{"id":"https://openalex.org/W2187688335","doi":null,"title":"Effect of Epilepsy and Antiepileptic Treatment on Reference and Working Memory","display_name":"Effect of Epilepsy and Antiepileptic Treatment on Reference and Working Memory","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2187688335","mag":"2187688335"},"language":"en","primary_location":{"id":"mag:2187688335","doi":null,"is_oa":false,"landing_page_url":"https://www.jscimedcentral.com/NeurologicalDisorders/neurologicaldisorders-spid-epilepsy-seizures-1065.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048554533","display_name":"Fructuoso Ayala\u2010Guerrero","orcid":"https://orcid.org/0000-0002-6029-3525","observed_orcids":["https://orcid.org/0000-0002-6029-3525"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fructuoso Ayala\u2010Guerrero","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6029-3525","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021921896","display_name":"Azalea Reyes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Azalea Reyes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027886165","display_name":"Graciela Mexicano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Graciela Mexicano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/temporal-lobe-epilepsy","display_name":"temporal lobe epilepsy","score":0.9549999833106995},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.8939999938011169},{"id":"https://openalex.org/keywords/phenobarbital","display_name":"phenobarbital","score":0.9860000014305115},{"id":"https://openalex.org/keywords/kainic-acid-model","display_name":"kainic acid model","score":0.890999972820282},{"id":"https://openalex.org/keywords/reference-memory","display_name":"reference memory","score":0.7820000052452087},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.996999979019165},{"id":"https://openalex.org/keywords/status-epilepticus","display_name":"status epilepticus","score":0.8450000286102295},{"id":"https://openalex.org/keywords/spatial-learning","display_name":"spatial learning","score":0.7110000252723694},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7300000190734863},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.7400000095367432},{"id":"https://openalex.org/keywords/hippocampal-sclerosis","display_name":"hippocampal sclerosis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.8423773646354675},{"id":"https://openalex.org/C2777341932","wikidata":"https://www.wikidata.org/wiki/Q980709","display_name":"Status epilepticus","level":3,"score":0.7715521454811096},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.7472341060638428},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6698671579360962},{"id":"https://openalex.org/C2776108384","wikidata":"https://www.wikidata.org/wiki/Q390239","display_name":"Kainic acid","level":4,"score":0.6153032183647156},{"id":"https://openalex.org/C2778793413","wikidata":"https://www.wikidata.org/wiki/Q407241","display_name":"Phenobarbital","level":2,"score":0.600307822227478},{"id":"https://openalex.org/C2777597344","wikidata":"https://www.wikidata.org/wiki/Q4421929","display_name":"Hippocampal sclerosis","level":4,"score":0.5675206780433655},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5447794198989868},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5290811657905579},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.4829367995262146},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.46112698316574097},{"id":"https://openalex.org/C57236427","wikidata":"https://www.wikidata.org/wiki/Q5382987","display_name":"Epileptogenesis","level":3,"score":0.44483017921447754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4003896117210388},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20234373211860657},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2187688335","doi":null,"is_oa":false,"landing_page_url":"https://www.jscimedcentral.com/NeurologicalDisorders/neurologicaldisorders-spid-epilepsy-seizures-1065.