{"id":"https://openalex.org/W2187397944","doi":null,"title":"Helical Parameters and Correlations of Tandem Leucine Rich Repeats in","display_name":"Helical Parameters and Correlations of Tandem Leucine Rich Repeats in","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2187397944","mag":"2187397944"},"language":"en","primary_location":{"id":"mag:2187397944","doi":null,"is_oa":false,"landing_page_url":"https://www.omicsonline.org/open-access/helical-parameters-of-tandem-leucine-rich-repeats-in-proteins-jpb.1000314.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039016369","display_name":"Hiroki Miyashita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroki Miyashita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109949149","display_name":"Robert H. Kretsinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert H. Kretsinger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036256543","display_name":"Norio Matsushima","orcid":"https://orcid.org/0000-0001-8008-108X","observed_orcids":["https://orcid.org/0000-0001-8008-108X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norio Matsushima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leucine-rich-repeats","display_name":"leucine-rich repeats","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tandem-repeats","display_name":"tandem repeats","score":0.7260000109672546},{"id":"https://openalex.org/keywords/helical-parameters","display_name":"helical parameters","score":0.9449999928474426},{"id":"https://openalex.org/keywords/solenoid","display_name":"solenoid","score":0.5929999947547913},{"id":"https://openalex.org/keywords/repeat-number","display_name":"repeat number","score":0.5580000281333923},{"id":"https://openalex.org/keywords/oligomerization","display_name":"oligomerization","score":0.9359999895095825},{"id":"https://openalex.org/keywords/protein-flexibility","display_name":"protein flexibility","score":0.527999997138977},{"id":"https://openalex.org/keywords/glycosylation","display_name":"glycosylation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C99545290","wikidata":"https://www.wikidata.org/wiki/Q935326","display_name":"Leucine-rich repeat","level":3,"score":0.7675957679748535},{"id":"https://openalex.org/C27149982","wikidata":"https://www.wikidata.org/wiki/Q3456514","display_name":"Tandem repeat","level":4,"score":0.734889030456543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5227223038673401},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4590739905834198},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4441315233707428},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32922154664993286},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2120734453201294},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10665252804756165},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2187397944","doi":null,"is_oa":false,"landing_page_url":"https://www.omicsonline.org/open-access/helical-parameters-of-tandem-leucine-rich-repeats-in-proteins-jpb.1000314.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":153,"referenced_works":["https://openalex.org/W1491610362","https://openalex.org/W1501553911","https://openalex.org/W1515549973","https://openalex.org/W1544092360","https://openalex.org/W1597533137","https://openalex.org/W1884232725","https://openalex.org/W1912320374","https://openalex.org/W1919531331","https://openalex.org/W1964531685","https://openalex.org/W1967506345","https://openalex.org/W1968300035","https://openalex.org/W1969019156","https://openalex.org/W1969971724","https://openalex.org/W1974259023","https://openalex.org/W1974688346","https://openalex.org/W1976581907","https://openalex.org/W1977563493","https://openalex.org/W1978480903","https://openalex.org/W1981045929","https://openalex.org/W1983314723","https://openalex.org/W1990625704","https://openalex.org/W1991001025","https://openalex.org/W1996671942","