{"id":"https://openalex.org/W2187520922","doi":null,"title":"CURRENT IMPLICATIONS FOR CANCER DETECTION, PREVENTION, AND THERAPEUTICS*","display_name":"CURRENT IMPLICATIONS FOR CANCER DETECTION, PREVENTION, AND THERAPEUTICS*","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2187520922","mag":"2187520922"},"language":"en","primary_location":{"id":"mag:2187520922","doi":null,"is_oa":false,"landing_page_url":"http://www.bio.mtu.edu/%7Ehlyoungs/BL4010/krueger-srivastava-PTM.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055046548","display_name":"Karl E. Krueger","orcid":"https://orcid.org/0009-0005-5090-3982","observed_orcids":["https://orcid.org/0009-0005-5090-3982"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karl E. Krueger","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-5090-3982","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101623259","display_name":"Sudhir Srivastava","orcid":"https://orcid.org/0000-0002-7798-9772","observed_orcids":["https://orcid.org/0000-0002-7798-9772"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sudhir Srivastava","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7798-9772","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.8461999893188477,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.8461999893188477,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.925000011920929},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cancer-detection","display_name":"cancer detection","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.984000027179718},{"id":"https://openalex.org/keywords/cancer-therapeutics","display_name":"cancer therapeutics","score":0.8059999942779541},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5460000038146973},{"id":"https://openalex.org/keywords/oncogenic-signaling","display_name":"oncogenic signaling","score":0.6520000100135803},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.609000027179718},{"id":"https://openalex.org/keywords/early-stage-cancer","display_name":"early-stage cancer","score":0.5580000281333923},{"id":"https://openalex.org/keywords/translational-cancer-research","display_name":"translational oncology","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.584142804145813},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5571571588516235},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5337302088737488},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.49085885286331177},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.4679132103919983},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.4589061141014099},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4578624367713928},{"id":"https://openalex.org/C2780234812","wikidata":"https://www.wikidata.org/wiki/Q1787013","display_name":"Cancer prevention","level":3,"score":0.4339803159236908},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3717741370201111},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35362130403518677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.311176598072052},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.1177625060081482},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10007226467132568},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09651044011116028},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09093496203422546},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2187520922","doi":null,"is_oa":false,"landing_page_url":"http://www.bio.mtu.edu/%7Ehlyoungs/BL4010/krueger-srivastava-PTM.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W1487258982","https://openalex.org/W1503515712","https://openalex.org/W1511973051","https://openalex.org/W1521353297","https://openalex.org/W1569610737","https://openalex.org/W1780544763","https://openalex.org/W1878812720","https://openalex.org/W1911118961","https://openalex.org/W1933105316","https://openalex.org/W1965090530","https://openalex.org/W1965493433","https://openalex.org/W1967744862","https://openalex.org/W1969324876","https://openalex.org/W1976873804","https://openalex.org/W1983202503","https://openalex.org/W1993263392","https://openalex.org/W2002191009","https://openalex.org/W2002937040","https://openalex.org/W2003984225","https://openalex.org/W2008985446","https://openalex.org/W2010784970","https://openalex.org/W2014142027","https://openalex.org/W2014440272","https://openalex.org/W2019555346","https://openalex.org/W2029487801","https://openalex.org/W2038626735","https://openalex.org/W2043696829","https://openalex.org/W2044535505","https://openalex.org/W2045027538","https://openalex.org/W2046370400","https://openalex.org/W2046675842","https://openalex.org/W2051740728","https://openalex.org/W2055525267","https://openalex.org/W2064937786","https://openalex.org/W2070705072","https://openalex.org/W2075325266","https://openalex.org/W2079968296","https://openalex.org/W2080289465","https://openalex.org/W2081928833","https://openalex.org/W2082225843","https://openalex.org/W2087152593","https://openalex.org/W2090561517","https://openalex.org/W2093188317","https://openalex.org/W2095561162","https://openalex.org/W2097590048","https://openalex.org/W2098619516","https://openalex.org/W2099046152","https://openalex.org/W2099467735","https://openalex.org/W2104743043","https://openalex.org/W2108178331","https://openalex.org/W2109678955","https://openalex.org/W2114063466","https://openalex.org/W2121328777","https://openalex.org/W2121802781","https://openalex.org/W2126436436","https://openalex.org/W2129496479","https://openalex.org/W2131492616","https://openalex.org/W2136735139","https://openalex.org/W2138297714","https://openalex.