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W19003993","https://openalex.org/W69960442","https://openalex.org/W110360731","https://openalex.org/W1514567660","https://openalex.org/W1548050160","https://openalex.org/W1963689384","https://openalex.org/W1973789361","https://openalex.org/W1976033734","https://openalex.org/W1978331472","https://openalex.org/W1984214648","https://openalex.org/W1985394452","https://openalex.org/W1990015622","https://openalex.org/W1995460856","https://openalex.org/W2000341627","https://openalex.org/W2023584795","https://openalex.org/W2031155914","https://openalex.org/W2038680295","https://openalex.org/W2039668681","https://openalex.org/W2044682977","https://openalex.org/W2046525656","https://openalex.org/W2052529878","https://openalex.org/W2058230150","https://openalex.org/W2070532293","https://openalex.org/W2085251042","https://openalex.org/W2089816583","https://openalex.org/W2091722600","https://openalex.org/W2092700031","https://openalex.org/W2134273344","https://openalex.org/W2162129563","https://openalex.org/W2166248226","https://openalex.org/W2169798330","https://openalex.org/W2197459828","https://openalex.org/W2230449387","https://openalex.org/W2317133054"],"related_works":["https://openalex.org/W2188426299","https://openalex.org/W2124852494","https://openalex.org/W2012667903","https://openalex.org/W2040942445","https://openalex.org/W1981018013","https://openalex.org/W2025005466","https://openalex.org/W7045664772","https://openalex.org/W2371095681","https://openalex.org/W1975519512","https://openalex.org/W112777807"],"abstract_inverted_index":{"Epilepsy":[0,23],"is":[1,25,41,76],"one":[2,26,140],"of":[3,13,15,27,32,48,98,124,189,195,201,215],"the":[4,11,16,28,37,49,54,57,82,96,137,147,152,157,165,187],"most":[5,29],"frequent":[6],"neurological":[7],"alterations":[8,66,194],"affecting":[9],"significantly":[10],"quality":[12],"life":[14],"individuals":[17],"who":[18],"suffer":[19],"it.":[20],"Temporal":[21],"Lobe":[22],"(TLE)":[24],"severe":[30],"types":[31],"epilepsies":[33],"commonly":[34],"presented":[35],"in":[36,46,67,81,109,119],"world":[38,83],"population.":[39],"It":[40],"characterized":[42],"by":[43,169],"neuronal":[44],"damage":[45],"regions":[47],"limbic":[50],"system,":[51],"such":[52],"as":[53,114],"amygdala":[55],"and":[56,72,94,111,133,156,176,198,209],"hippocampus":[58],"(mesial":[59],"temporal":[60],"lobe":[61],"sclerosis).":[62],"These":[63,204],"lesions":[64],"provoke":[65],"cognitive":[68],"processes,":[69],"including":[70],"learning":[71,138],"memory.":[73,203],"Since":[74],"epilepsy":[75],"a":[77,128,213],"highly":[78],"prevalent":[79],"disease":[80],"population,":[84],"experimental":[85],"models":[86],"have":[87],"been":[88],"implemented":[89],"to":[90,106],"investigate":[91],"its":[92],"physiopathology":[93],"test":[95],"effectiveness":[97],"anticonvulsive":[99],"drugs.":[100],"The":[101],"Kainic":[102],"Acid":[103],"(KA)":[104],"model":[105],"produce":[107],"TLE":[108],"rats":[110,125],"phenobarbital":[112],"(PB)":[113],"antiepileptic":[115],"drug":[116],"were":[117,131],"used":[118,132],"this":[120],"study.":[121],"Four":[122],"groups":[123],"trained":[126],"on":[127,173],"spatial":[129],"task":[130],"once":[134],"they":[135],"met":[136],"criteria,":[139],"group":[141,149,159],"was":[142],"administered":[143,181],"with":[144,150,154,160],"saline":[145],"solution,":[146],"second":[148],"PB,":[151],"third":[153],"KA,":[155],"last":[158],"PB+KA.":[161],"Results":[162],"indicate":[163],"that":[164,207],"epileptic":[166],"seizures":[167],"induced":[168],"KA":[170,185],"produced":[171],"deficits":[172],"reference":[174,196,208],"(p<0.01)":[175],"working":[177,202,210],"memories":[178,211],"(p<0.001).":[179],"PB":[180],"30":[182],"minutes":[183],"prior":[184],"inhibited":[186],"development":[188],"status":[190],"epilepticus,":[191],"protected":[192],"against":[193],"memory":[197],"minimized":[199],"those":[200],"findings":[205],"suggest":[206],"are":[212],"part":[214],"different":[216],"functional":[217],"systems.":[218]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}