{"id":"https://openalex.org/W2187321809","doi":null,"title":"Efficacy of pyridoxal treatment in controlling the growth of melanomas in cell culture and an animal pilot study.","display_name":"Efficacy of pyridoxal treatment in controlling the growth of melanomas in cell culture and an animal pilot study.","publication_year":1993,"publication_date":"1993-11-01","ids":{"openalex":"https://openalex.org/W2187321809","mag":"2187321809","pmid":"https://pubmed.ncbi.nlm.nih.gov/8297098"},"language":"en","primary_location":{"id":"pmid:8297098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8297098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065330318","display_name":"Andrew B. Maksymowych","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A B Maksymowych","raw_affiliation_strings":["Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107","Jefferson Cancer Institute, Thomas Jefferson University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Jefferson Cancer Institute, Thomas Jefferson University","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108204715","display_name":"Noreen M. Robertson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N M Robertson","raw_affiliation_strings":["Jefferson Cancer Institute, Thomas Jefferson University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jefferson Cancer Institute, Thomas Jefferson University","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062814155","display_name":"Gerald Litwack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Litwack","raw_affiliation_strings":["Jefferson Cancer Institute, Thomas Jefferson University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jefferson Cancer Institute, Thomas Jefferson University","institution_ids":["https://openalex.org/I149251103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I149251103"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.1367467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"13","issue":"6A","first_page":"1925","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.227400004863739,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.227400004863739,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.1979999989271164,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.10480000078678131,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyridoxal","display_name":"pyridoxal","score":0.9990000128746033},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8840000033378601},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.925000011920929},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/triamcinolone-acetonide","display_name":"triamcinolone acetonide","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cortexolone","display_name":"cortexolone","score":0.8399999737739563},{"id":"https://openalex.org/keywords/ru486","display_name":"RU486","score":0.9800000190734863},{"id":"https://openalex.org/keywords/topical-cream","display_name":"topical cream","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.8679999709129333},{"id":"https://openalex.org/keywords/immunocompetent-mice","display_name":"immunocompetent mice","score":0.7319999933242798},{"id":"https://openalex.org/keywords/immunodeficient-mice","display_name":"immunodeficient mice","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C2780859938","wikidata":"https://www.wikidata.org/wiki/Q3065731","display_name":"Pyridoxal","level":3,"score":0.7220152616500854},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6658689975738525},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.544861912727356},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.51014643907547},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5093875527381897},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4612056612968445},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4536823332309723},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4448372423648834},{"id":"https://openalex.org/C2780004078","wikidata":"https://www.wikidata.org/wiki/Q4774743","display_name":"Antiglucocorticoid","level":4,"score":0.4422038793563843},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.4287063181400299},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.36913207173347473},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.36276769638061523},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3610386550426483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34872788190841675},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.33499404788017273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13793706893920898},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003350","descriptor_name":"Cortodoxone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008812","descriptor_name":"Mice, Hairless","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011730","descriptor_name":"Pyridoxal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011730","descriptor_name":"Pyridoxal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011730","descriptor_name":"Pyridoxal","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015735","descriptor_name":"Mifepristone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8297098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8297098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Comparative Study"},{"id":"mag:2187321809","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8297098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4300540132","https://openalex.org/W2020084069","https://openalex.org/W2065241965","https://openalex.org/W2415270613","https://openalex.org/W1985409110","https://openalex.org/W4366183991","https://openalex.org/W7055788589","https://openalex.org/W2113773121","https://openalex.org/W650687727","https://openalex.org/W2409221341"],"abstract_inverted_index":{"We":[0],"have":[1],"demonstrated,":[2],"using":[3,196],"confocal":[4],"laser":[5],"scanning":[6],"microscopy,":[7],"that":[8,200,222],"pyridoxal":[9,39,82,107,127,172,191,229],"treatment":[10,83,183],"of":[11,21,28,81,122,125,136,157,228],"B16C3":[12,41],"murine":[13,42,152],"melanoma":[14,43,48,94,109,139],"cells":[15,44,49,58,110],"inhibits":[16],"triamcinolone":[17],"acetonide":[18],"induced":[19],"translocation":[20],"the":[22,26,68,79,120,131,158,180,209],"glucocorticoid":[23,35,54,69,86],"receptor":[24,36,70],"to":[25,33,65,78,129,178,186,233],"nucleus":[27],"intact":[29],"cells.":[30],"In":[31],"addition":[32],"inhibiting":[34],"nuclear":[37],"translocation,":[38],"kills":[40,57,108],"and":[45,146,185,211],"WM983A":[46],"human":[47],"in":[50,59,67,98,111,141,192,216],"culture.":[51,60],"Cortexolone,":[52],"a":[53,75,113,126],"antagonist,":[55],"also":[56],"This":[61],"mechanism,":[62],"however,":[63,97],"appears":[64],"initiate":[66],"signal":[71],"transducing":[72],"cascade":[73],"at":[74],"point":[76],"prior":[77],"impact":[80],"alone.":[84],"The":[85,155],"antagonist":[87],"RU486":[88,102],"has":[89],"no":[90],"detrimental":[91],"effect":[92],"on":[93],"cell":[95,104],"viability,":[96],"combination":[99],"with":[100,160],"pyridoxal,":[101],"extends":[103],"viability.":[105],"Since":[106],"culture,":[112],"pilot":[114],"study":[115,159],"was":[116],"carried":[117],"out":[118],"examining":[119],"efficacy":[121],"topical":[123,193],"application":[124],"cream":[128],"inhibit":[130],"growth":[132,215],"and/or":[133],"cause":[134],"regression":[135],"(B16C3)":[137],"xenograft":[138],"tumors":[140,166],"an":[142,147],"immunocompetent":[143,161],"(Hairless":[144],"Rhino-J3)":[145],"immunocompromised":[148,197],"(Crl:":[149],"nu/nu":[150],"(CD1)BR)":[151],"animal":[153],"model.":[154],"results":[156],"animals":[162,198,218],"are":[163,167],"encouraging.":[164],"While":[165],"brought":[168],"under":[169],"control":[170,210],"by":[171],"treatment,":[173],"further":[174],"work":[175],"is":[176,219],"needed":[177,232],"determine":[179],"most":[181],"efficacious":[182],"regimen":[184],"establish":[187],"formal":[188],"concentrations":[189,227],"for":[190],"ointments.":[194],"Trials":[195],"indicated":[199],"although":[201],"some":[202],"qualitative":[203],"differences":[204],"may":[205,230],"be":[206,231],"detected":[207],"between":[208],"experimental":[212],"animals,":[213],"tumor":[214],"these":[217],"so":[220],"aggressive":[221],"multiple":[223],"applications":[224],"or":[225],"higher":[226],"obtain":[234],"useful":[235],"data.":[236]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
