{"id":"https://openalex.org/W2187451606","doi":null,"title":"Mechanisms of Apoptosis Modulation and their Contribution to Genomic Instability in Tumor Cells","display_name":"Mechanisms of Apoptosis Modulation and their Contribution to Genomic Instability in Tumor Cells","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2187451606","mag":"2187451606"},"language":"en","primary_location":{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-012945003","doi":null,"is_oa":false,"landing_page_url":"https://nbn-resolving.org/nbn:de:bvb:20-opus-10605","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Hochschulschrift"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/914","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109188324","display_name":"Vladimir Vuki\u0107evi\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vladimir Vuki\u0107evi\u0107","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109188324"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cancer-cells","display_name":"cancer cells","score":0.7620000243186951},{"id":"https://openalex.org/keywords/genotoxic-stress","display_name":"genotoxic stress","score":0.6840000152587891},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.6079999804496765},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.5849999785423279},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.5600000023841858},{"id":"https://openalex.org/keywords/apoptosis-signaling-pathway","display_name":"apoptosis signaling","score":0.5239999890327454},{"id":"https://openalex.org/keywords/ced-9","display_name":"CED-9","score":0.6919999718666077},{"id":"https://openalex.org/keywords/ced-3","display_name":"CED-3","score":0.8999999761581421},{"id":"https://openalex.org/keywords/ced-4","display_name":"CED-4","score":0.9649999737739563},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.6840000152587891},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.8930000066757202},{"id":"https://openalex.org/keywords/apaf-1","display_name":"Apaf-1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5820000171661377},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5946508049964905},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.5794901251792908},{"id":"https://openalex.org/C207821765","wikidata":"https://www.wikidata.org/wiki/Q405372","display_name":"Instability","level":2,"score":0.5718016028404236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.427101731300354},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3899879455566406},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3601865768432617},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2874335050582886},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24954169988632202},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2131621241569519},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.17597299814224243},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.09277600049972534}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-012945003","doi":null,"is_oa":false,"landing_page_url":"https://nbn-resolving.org/nbn:de:bvb:20-opus-10605","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Hochschulschrift"},{"id":"pmh:oai:opus.bibliothek.uni-wuerzburg.de:914","doi":null,"is_oa":true,"landing_page_url":"https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/914","pdf_url":null,"source":{"id":"https://openalex.org/S4306401635","display_name":"Online Publication Service of W\u00fcrzburg University (W\u00fcrzburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I25974101","host_organization_name":"University of W\u00fcrzburg","host_organization_lineage":["https://openalex.org/I25974101"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doctoralthesis"},{"id":"mag:2187451606","doi":null,"is_oa":false,"landing_page_url":"https://opus.bibliothek.uni-wuerzburg.de/files/914/Vukicevic_PhD_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:opus.bibliothek.uni-wuerzburg.de:914","doi":null,"is_oa":true,"landing_page_url":"https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/914","pdf_url":null,"source":{"id":"https://openalex.org/S4306401635","display_name":"Online Publication Service of W\u00fcrzburg University (W\u00fcrzburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I25974101","host_organization_name":"University of