{"id":"https://openalex.org/W2187595952","doi":null,"title":"Interaction of -55CT polymorphism of UCP3 gene with Trp64Arg polymorphism of beta3adrenoreceptor gene on insulin resistance in obese patients.","display_name":"Interaction of -55CT polymorphism of UCP3 gene with Trp64Arg polymorphism of beta3adrenoreceptor gene on insulin resistance in obese patients.","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W2187595952","mag":"2187595952","pmid":"https://pubmed.ncbi.nlm.nih.gov/22774401"},"language":"en","primary_location":{"id":"pmid:22774401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22774401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076005842","display_name":"Daniel Antonio de Luis","orcid":"https://orcid.org/0000-0002-1745-9315","observed_orcids":["https://orcid.org/0000-0002-1745-9315"]},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]},{"id":"https://openalex.org/I4210158107","display_name":"Hospital Universitario R\u00edo Hortega","ror":"https://ror.org/05jk45963","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158107"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"D A de Luis","raw_affiliation_strings":["Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain RD056/0001 3RETICEF. dadluis@yahoo.es","Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain RD056/0001 3RETICEF"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain RD056/0001 3RETICEF. dadluis@yahoo.es","institution_ids":["https://openalex.org/I108103353","https://openalex.org/I4210158107"]},{"raw_affiliation_string":"Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain RD056/0001 3RETICEF","institution_ids":["https://openalex.org/I108103353","https://openalex.org/I4210158107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110131905","display_name":"R. Aller","orcid":"https://orcid.org/0000-0002-6795-4541","observed_orcids":["https://orcid.org/0000-0002-6795-4541"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Aller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007905745","display_name":"Olatz Izaola","orcid":"https://orcid.org/0000-0003-1201-4875","observed_orcids":["https://orcid.org/0000-0003-1201-4875"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Izaola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067155686","display_name":"Manuel Gonzalez Sagrado","orcid":"https://orcid.org/0000-0001-9878-3776","observed_orcids":["https://orcid.org/0000-0001-9878-3776"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Gonzalez Sagrado","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037511818","display_name":"Rosa Conde","orcid":"https://orcid.org/0000-0002-6636-5729","observed_orcids":["https://orcid.org/0000-0002-6636-5729"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Conde","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109309598","display_name":"Castro Mj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Castro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8799,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.70691566,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"16","issue":"5","first_page":"610","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.13950000703334808,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.09130000323057175,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ucp3-gene","display_name":"UCP3 gene","score":0.8149999976158142},{"id":"https://openalex.org/keywords/gene-gene-interaction","display_name":"gene-gene interaction","score":0.8650000095367432},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9660000205039978},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.996999979019165},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.6769999861717224},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.9010000228881836},{"id":"https://openalex.org/keywords/adiposity","display_name":"adiposity","score":0.5049999952316284},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7170000076293945},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7762376070022583},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.746370792388916},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6925254464149475},{"id":"https://openalex.org/C2776193436","wikidata":"https://www.wikidata.org/wiki/Q236232","display_name":"Waist","level":3,"score":0.6738943457603455},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5924041271209717},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5425633788108826},{"id":"https://openalex.org/C33997684","wikidata":"https://www.wikidata.org/wiki/Q876152","display_name":"Waist\u2013hip ratio","level":4,"score":0.5174232721328735},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.5153031349182129},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4695112407207489},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2864576578140259},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15748539566993713},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11085978150367737}],"mesh":[{"descriptor_ui":"D000071247","descriptor_name":"Uncoupling Protein 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013030","descriptor_name":"Spain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017097","descriptor_name":"Electric Impedance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022702","descriptor_name":"Receptors, Adrenergic, beta-3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049629","descriptor_name":"Waist-Hip Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050154","descriptor_name":"Adiposity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054392","descriptor_name":"Adipokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D055105","descriptor_name":"Waist Circumference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22774401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22774401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},{"id":"mag:2187595952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22774401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1967359474","https://openalex.org/W1993577469","https://openalex.org/W1996302892","https://openalex.org/W2020284058","https://openalex.org/W2023530279","https://openalex.org/W2031161073","https://openalex.org/W2037810301","https://openalex.org/W2051123965","https://openalex.org/W2056497781","https://openalex.org/W2058079431","https://openalex.org/W2079185127","https://openalex.org/W2087754123","https://openalex.org/W2093691904","https://openalex.org/W2109555667","https://openalex.org/W2129719175","https://openalex.org/W2152585262","https://openalex.org/W2160234571","https://openalex.org/W2164190249","https://openalex.org/W2333558047","https://openalex.org/W2408913104"],"related_works":["https://openalex.org/W2135490116","https://openalex.org/W4380045953","https://openalex.org/W2079830178","https://openalex.org/W2605904174","https://openalex.org/W2047374104","https://openalex.org/W2058302318","https://openalex.org/W2066768128","https://openalex.org/W2140182926","https://openalex.org/W2138020946","https://openalex.org/W2184953315"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"aim":[2],"of":[3,11,37,52,165],"our":[4],"study":[5],"was":[6,41],"to":[7,148,175],"investigate":[8],"the":[9,17,24,64,85],"interaction":[10],"tryptophan-to-arginine":[12],"(Trp64Arg)":[13],"missense":[14],"mutation":[15,198],"in":[16,23,31,183,195],"beta3":[18],"adrenoreceptor":[19],"(Beta3AR)":[20],"with":[21,109,132,185],"polymorphism":[22],"UCP3":[25],"promotor":[26],"(-55C->T)":[27],"on":[28],"insulin":[29],"resistance":[30],"obese":[32,39],"patients.":[33,130],"DESIGN:":[34],"A":[35,43],"population":[36],"212":[38],"patients":[40,61,72,93,100,184,196],"analyzed.":[42],"bipolar":[44],"electrical":[45],"bioimpedance,":[46],"a":[47],"biochemical":[48],"analysis":[49],"and":[50,59,70,80,91,106,124,136,154,178],"concentrations":[51,164],"adipocytokines":[53],"were":[54,181],"assessed.":[55],"RESULTS:":[56],"One":[57,78],"hundred":[58,79],"sixty-two":[60],"(76.4%)":[62],"had":[63,84,102,115,139],"genotype":[65,86,138,187],"Trp64/Trp64":[66],"(wild":[67,88],"type":[68,76,89,97,129,158],"group)":[69,90],"50":[71],"Trp64/Arg64":[73,105],"(23.6%)":[74],"(mutant":[75,96],"group).":[77,98],"seventy":[81],"five":[82],"(87.2%)":[83],"-55CC":[87],"27":[92],"(22.8%)":[94],"-55CT":[95,186,190],"Five":[99],"(2.4%)":[101],"both":[103,112],"polymorphisms":[104],"-55CT.":[107],"Patients":[108,131],"one":[110],"or":[111,134,159,189,199],"mutant":[113],"genotypes":[114,193],"higher":[116,140],"BMI,":[117,141,170],"weight,":[118,142,171],"fat":[119,143,172],"mass,":[120,144,173],"systolic":[121],"blood":[122],"pressure":[123],"waist":[125,145,147,174,179],"circumference":[126,180],"than":[127,156,194],"wild":[128,157],"55CT":[133,135],"Trp64Arg":[137,160,192,201],"circumference,":[146],"hip":[149,176],"ratio":[150,177],"glucose,":[151,169],"insulin,":[152,166],"triglycerides":[153],"HOMA":[155],"mutation.":[161,202],"CONCLUSION:":[162],"Higher":[163],"HOMA,":[167],"triglycerides,":[168],"observed":[182],"alone":[188],"plus":[191],"without":[197],"only":[200]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
