{"id":"https://openalex.org/W2187696908","doi":null,"title":"ASSOCIATION OF CYTOKINE GENE POLYMORPHISMS WITH ATOPIC DERMATITIS","display_name":"ASSOCIATION OF CYTOKINE GENE POLYMORPHISMS WITH ATOPIC DERMATITIS","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2187696908","mag":"2187696908"},"language":"en","primary_location":{"id":"mag:2187696908","doi":null,"is_oa":false,"landing_page_url":"http://tru.uni-sz.bg/tsj/vol8,Suppl.2,2010/Gaby%20Va6ina.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008031723","display_name":"G. Vashina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Vashina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025424380","display_name":"Lyuba Dineva Miteva","orcid":"https://orcid.org/0000-0002-0028-7692","observed_orcids":["https://orcid.org/0000-0002-0028-7692"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lyuba Miteva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0028-7692","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082247919","display_name":"E. Hristakieva","orcid":"https://orcid.org/0000-0003-0762-1072","observed_orcids":["https://orcid.org/0000-0003-0762-1072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Hristakieva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0762-1072","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5083392735","display_name":"Spaska Angelova Stanilova","orcid":"https://orcid.org/0000-0003-1368-9081","observed_orcids":["https://orcid.org/0000-0003-1368-9081"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u0421. \u0421\u0442\u0430\u043d\u0438\u043b\u043e\u0432\u0430","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1368-9081","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytokine-gene-polymorphisms","display_name":"cytokine gene polymorphisms","score":0.9290000200271606},{"id":"https://openalex.org/keywords/il12b","display_name":"IL12B","score":0.9200000166893005},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8579999804496765},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9779999852180481},{"id":"https://openalex.org/keywords/bulgarian-population","display_name":"Bulgarian population","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.7275229096412659},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6998987793922424},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6682623624801636},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6365993618965149},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5566980242729187},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.5565382242202759},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4637518525123596},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.4482010304927826},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.4297749996185303},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.412382036447525},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.385949045419693},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23335611820220947},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08236438035964966}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2187696908","doi":null,"is_oa":false,"landing_page_url":"http://tru.uni-sz.bg/tsj/vol8,Suppl.2,2010/Gaby%20Va6ina.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1585477246","https://openalex.org/W1971488413","https://openalex.org/W1971605070","https://openalex.org/W1979349547","https://openalex.org/W1985776841","https://openalex.org/W1990127128","https://openalex.org/W1992129727","https://openalex.org/W2012090562","https://openalex.org/W2026125421","https://openalex.org/W2028763115","https://openalex.org/W2031799130","https://openalex.org/W2034623767","https://openalex.org/W2041587494","https://openalex.org/W2047121064","https://openalex.org/W2073146016","https://openalex.org/W2078956320","https://openalex.org/W2087413669","https://openalex.org/W2105288072","https://openalex.org/W2110192356","https://openalex.org/W2118512649","https://openalex.org/W2143138262","https://openalex.org/W2247666211"],"related_works":["https://openalex.org/W7112225970","https://openalex.org/W2107491712","https://openalex.org/W3037285604","https://openalex.org/W2927675443","https://openalex.org/W2595572111","https://openalex.org/W2159394251","https://openalex.org/W2055409464","https://openalex.org/W2054507486","https://openalex.org/W2947053599","https://openalex.org/W1971488413"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,81],"present":[2,47,151],"study":[3,172],"examine":[4],"the":[5,20,46,51,67,112,116,132,157,161,175],"influence":[6],"of":[7,14,22,50,84,94,101,129,134],"IL12Bpro":[8,68,162],"polymorphism,":[9,89],"A/C":[10,53,90],"substitution":[11,18,91,98],"in":[12,19,45,55,73,92,99,111,142,179,191],"3\u2019UTR":[13,56,93],"IL12B":[15,52,95],"and":[16,39,65,70,96,126,138],"A/G":[17],"promoter":[21,100],"IL10":[23,74],"on":[24],"susceptibility":[25,139,190],"to":[26,108,140,185],"atopic":[27],"dermatitis":[28],"(AD)":[29],"among":[30,103],"Bulgarian":[31,144,193],"patients.":[32],"METHODS:":[33],"Fifty":[34],"three":[35,135],"patients":[36,105],"with":[37,167,188],"AD":[38,104,141,168,189],"206":[40],"healthy":[41],"controls":[42],"were":[43],"included":[44],"study.":[48],"Genotyping":[49],"polymorphism":[54,69,72,163],"was":[57,106,146,164],"performed":[58],"by":[59,76],"restriction":[60],"fragment":[61],"length":[62],"polymorphisms-PCR":[63],"assay":[64],"for":[66,156],"-1082A/G":[71,97],"gene":[75],"allele":[77,117],"specific\u2013":[78],"PCR.":[79],"RESULTS:":[80],"genotype":[82],"distribution":[83],"all":[85],"investigated":[86,143],"polymorphisms":[87,137,178],"(IL12Bpro":[88],"IL10)":[102],"similar":[107],"that":[109,160,174],"observed":[110],"control":[113],"group.":[114],"Respectively,":[115],"frequencies":[118],"did":[119],"not":[120,165,183],"show":[121],"significant":[122],"difference":[123],"between":[124,131],"cases":[125],"controls.":[127],"Lack":[128],"association":[130],"genotypes":[133],"studied":[136],"population":[145],"observed.":[147],"CONCLUSIONS:":[148],"In":[149],"our":[150,171,192],"case-control":[152],"study,":[153],"we":[154],"report":[155],"first":[158],"time":[159],"associated":[166,187],"development.":[169],"Also,":[170],"suggests":[173],"analyzed":[176],"genetic":[177],"cytokine":[180],"genes":[181],"do":[182],"appear":[184],"be":[186],"population.":[194]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}