{"id":"https://openalex.org/W2187607367","doi":"https://doi.org/","title":"Attenuation of somatodendritic responses to 8-hydroxy-2-di-npropylamino tetralin following long-term dietary sugar consumption in rats.","display_name":"Attenuation of somatodendritic responses to 8-hydroxy-2-di-npropylamino tetralin following long-term dietary sugar consumption in rats.","publication_year":2009,"publication_date":"2009-07-01","ids":{"openalex":"https://openalex.org/W2187607367","doi":"https://doi.org/","mag":"2187607367","pmid":"https://pubmed.ncbi.nlm.nih.gov/19576144"},"language":"en","primary_location":{"id":"pmid:19576144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19576144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074487498","display_name":"Qurrat-ul-Aen Inam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Qurrat-Ul-Aen Inam","raw_affiliation_strings":["Department of Biochemistry, University of Karachi, Karachi. qurrat_biochemist@yahoo.com","Department of Biochemistry, University of Karachi, Karachi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Karachi, Karachi. qurrat_biochemist@yahoo.com","institution_ids":["https://openalex.org/I193670377"]},{"raw_affiliation_string":"Department of Biochemistry, University of Karachi, Karachi","institution_ids":["https://openalex.org/I193670377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113577906","display_name":"M.A. Haleem","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Abdul Haleem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019048394","display_name":"Darakhshan Jabeen Haleem","orcid":"https://orcid.org/0000-0003-4800-2198","observed_orcids":["https://orcid.org/0000-0003-4800-2198"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darakhshan Jabeen Haleem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3517,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.52255682,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"19","issue":"7","first_page":"401","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.7285000085830688,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.7285000085830688,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.2678000032901764,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/8-oh-dpat","display_name":"8-OH-DPAT","score":0.8949999809265137},{"id":"https://openalex.org/keywords/5-ht1a-receptor-agonist","display_name":"5-HT1A receptor agonist","score":0.8489999771118164},{"id":"https://openalex.org/keywords/high-sugar-diet","display_name":"high-sugar diet","score":0.7450000047683716},{"id":"https://openalex.org/keywords/hyperphagia","display_name":"hyperphagia","score":0.8510000109672546},{"id":"https://openalex.org/keywords/serotonin-metabolism","display_name":"serotonin metabolism","score":0.9359999895095825},{"id":"https://openalex.org/keywords/dietary-sugar","display_name":"dietary sugar","score":0.4860000014305115},{"id":"https://openalex.org/keywords/food-intake-regulation","display_name":"food intake regulation","score":0.5550000071525574},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.7427022457122803},{"id":"https://openalex.org/C2777108408","wikidata":"https://www.wikidata.org/wiki/Q11002","display_name":"Sugar","level":2,"score":0.6905645728111267},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6855466365814209},{"id":"https://openalex.org/C2776238416","wikidata":"https://www.wikidata.org/wiki/Q4644282","display_name":"8-OH-DPAT","level":5,"score":0.6817913055419922},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6350319385528564},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.6155022978782654},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.48906952142715454},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.45877373218536377},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45371612906455994},{"id":"https://openalex.org/C75908981","wikidata":"https://www.wikidata.org/wiki/Q28578","display_name":"Appetite","level":2,"score":0.4368237853050232},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.37459495663642883},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34819740056991577},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29608389735221863},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16033446788787842}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001069","descriptor_name":"Appetite Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006963","descriptor_name":"Hyperphagia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017371","descriptor_name":"8-Hydroxy-2-(di-n-propylamino)tetralin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019422","descriptor_name":"Dietary