered":[99],"sequentially":[100],"(4-5":[101],"days":[102],"apart)":[103],"to":[104],"44":[105],"patients":[106,146,176,187,217,250],"elevated":[108],"circulating":[109,279],"calcitonin":[110,280],"after":[111,124],"resection":[112,255,266],"primary":[114],"MTC.":[115,313],"Immunoscintigraphy":[116],"was":[117,140,233,239],"performed":[118],"2,":[119],"5":[120,190,216],"24":[122],"hr":[123],"injection":[126],"and,":[127],"necessary,":[129],"at":[130],"longer":[131],"time":[132],"intervals.":[133],"When":[134],"available,":[135],"handheld":[137],"gamma":[138],"probe":[139],"used":[141,234],"during":[142],"surgery.":[143],"RESULTS:":[144],"Fifteen":[145],"had":[147],"known":[148],"sites":[150,170,184],"before":[151],"immunoscintigraphy.":[152],"Tumors":[153],"imaged":[155],"12":[157,246],"(80%)":[158],"these":[160],"patients,":[161,247],"including":[162,189,248,296],"3":[163],"liver":[165,225,297],"Five":[167],"unknown":[168],"detected.":[172],"For":[173],"29":[175],"occult":[178],"disease,":[179],"detected":[181,224],"high-activity":[182,228],"uptake":[183,229],"21":[186],"(72%),":[188],"liver.":[193],"Twelve":[194],"confirmed":[196],"by":[197,200,206,242],"surgery,":[198],"1":[199,205],"guided":[201,304],"morphologic":[202],"imaging":[203],"venous":[207],"catheterization.":[208],"There":[209],"2":[211],"false-positive":[212],"The":[214],"other":[215],"not":[219,258],"yet":[220],"been":[221],"confirmed.":[222],"All":[223],"areas.":[230],"Radioimmunoguided":[231],"surgery":[232,305],"14":[236],"It":[238],"considered":[240],"helpful":[241],"surgeon":[244],"4":[249],"it":[252],"determined":[253],"small,":[257],"palpable":[259],"nor":[260],"visible,":[261],"tumor-involved":[262],"lymph":[263],"nodes.":[264],"Surgical":[265],"resulted":[267],"significant":[270],"decrease":[271],"(8":[272],"patients)":[273],"or":[274],"normalization":[275],"(1":[276],"patient)":[277],"CEA.":[282],"CONCLUSION:":[283],"This":[284],"affords":[286],"high":[287],"sensitivity":[288],"specificity":[290],"lesions":[295],"Its":[299],"use":[300],"should":[306],"improve":[307],"therapeutic":[309],"management":[310],"recurrent":[312]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}