https://openalex.org/W1998387943","https://openalex.org/W1998446009","https://openalex.org/W2000023984","https://openalex.org/W2000452199","https://openalex.org/W2001141645","https://openalex.org/W2002933908","https://openalex.org/W2003648675","https://openalex.org/W2006061805","https://openalex.org/W2006112136","https://openalex.org/W2007949653","https://openalex.org/W2008042541","https://openalex.org/W2008708467","https://openalex.org/W2010392116","https://openalex.org/W2011152865","https://openalex.org/W2011207394","https://openalex.org/W2012518627","https://openalex.org/W2012847956","https://openalex.org/W2013254847","https://openalex.org/W2014451351","https://openalex.org/W2018731733","https://openalex.org/W2019496511","https://openalex.org/W2024533971","https://openalex.org/W2025637443","https://openalex.org/W2025836873","https://openalex.org/W2026884617","https://openalex.org/W2028627944","https://openalex.org/W2029222627","https://openalex.org/W2030502085","https://openalex.org/W2031861922","https://openalex.org/W2032527122","https://openalex.org/W2033983786","https://openalex.org/W2035132495","https://openalex.org/W2036647205","https://openalex.org/W2036657458","https://openalex.org/W2036659707","https://openalex.org/W2038292458","https://openalex.org/W2038862514","https://openalex.org/W2043934163","https://openalex.org/W2044905338","https://openalex.org/W2047903114","https://openalex.org/W2050527917","https://openalex.org/W2050668337","https://openalex.org/W2052002049","https://openalex.org/W2053352311","https://openalex.org/W2057295978","https://openalex.org/W2059357373","https://openalex.org/W2061091247","https://openalex.org/W2062267695","https://openalex.org/W2062801286","https://openalex.org/W2064419492","https://openalex.org/W2065053912","https://openalex.org/W2066184815","https://openalex.org/W2070118546","https://openalex.org/W2071165179","https://openalex.org/W2073578218","https://openalex.org/W2073764175","https://openalex.org/W2075361277","https://openalex.org/W2075742801","https://openalex.org/W2075917847","https://openalex.org/W2077276598","https://openalex.org/W2081071461","https://openalex.org/W2081110616","https://openalex.org/W2082016203","https://openalex.org/W2082323779","https://openalex.org/W2082570884","https://openalex.org/W2082869269","https://openalex.org/W2083806158","https://openalex.org/W2086928290","https://openalex.org/W2090280616","https://openalex.org/W2092751030","https://openalex.org/W2092757451","https://openalex.org/W2094004923","https://openalex.org/W2094733407","https://openalex.org/W2095545132","https://openalex.org/W2096003791","https://openalex.org/W2098249834","https://openalex.org/W2098845972","https://openalex.org/W2099641930","https://openalex.org/W2101353438","https://openalex.org/W2101365401","https://openalex.org/W2105765197","https://openalex.org/W2106720984","https://openalex.org/W2107158607","https://openalex.org/W2107182434","https://openalex.org/W2110768898","https://openalex.org/W2111396770","https://openalex.org/W2112906863","https://openalex.org/W2114604503","https://openalex.org/W2115850341","https://openalex.org/W2115956404","https://openalex.org/W2116466301","https://openalex.org/W2120818714","https://openalex.org/W2121931871","https://openalex.org/W2122381729","https://openalex.org/W2122483092","https://openalex.org/W2122967721","https://openalex.org/W2123627492","https://openalex.org/W2123687654","https://openalex.org/W2127934565","https://openalex.org/W2130497192","https://openalex.org/W2132428379","https://openalex.org/W2134501763","https://openalex.org/W2134984452","https://openalex.org/W2138349580","https://openalex.org/W2141425494","https://openalex.org/W2141885858","https://openalex.org/W2142320136","https://openalex.org/W2142368344","https://openalex.org/W2145189331","https://openalex.org/W2145567961","https://openalex.org/W2146172133","https://openalex