Sucrose","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D044263","descriptor_name":"Receptors, Serotonin, 5-HT1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:19576144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19576144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W53955850","https://openalex.org/W1566149803","https://openalex.org/W1887805002","https://openalex.org/W1968220189","https://openalex.org/W1992241048","https://openalex.org/W1992395370","https://openalex.org/W1995241918","https://openalex.org/W1996695079","https://openalex.org/W1996833453","https://openalex.org/W2026712024","https://openalex.org/W2029881171","https://openalex.org/W2033045982","https://openalex.org/W2046201137","https://openalex.org/W2046220668","https://openalex.org/W2051941023","https://openalex.org/W2052350817","https://openalex.org/W2058532060","https://openalex.org/W2069267673","https://openalex.org/W2075076661","https://openalex.org/W2075405314","https://openalex.org/W2099542131","https://openalex.org/W2149299024","https://openalex.org/W2154275960","https://openalex.org/W2475124104"],"related_works":["https://openalex.org/W1982343074","https://openalex.org/W2338616858","https://openalex.org/W4047603","https://openalex.org/W2290757569","https://openalex.org/W2475124104","https://openalex.org/W2061802657","https://openalex.org/W2000569639","https://openalex.org/W2099642680","https://openalex.org/W1982598585","https://openalex.org/W2082280930"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2],"changes":[3],"in":[4,24,71,153,167,180,188,195,204],"response":[5],"to":[6,44,115,163],"a":[7,110,175],"selective":[8],"serotonin-1A":[9],"receptor":[10],"agonist":[11],"8-hydroxy-2-(di-n-propylamino)":[12],"tetralin":[13],"(8-OH-DPAT)":[14],"following":[15],"long-term":[16],"consumption":[17],"of":[18,22,37,40,74,97,112,119,145,177,198],"sugar":[19,70,101,168,181],"as":[20],"part":[21],"meal":[23],"rats.":[25,57,157],"STUDY":[26],"DESIGN:":[27],"Experimental":[28],"study.":[29],"PLACE":[30],"AND":[31],"DURATION":[32],"OF":[33],"STUDY:":[34],"The":[35,48,158],"Department":[36],"Biochemistry,":[38],"University":[39],"Karachi,":[41],"from":[42],"June":[43],"August":[45],"2005.":[46],"METHODOLOGY:":[47],"study":[49],"was":[50,61,133],"conducted":[51],"on":[52,82,90,121],"24":[53],"male":[54],"albino":[55],"Wistar":[56],"Sugar":[58],"containing":[59],"diet":[60,67,102,155,171,182,206],"prepared":[62],"by":[63,140],"mixing":[64],"standard":[65,91],"rodent":[66,92],"and":[68,77,100,124,136,149,160],"table":[69],"the":[72,117,196],"ratio":[73],"3:1":[75],"(w/w)":[76],"rats":[78,86],"were":[79,87,105,138,165],"fed":[80,88],"freely":[81,89],"this":[83],"diet.":[84,93],"Control":[85],"After":[94],"five":[95],"weeks":[96],"treatment,":[98],"control":[99],"treated":[103,156,172,183],"animals":[104,173],"injected":[106],"with":[107],"8-OH-DPAT,":[108],"at":[109],"dose":[111],"0.5":[113],"mg/ml/kg,":[114],"monitor":[116],"effects":[118],"drug":[120],"food":[122],"intake":[123],"brain":[125],"serotonin":[126,189],"(5-hydroxytryptamine,":[127],"5-HT)":[128],"metabolism.":[129],"Dissected":[130],"neural":[131],"tissue":[132],"analyzed":[134],"electrochemically":[135],"findings":[137],"compared":[139],"Newman-Keuls":[141],"test.":[142],"RESULTS:":[143],"Administration":[144],"8-OH-DPAT":[146,164],"elicited":[147],"hyperphagia":[148],"decreased":[150],"5-HT":[151],"metabolism":[152,190],"normal":[154,170],"neurochemical":[159],"hyperphagic":[161],"responses":[162,179],"smaller":[166],"than":[169],"suggesting":[174],"downregulation":[176],"somatodendritic":[178,199],"animals.":[184],"CONCLUSION:":[185],"A":[186],"decrease":[187],"but":[191],"not":[192],"an":[193],"increase":[194],"responsiveness":[197],"5-HT-1A":[200],"receptors":[201],"is":[202],"involved":[203],"sugar-rich":[205],"induced":[207],"hyperphagia.":[208]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}