org/W2139236349","https://openalex.org/W2140513457","https://openalex.org/W2140942363","https://openalex.org/W2141149378","https://openalex.org/W2143658931","https://openalex.org/W2147105537","https://openalex.org/W2150312232","https://openalex.org/W2153477391","https://openalex.org/W2156307820","https://openalex.org/W2161821474","https://openalex.org/W2162809593","https://openalex.org/W2167118090","https://openalex.org/W2167602049","https://openalex.org/W2227399362","https://openalex.org/W3148685323"],"related_works":["https://openalex.org/W7098255142","https://openalex.org/W7097419624","https://openalex.org/W2032232569","https://openalex.org/W7098236831","https://openalex.org/W3034533350","https://openalex.org/W7042886635","https://openalex.org/W7155399569","https://openalex.org/W2245728700","https://openalex.org/W7160017097","https://openalex.org/W1788506364"],"abstract_inverted_index":{"Over":[0],"the":[1,16,36,49,64,92,119,141,154,230,294,308,330,349,367,389],"last":[2],"several":[3,180],"years":[4],"major":[5,390],"advances":[6],"in":[7,15,48,160,169,186,223,235,253,298,337,384,423,435],"sensitive":[8],"high":[9],"throughput":[10],"technologies":[11,191,258],"have":[12],"been":[13,140,221],"made":[14,222],"fields":[17],"of":[18,41,54,67,82,87,91,104,128,143,174,200,211,263,269,278,310,316,339,354,366,373,381,392],"genomics":[19,42,116],"and":[20,26,39,43,202,238,281,344,360,415],"proteomics.":[21],"The":[22,79,172],"hunt":[23],"for":[24,51,106,209,265,357,421],"diagnostic":[25],"prognostic":[27],"cancer":[28,187,236,245,319,342,358,413,436],"biomarkers":[29],"exploits":[30],"these":[31,58,379],"recent":[32,37,276],"technology":[33],"platforms.":[34,117],"Although":[35],"developments":[38,225,277],"use":[40],"proteomics":[44,114],"offer":[45,101],"much":[46],"promise":[47],"search":[50],"molecular":[52],"markers":[53],"early":[55],"stage":[56],"cancers,":[57],"methods":[59],"are":[60,271,332,353,409,428,438],"inadequate":[61],"to":[62,76,121,153,178,195,226,259,303,318,334,341,411,432],"probe":[63],"dynamic":[65],"nature":[66],"signaling":[68,94],"processes":[69],"that":[70,109,131,216,257,407,427],"cells":[71],"exhibit":[72],"during":[73,97],"their":[74,240],"transformation":[75],"become":[77],"neoplastic.":[78],"diverse":[80],"realm":[81],"posttranslational":[83],"modification":[84,270],"(PTM)":[85],"1":[86],"proteins":[88,315,375],"encompasses":[89],"many":[90,365,397],"critical":[93],"events":[95],"occurring":[96],"neoplastic":[98],"transformation.":[99],"PTMs":[100,183,205,352,393,408,426],"a":[102,133,162,244,266],"plethora":[103],"candidates":[105],"biomarker":[107,246,304],"detection":[108,199,343],"complement":[110],"discoveries":[111],"using":[112],"strictly":[113],"or":[115,198,247],"Furthermore":[118],"potential":[120],"pharmacologically":[122],"impede":[123],"tumor":[124],"growth":[125],"by":[126,157,323,396],"administration":[127],"an":[129],"agent":[130],"interrupts":[132],"specific":[134,279,314,374],"PTM":[135,254,289,299,372],"driving":[136],"oncogenic":[137],"progression":[138],"has":[139,220,306,376],"basis":[142],"numerous":[144],"clinical":[145,196,382,433],"trials":[146],"currently":[147,394,429],"underway.":[148],"To":[149],"draw":[150],"greater":[151],"attention":[152,420],"opportunities":[155],"afforded":[156],"innovative":[158],"research":[159,255,297],"PTMs,":[161,228],"2-day":[163],"workshop":[164],"was":[165],"conducted":[166],"August":[167],"2002":[168],"Bethesda,":[170],"MD.":[171],"goals":[173],"this":[175,401],"meeting":[176],"were":[177],"address":[179],"topics":[181],"where":[182,351,371],"play":[184,234],"roles":[185,232],"progression,":[188,237],"consider":[189],"what":[190,204],"can":[192],"be":[193,207,335,405],"applied":[194],"prevention":[197],"cancer,":[201],"assess":[203],"could":[206],"pursued":[208],"development":[210],"promising":[212],"surrogate":[213],"markers.":[214],"Since":[215],"time":[217],"some":[218],"advancement":[219],"technological":[224],"study":[227,309],"identifying":[229],"central":[231],"they":[233],"determining":[239],"amenability":[241],"as":[242,300],"either":[243],"therapeutic":[248],"target.":[249],"A":[250],"limiting":[251],"factor":[252],"is":[256],"screen":[260],"vast":[261],"numbers":[262],"molecules":[264],"particular":[267],"type":[268],"often":[272],"not":[273,333],"available,":[274],"although":[275],"probes":[280],"multiplexed":[282],"platforms":[283],"may":[284],"now":[285],"make":[286],"broader":[287],"scale":[288],"surveying":[290],"feasible":[291],"(1\u20136).":[292],"For":[293],"most":[295,430],"part,":[296],"it":[301,403],"relates":[302],"discovery":[305],"required":[307],"discreet":[311],"modifications":[312],"on":[313],"importance":[317,356],"biology.":[320],"This":[321,346,386],"one":[322,324],"approach":[325],"clearly":[326],"takes":[327],"time,":[328],"but":[329],"rewards":[331],"underestimated":[336],"terms":[338],"application":[340],"treatment.":[345,361],"review":[347,387],"highlights":[348,388],"areas":[350],"prime":[355],"diagnosis":[359],"Table":[362],"I":[363],"lists":[364],"more":[368],"prominent":[369],"examples":[370],"relevance":[377],"toward":[378],"aspects":[380,391],"practice":[383],"oncology.":[385],"investigated":[395],"laboratories.":[398],"By":[399],"providing":[400],"overview,":[402],"should":[404,417],"apparent":[406],"key":[410],"understanding":[412],"biology":[414],"thus":[416],"receive":[418],"special":[419],"applications":[422,434],"translational":[424],"research.":[425],"germane":[431],"medicine":[437],"briefly":[439],"introduced":[440],"below.":[441]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