.org/W2146790448","https://openalex.org/W2149281106","https://openalex.org/W2149599741","https://openalex.org/W2150736048","https://openalex.org/W2151440458","https://openalex.org/W2151459176","https://openalex.org/W2152123775","https://openalex.org/W2156475745","https://openalex.org/W2158656883","https://openalex.org/W2158873473","https://openalex.org/W2159398624","https://openalex.org/W2160648204","https://openalex.org/W2160915727","https://openalex.org/W2161577497","https://openalex.org/W2166115538","https://openalex.org/W2167347821","https://openalex.org/W2168933043","https://openalex.org/W2169737891","https://openalex.org/W2321462421"],"related_works":["https://openalex.org/W2321462421","https://openalex.org/W7098684944","https://openalex.org/W3003709823","https://openalex.org/W2044905338","https://openalex.org/W2168933043","https://openalex.org/W3132372476","https://openalex.org/W1984842137","https://openalex.org/W2021853980","https://openalex.org/W4385651854","https://openalex.org/W1662925549"],"abstract_inverted_index":{"Leucine":[0],"rich":[1],"repeats":[2],"(LRRs)":[3],"are":[4,17,57,181],"present":[5],"in":[6,44,59,69,127,174,226],"over":[7],"20,000":[8],"proteins":[9],"from":[10],"viruses":[11],"to":[12,40,46,96,100,222],"eukaryotes.":[13],"Most":[14],"LRR":[15,49,145,179],"units":[16,42,126],"20-30":[18],"residues":[19],"long":[20],"and":[21,30,113,132,205,214,241,247],"can":[22],"be":[23],"divided":[24],"into":[25],"a":[26,31,75,86],"highly":[27,65],"conserved":[28,66],"segment":[29],"variable":[32,183],"segment.":[33],"Eight":[34],"classes":[35,118,146,207],"have":[36,91],"been":[37],"recognized.":[38],"Two":[39],"sixty-two":[41],"occur":[43],"tandem":[45],"form":[47],"an":[48],"structure.":[50],"The":[51,139,230],"tertiary":[52],"structures":[53,105,180],"of":[54,63,74,79,88,103,106,119,124,136,142,162,166,202,212,233],"these":[55,111],"LRRs":[56,102,175,191,235],"helical,":[58],"which":[60],"the":[61,64,122,128,137,143,152,159,163,167,170,178,190,203,223,227,234,253],"\u03b2-strands":[62,157],"segments":[67],"stack":[68],"parallel.":[70],"This":[71,217],"helix":[72],"consists":[73],"super":[76],"helical":[77,98,140,164,231,245,254],"arrangement":[78],"repeating":[80],"structural":[81,228,258],"units.":[82,229],"We":[83,90,109],"call":[84],"it":[85],"coil":[87],"solenoids.":[89],"used":[92],"our":[93],"program":[94],"HELFIT":[95],"assign":[97],"parameters":[99,112,141,165,232,255],"642":[101],"known":[104],"114":[107],"proteins.":[108],"report":[110],"their":[114],"correlations":[115],"with":[116,121,130,133,192],"eight":[117,144],"LRR,":[120,129],"number":[123],"repeat":[125,171,200],"oligomerization,":[131],"ligand":[134],"state":[135],"LRR.":[138],"frequently":[147],"overlap":[148],"one":[149],"another.":[150],"However,":[151],"constant":[153],"distance":[154],"between":[155],"parallel":[156],"is":[158,176,208,219],"primary":[160],"determinant":[161],"LRRs.":[168],"When":[169],"number,":[172],"n,":[173],"small,":[177],"more":[182,187],"and,":[184],"by":[185,261],"inference,":[186],"flexible.":[188],"In":[189],"n":[193],"\u2265":[194],"10,":[195],"\u2206z":[196],"(the":[197],"rise":[198],"per":[199],"unit)":[201],"\u201cRI-like\u201d":[204],"\u201cCysteine-containing\u201d":[206],"smaller":[209],"than":[210],"those":[211],"\u201cSDS22-like\u201d,":[213],"\u201cPlant-specific\u201d":[215],"classes.":[216],"difference":[218],"ascribed":[220],"mainly":[221],"differ":[224],"ence":[225],"unambiguously":[236],"describe":[237],"both":[238],"right":[239],"handed":[240,243],"left":[242],"helices,":[244],"dimers,":[246],"subdomains":[248],"if":[249],"they":[250],"exist.":[251],"Moreover,":[252],"sensitively":[256],"detect":[257],"changes":[259],"induced":[260],"protein,":[262],"protein":[263],"interactions,":[264],"glycosylation,":[265],"and/or":[266],"mutation.":[267]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
