{"id":"https://openalex.org/W2187533666","doi":null,"title":"Phenotypical Changes of the Pulmonary Artery Endothelial Cells in Fetal Sheep Model of Persistent Pulmonary Hypertension of the Newborn","display_name":"Phenotypical Changes of the Pulmonary Artery Endothelial Cells in Fetal Sheep Model of Persistent Pulmonary Hypertension of the Newborn","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2187533666","mag":"2187533666"},"language":"en","primary_location":{"id":"mag:2187533666","doi":null,"is_oa":false,"landing_page_url":"http://www.jscimedcentral.com/ExperimentalHypertension/experimentalhypertension-3-1025.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068363919","display_name":"Ru\u2010Jeng Teng","orcid":"https://orcid.org/0000-0003-4321-2452","observed_orcids":["https://orcid.org/0000-0003-4321-2452"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ru\u2010Jeng Teng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4321-2452","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112185962","display_name":"Tzong-Jin Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tzong-Jin Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.1808999925851822,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12272","display_name":"Cardiovascular Conditions and Treatments","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-artery-endothelial-cells","display_name":"pulmonary artery endothelial cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/fetal-sheep-model","display_name":"fetal sheep model","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ductus-arteriosus-constriction","display_name":"ductus arteriosus constriction","score":0.9879999756813049},{"id":"https://openalex.org/keywords/endothelial-phenotype","display_name":"endothelial phenotype","score":0.6800000071525574},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9980000257492065},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.9229999780654907},{"id":"https://openalex.org/keywords/neonatal-lung-disease","display_name":"neonatal lung disease","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.8086569905281067},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.7955864667892456},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7744526863098145},{"id":"https://openalex.org/C2781236024","wikidata":"https://www.wikidata.org/wiki/Q1163923","display_name":"Ductus arteriosus","level":2,"score":0.731339693069458},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.6486678719520569},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5385677814483643},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49598583579063416},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.47592809796333313},{"id":"https://openalex.org/C174940676","wikidata":"https://www.wikidata.org/wiki/Q495626","display_name":"Constriction","level":2,"score":0.44814369082450867},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.41409990191459656},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.21722301840782166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11360019445419312},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2187533666","doi":null,"is_oa":false,"landing_page_url":"http://www.jscimedcentral.com/ExperimentalHypertension/experimentalhypertension-3-1025.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1770314811","https://openalex.org/W1979637750","https://openalex.org/W1991559556","https://openalex.org/W1991814569","https://openalex.org/W1994718097","https://openalex.org/W2007145217","https://openalex.org/W2029658224","https://openalex.org/W2039495243","https://openalex.org/W2060706139","https://openalex.org/W2060770407","https://openalex.org/W2081079073","https://openalex.org/W2103017262","https://openalex.org/W2121863476","https://openalex.org/W2129166389","https://openalex.org/W2133517534","https://openalex.org/W2163920654"],"related_works":["https://openalex.org/W2970402226","https://openalex.org/W1982339972","https://openalex.org/W2021851567","https://openalex.org/W2051511057","https://openalex.org/W4322728293","https://openalex.org/W4412303343","https://openalex.org/W174622203","https://openalex.org/W3045263189","https://openalex.org/W7095246176","https://openalex.org/W2149306197"],"abstract_inverted_index":{"Persistent":[0],"pulmonary":[1,50,80,85,104,124],"artery":[2,51,81,105,125],"hypertension":[3,86,126],"of":[4,64,90,121,127],"the":[5,35,119,122,128,141],"newborn":[6,129],"is":[7,34,75],"a":[8,62,76],"common":[9],"lung":[10],"disorder":[11],"in":[12,16,31,98,143],"neonates":[13],"affecting":[14],"one":[15],"every":[17],"500":[18],"live":[19],"births":[20],"with":[21,79,87],"high":[22],"mortality":[23],"and":[24],"morbidity":[25],"rates.":[26],"Intrauterine":[27],"ductus":[28],"arteriosus":[29],"constriction":[30],"fetal":[32],"sheep":[33],"most":[36],"commonly":[37],"used":[38],"animal":[39,57,110],"model":[40,58,111],"to":[41,67,96,117,139],"study":[42,138],"this":[43,56,69,109],"disease":[44,142],"entity.":[45],"In":[46],"vitro":[47],"studies":[48],"using":[49,103],"endothelial":[52,82,106],"cells":[53,83,107],"obtained":[54],"from":[55,108],"have":[59],"provided":[60],"us":[61,114],"lot":[63],"important":[65],"information":[66],"understand":[68],"disease.":[70],"Evidence":[71],"suggests":[72],"that":[73,94,135],"there":[74],"phenotypical":[77],"change":[78],"under":[84],"increased":[88],"formation":[89],"reactive":[91],"oxygen":[92],"species":[93],"lead":[95],"changes":[97],"several":[99],"signaling":[100],"pathways.":[101],"Research":[102],"can":[112,137],"help":[113],"not":[115],"only":[116],"understanding":[118],"Pathophysiology":[120],"persistent":[123],"but":[130],"also":[131],"finding":[132],"new":[133],"targets":[134],"we":[136],"treat":[140],"human":[144],"neonates.":[145]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}