{"id":"https://openalex.org/W2187428176","doi":null,"title":"Sulphoraphane, by virtue of its antioxidant potential down -regulates HSP90 in leukemia cells","display_name":"Sulphoraphane, by virtue of its antioxidant potential down -regulates HSP90 in leukemia cells","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2187428176","mag":"2187428176"},"language":"en","primary_location":{"id":"mag:2187428176","doi":null,"is_oa":false,"landing_page_url":"https://www.ijcmas.com/vol-3-1/Ruma%20Sarkar,%20et%20al.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072089561","display_name":"Ruma Sarkar","orcid":"https://orcid.org/0000-0002-6450-5185","observed_orcids":["https://orcid.org/0000-0002-6450-5185"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruma Sarkar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6450-5185","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113811937","display_name":"Apurba Kumar Mukherjee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Apurba Mukherjee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022556922","display_name":"Raj Biswas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raj Biswas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103424712","display_name":"Jaydip Biswas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaydip Biswas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5052297426","display_name":"Madhumita Roy","orcid":"https://orcid.org/0000-0002-3551-8534","observed_orcids":["https://orcid.org/0000-0002-3551-8534"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Madhumita Roy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3551-8534","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3304,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.51507233,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.03830000013113022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulforaphane","display_name":"sulforaphane","score":0.7720000147819519},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.871999979019165},{"id":"https://openalex.org/keywords/leukemia-cells","display_name":"leukemia cells","score":0.8009999990463257},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7269999980926514},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.9079999923706055},{"id":"https://openalex.org/keywords/gene-downregulation","display_name":"gene downregulation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cancer-cell-signaling","display_name":"cancer cell signaling","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6293776035308838},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6256284117698669},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6155492663383484},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.48375773429870605},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4596627950668335},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4585743546485901},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43106862902641296},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4246002435684204},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38646039366722107},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3657471239566803},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30641496181488037},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16241440176963806},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1311952769756317}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2187428176","doi":null,"is_oa":false,"landing_page_url":"https://www.ijcmas.com/vol-3-1/Ruma%20Sarkar,%20et%20al.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1973206036","https://openalex.org/W1976788172","https://openalex.org/W1983164501","https://openalex.org/W1985339859","https://openalex.org/W1997238548","https://openalex.org/W1999528345","https://openalex.org/W2000944289","https://openalex.org/W2002308619","https://openalex.org/W2002801265","https://openalex.org/W2004859816","https://openalex.org/W2004886377","https://openalex.org/W2033898136","https://openalex.org/W2035412505","https://openalex.org/W2045215547","https://openalex.org/W2048553024","https://openalex.org/W2050761453","https://openalex.org/W2066799966","https://openalex.org/W2072925339","https://openalex.org/W2094872423","https://openalex.org/W2103392159","https://openalex.org/W2108987359","https://openalex.org/W2111378248","https://openalex.org/W2123583425","https://openalex.org/W2125007784","https://openalex.org/W2132052187","https://openalex.org/W2132702191","https://openalex.org/W2137819605","https://openalex.org/W2140017673","https://openalex.org/W2144332765","https://openalex.org/W2147631083","https://openalex.org/W2157360354","https://openalex.org/W2161696113","https://openalex.org/W2170083866","https://openalex.org/W2172249877","https://openalex.org/W2338314563","https://openalex.org/W2437035782"],"related_works":["https://openalex.org/W2809886836","https://openalex.org/W1443090853","https://openalex.org/W6925672762","https://openalex.org/W7015606370","https://openalex.org/W3153831334","https://openalex.org/W7100359659","https://openalex.org/W1536274572","https://openalex.org/W1974428745","https://openalex.org/W2621333085","https://openalex.org/W7097664386"],"abstract_inverted_index":{"Cancer":[0,28],"cells":[1,29,38],"are":[2,56,111,122],"under":[3],"elevated":[4],"oxidative":[5],"stress,":[6],"which":[7],"is":[8,41],"due":[9,58],"to":[10,59],"an":[11],"imbalance":[12],"between":[13],"cellular":[14],"anti-oxidant":[15,70],"defence":[16],"mechanism":[17],"and":[18,39,76,110],"ROS":[19,34,40,55,84,100,121],"production":[20],"in":[21,89,106],"the":[22,36,45],"cell":[23,107],"(Acharya":[24,117],"et":[25,49,80,97,118],"al.,":[26,50,81,98,119],"2010).":[27,51,120],"produce":[30],"higher":[31],"level":[32,85],"of":[33,63,69,92],"than":[35],"normal":[37],"responsible":[42],"for":[43,113],"maintaining":[44],"cancer":[46,93],"phenotype":[47],"(Gibellini":[48],"In":[52],"tumor":[53],"cells,":[54],"enhanced":[57],"oncogene":[60],"activation,":[61],"lack":[62],"blood":[64],"supply,":[65],"decrease":[66],"or":[67],"inactivation":[68],"enzymes,":[71],"high":[72],"metabolic":[73],"activity":[74],"(Wang":[75],"Yi,":[77],"2008;":[78],"Hole":[79],"2011).":[82,99],"Elevated":[83],"has":[86],"been":[87],"documented":[88],"various":[90],"types":[91],"including":[94],"leukemia":[95],"(Hole":[96],"acts":[101],"as":[102],"a":[103],"secondary":[104],"messenger":[105],"signalling":[108],"cascade":[109],"important":[112],"several":[114],"physiological":[115],"processes":[116],"ISSN:":[123],"2319-7706":[124],"Volume":[125],"3":[126],"Number":[127],"1":[128],"(2014)":[129],"pp.":[130],"476-486":[131],"http://www.ijcmas.com":[132]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}