{"id":"https://openalex.org/W2187446176","doi":null,"title":"Genetics and Epigenetics in Tumorigenesis: Acting Separately or Linked?","display_name":"Genetics and Epigenetics in Tumorigenesis: Acting Separately or Linked?","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2187446176","mag":"2187446176"},"language":"en","primary_location":{"id":"mag:2187446176","doi":null,"is_oa":false,"landing_page_url":"https://austinpublishinggroup.com/clinical-medicine/download.php?file=fulltext/ajcm-v1-id1016.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112120767","display_name":"Zhu X","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhu X","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024245302","display_name":"H Wetta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Wetta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103749478","display_name":"Xuegong Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xuegong Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3304,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.51507233,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":1.0},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.875},{"id":"https://openalex.org/keywords/genetics","display_name":"genetics","score":0.5910000205039978},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.902999997138977},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9909999966621399},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9850000143051147},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9190000295639038},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.890999972820282},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/genetic-epigenetic-interaction","display_name":"genetic-epigenetic interaction","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8806681632995605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7392195463180542},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7254805564880371},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.684698224067688},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6534085869789124},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5028294920921326},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48513516783714294},{"id":"https://openalex.org/C163002167","wikidata":"https://www.wikidata.org/wiki/Q7277124","display_name":"RNA-Directed DNA Methylation","level":5,"score":0.44802531599998474},{"id":"https://openalex.org/C114691636","wikidata":"https://www.wikidata.org/wiki/Q5031434","display_name":"Cancer epigenetics","level":5,"score":0.4437692165374756},{"id":"https://openalex.org/C37080517","wikidata":"https://www.wikidata.org/wiki/Q18353747","display_name":"Epigenetics of physical exercise","level":5,"score":0.42499521374702454},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2699075937271118},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.1850954294204712}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2187446176","doi":null,"is_oa":false,"landing_page_url":"https://austinpublishinggroup.com/clinical-medicine/download.php?file=fulltext/ajcm-v1-id1016.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1499807572","https://openalex.org/W1530676320","https://openalex.org/W1615408253","https://openalex.org/W1994734085","https://openalex.org/W2010625291","https://openalex.org/W2018637944","https://openalex.org/W2029197798","https://openalex.org/W2029484950","https://openalex.org/W2033126020","https://openalex.org/W2052772983","https://openalex.org/W2055205462","https://openalex.org/W2056346153","https://openalex.org/W2058795465","https://openalex.org/W2095803877","https://openalex.org/W2109975638","https://openalex.org/W2111699167","https://openalex.org/W2113171275","https://openalex.org/W2135788727","https://openalex.org/W2137915568","https://openalex.org/W2146143823","https://openalex.org/W2160234594","https://openalex.org/W2160405431"],"related_works":["https://openalex.org/W2582937782","https://openalex.org/W2611465118","https://openalex.org/W2365025341","https://openalex.org/W2123739134","https://openalex.org/W2121618708","https://openalex.org/W1999688639","https://openalex.org/W2097271076","https://openalex.org/W7098815151","https://openalex.org/W1980937575","https://openalex.org/W105341662"],"abstract_inverted_index":{"Tumorigenesis":[0],"represents":[1],"both":[2],"genetic":[3,84],"and":[4,68,85],"epigenetic":[5,42,86],"alterations.":[6],"Genetic":[7],"changes":[8],"are":[9],"defined":[10],"as":[11],"genomic":[12],"DNA":[13,55,60],"sequence":[14],"changes,":[15],"including":[16,28],"point":[17],"mutation,":[18],"single":[19],"nucleotide":[20],"polymorphism":[21],"(SNP)":[22],"or":[23,36],"copy":[24,34],"number":[25,35],"variability":[26],"(CNV),":[27],"loss":[29],"of":[30,48,64,94,102],"heterozygozity":[31],"(LOH),":[32],"gain":[33],"deletion.":[37],"On":[38],"the":[39,53,65,91,100],"other":[40],"hand,":[41],"modification":[43],"is":[44],"responsible":[45],"for":[46],"regulation":[47],"gene":[49,74],"expression":[50],"without":[51],"changing":[52],"underlying":[54],"sequence.":[56],"Such":[57],"mechanisms":[58],"include":[59],"methylation,":[61],"post-translational":[62],"modifications":[63],"histone":[66],"proteins,":[67],"micro":[69],"RNA,":[70],"resulting":[71],"in":[72,77,89],"selective":[73],"activation":[75],"and/or":[76],"activation.":[78],"As":[79],"opposed":[80],"to":[81,97],"solely":[82],"isolated":[83],"components":[87],"acting":[88],"tumorigenesis,":[90],"complex":[92],"nature":[93],"cancer":[95],"seems":[96],"stem":[98],"from":[99],"interaction":[101],"these":[103],"mechanisms.":[104]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}