W\u00fcrzburg","host_organization_lineage":["https://openalex.org/I25974101"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doctoralthesis"},"sustainable_development_goals":[{"score":0.766700029373169,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W6853850","https://openalex.org/W20768369","https://openalex.org/W76372439","https://openalex.org/W1604468403","https://openalex.org/W1642763135","https://openalex.org/W1965553853","https://openalex.org/W1971287536","https://openalex.org/W1974383277","https://openalex.org/W1976533028","https://openalex.org/W1977819753","https://openalex.org/W1983271516","https://openalex.org/W1985981279","https://openalex.org/W1986303971","https://openalex.org/W1988355439","https://openalex.org/W1989249112","https://openalex.org/W1990658681","https://openalex.org/W1995648202","https://openalex.org/W2003110709","https://openalex.org/W2004008931","https://openalex.org/W2005333148","https://openalex.org/W2008362639","https://openalex.org/W2014194664","https://openalex.org/W2015494582","https://openalex.org/W2016599680","https://openalex.org/W2019179449","https://openalex.org/W2025793548","https://openalex.org/W2027600073","https://openalex.org/W2030331053","https://openalex.org/W2032770280","https://openalex.org/W2033191623","https://openalex.org/W2040881358","https://openalex.org/W2044079387","https://openalex.org/W2057983992","https://openalex.org/W2060618478","https://openalex.org/W2069182261","https://openalex.org/W2070953612","https://openalex.org/W2079384901","https://openalex.org/W2081915382","https://openalex.org/W2082178076","https://openalex.org/W2083087888","https://openalex.org/W2084475506","https://openalex.org/W2086708203","https://openalex.org/W2088027529","https://openalex.org/W2095236624","https://openalex.org/W2098376068","https://openalex.org/W2106493014","https://openalex.org/W2108172661","https://openalex.org/W2113823618","https://openalex.org/W2114333809","https://openalex.org/W2130603065","https://openalex.org/W2135310333","https://openalex.org/W2136490830","https://openalex.org/W2139812988","https://openalex.org/W2140294274","https://openalex.org/W2153403197","https://openalex.org/W2153918480","https://openalex.org/W2153980143","https://openalex.org/W2161467578","https://openalex.org/W2161616089","https://openalex.org/W2167908994","https://openalex.org/W2182756033","https://openalex.org/W2315283231","https://openalex.org/W2398314165"],"related_works":["https://openalex.org/W194418407","https://openalex.org/W1004459774","https://openalex.org/W2046009688","https://openalex.org/W2140894399","https://openalex.org/W7164646999","https://openalex.org/W149197731","https://openalex.org/W1963500688","https://openalex.org/W2260570064","https://openalex.org/W2053954735","https://openalex.org/W2409487472"],"abstract_inverted_index":{"The":[0,39,415],"concept":[1],"of":[2,18,57,139,164,241,253,286,296,303,321,330,339,366,380,390,395,410,471,485,563,580],"programmed":[3],"cell":[4,44,58,130,176,197,242,412,429,494,536,546,572],"death":[5,131,198,243,287],"has":[6],"been":[7],"increasingly":[8,30],"considered":[9],"from":[10],"various":[11],"aspects":[12],"since":[13],"early":[14],"1970\u2019s.":[15],"Primarily,":[16],"knowledge":[17],"apoptosis":[19,66,89,99,270,372,396,457,584],"referred":[20],"to":[21,79,93,103,144,181,317,369,384,425,448,524],"morphological":[22,247],"changes":[23,248],"in":[24,36,62,154,175,185,206,209,263,310,337,353,359,428,437,469,475,534,543,569,588],"which":[25],"chromatin":[26],"is":[27,67,91,109,199,237,383,418,463],"condensed":[28],"and":[29,42,90,96,100,106,117,135,147,158,169,224,249,289,328,356,393,442,451,458,510,531,566,585],"fragmented,":[31],"revealed":[32],"as":[33,47,126,300,325,440],"small":[34],"structure":[35],"the":[37,43,179,210,264,301,311,364,378,386,408,445,454,517,526,564,578],"nucleus.":[38],"membrane":[40,246],"shrinks":[41],"becomes":[45],"dense":[46],"can":[48,342],"be":[49],"seen":[50],"by":[51,192,227,245,251,559],"flow":[52],"cytometry.":[53],"Interestingly,":[54],"similar":[55],"modes":[56],"deletion":[59],"were":[60,142,488,500,554],"observed":[61],"nematodes":[63],"indicating":[64],"that":[65,141,166,259,267,278,348,478],"a":[68,114,151,200,238,318,344,350,411,426],"highly":[69,115],"conserved":[70],"machinery.":[71],"Three":[72],"Caeonorhabditis":[73],"elegans":[74],"gene":[75],"products":[76],"are":[77,101,225,271,404],"found":[78],"have":[80],"high":[81],"homology":[82],"with":[83,284,294,496,507,512,538,548,592],"mammalian":[84],"apoptotic":[85,183,223,281,291,313,346,481,532],"genes:":[86],"CED-9":[87],"inhibits":[88],"related":[92,102],"bcl-2;":[94],"CED-3":[95],"CED-4":[97],"promote":[98],"caspase":[104],"9":[105],"APAF-1.":[107],"Apoptosis":[108,161],"not":[110,467],"accidental":[111],"death,":[112],"but":[113],"controlled":[116],"medically":[118],"important":[119],"molecular":[120],"process.":[121],"More":[122,362],"general":[123],"terms":[124],"such":[125,220,299,324,439],"\u2018physiological\u2019":[127],"or":[128,172,306,466,542],"\u2018regulated\u2019":[129],"cover":[132],"different":[133,405,522,539],"morphologies":[134],"sequences.":[136],"Programmed":[137,196],"suicide":[138],"cells":[140,187,368,591],"subjected":[143],"toxic":[145],"exogenous":[146],"endogenous":[148],"stimuli":[149],"plays":[150,349],"key":[152],"role":[153,352],"understanding":[155],"cancer":[156,186,367,535],"development":[157],"its":[159],"treatment.":[160,361],"involves":[162],"sequences":[163],"events":[165],"may":[167,215,260,268,315,452],"overlap":[168],"play":[170],"contradictory":[171],"antagonistic":[173],"roles":[174],"death.":[177],"Generally,":[178,377],"ability":[180],"trigger":[182],"processes":[184],"would":[188],"benefit":[189],"an":[190],"organism":[191],"keeping":[193],"homeostasis":[194,298],"intact.":[195],"regularly":[201],"present":[202,518],"mechanism,":[203],"for":[204,407],"instance,":[205],"lymphocyte":[207],"recruitment":[208],"thymus":[211],"where":[212],"immature":[213],"lymphocytes":[214,221],"recognize":[216],"host":[217],"antigens.":[218],"Therefore,":[219],"become":[222],"removed":[226],"macrophages.":[228],"Removal":[229],"prevents":[230,373],"possible":[231],"autoimmune":[232],"diseases.":[233],"Unlike":[234],"apoptosis,":[235],"necrosis":[236],"passive":[239],"process":[240],"recognizable":[244],"accompanied":[250],"leakage":[252],"intracellular":[254,297],"material":[255],"into":[256,274,371],"intercellular":[257],"space":[258],"cause":[261,343],"inflammation":[262],"organism.":[265],"Signals":[266],"initiate":[269],"generally":[272],"classified":[273],"two":[275],"groups:":[276],"signals":[277,314],"launch":[279],"extrinsic":[280],"pathways":[282,292],"starting":[283,293],"aggregation":[285],"receptors":[288],"intrinsic":[290],"disruption":[295],"release":[302],"mitochondrial":[304],"factors":[305],"DNA":[307,326,331,433,486,529,586],"degradation.":[308],"Early":[309],"process,":[312],"lead":[316],"broad":[319],"range":[320],"signaling":[322],"mechanisms":[323],"repair":[327],"assessment":[329],"damage":[332,392,487,530,587],"(check":[333],"points).":[334],"Thus,":[335],"failure":[336],"any":[338],"these":[340],"steps":[341],"defective":[345],"response":[347,447,482],"decisive":[351],"both":[354],"tumorigenesis":[355],"drug":[357],"resistance":[358],"tumor":[360],"distinctly,":[363],"capability":[365],"go":[370],"further":[374],"neoplastic":[375],"changes.":[376],"purpose":[379],"this":[381,491],"study":[382],"investigate":[385,525],"balance":[387,455],"between":[388,456,528],"formation":[389],"genomic":[391,416,459],"induction":[394,484],"under":[397],"genotoxic":[398,401,449],"stress.":[399],"After":[400],"insult":[402],"there":[403],"possibilities":[406],"fate":[409],"(Figure":[413],"1).":[414],"integrity":[417],"analyzed":[419],"at":[420],"cellular":[421,446],"checkpoints,":[422],"usually":[423,464],"leading":[424],"delay":[427],"cycle":[430],"progression":[431],"if":[432],"was":[434],"damaged.":[435],"Mutations":[436],"genes":[438],"p53":[441,462,476,498,509,540,565],"p21":[443],"change":[444],"stress":[450],"alter":[453],"damage.":[460],"However,":[461],"mutated":[465,508],"expressed":[468,550],"70%":[470],"human":[472,570],"tumors.":[473],"Alterations":[474],"states":[477,499,541],"reflect":[479],"distinct":[480,497],"upon":[483],"examined.":[489],"In":[490,516,574],"study,":[492],"three":[493],"lines":[495,537,547],"used:":[501],"TK6":[502],"harboring":[503],"wild-type":[504],"p53,":[505],"WTK1":[506],"NH32":[511],"knocked":[513],"out":[514],"p53.":[515],"work":[519],"we":[520,576],"applied":[521],"approaches":[523],"correlation":[527],"responsiveness":[533],"hormone":[544],"responsive":[545],"over":[549],"bcl-2":[551],"gene.":[552],"We":[553],"focused":[555],"on":[556,583],"effects":[557],"caused":[558],"temporary":[560],"down":[561],"regulation":[562],"Bcl-2":[567],"activity":[568],"lymphoblastoid":[571],"lines.":[573],"addition,":[575],"investigated":[577],"impact":[579],"estradiol-induced":[581],"proliferation":[582],"stably":[589],"transfected":[590],"bcl-2gene.":[593]},"counts_by_year":[],"updated_date":"2026-09-03T10:48:47.769340","created_date":"2016-06-24T00:00:00"}