{"id":"https://openalex.org/W2187253138","doi":null,"title":"PHOSPHO-TAU (181P) assay for discrimination between Alzheimer's disease and dementia with Lewy bodies","display_name":"PHOSPHO-TAU (181P) assay for discrimination between Alzheimer's disease and dementia with Lewy bodies","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2187253138","mag":"2187253138"},"language":"en","primary_location":{"id":"mag:2187253138","doi":null,"is_oa":false,"landing_page_url":"http://epub.ub.uni-muenchen.de/17797/1/cclm.2006.258.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050302864","display_name":"Hugo Vanderstichele","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hugo Vanderstichele","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109943428","display_name":"Karen de Vreese","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K De Vreese","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025313057","display_name":"Kaj Blennow","orcid":"https://orcid.org/0000-0002-1890-4193","observed_orcids":["https://orcid.org/0000-0002-1890-4193"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaj Blennow","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1890-4193","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107073671","display_name":"Niels Andreasen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Niels Andreasen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024150878","display_name":"Adrian Ivanoiu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adrian Ivanoiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037109052","display_name":"Harald Juergen Hampel","orcid":"https://orcid.org/0000-0003-0894-8982","observed_orcids":["https://orcid.org/0000-0003-0894-8982"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harald Hampel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0894-8982","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019846852","display_name":"Lucilla Parnetti","orcid":"https://orcid.org/0000-0001-5722-3967","observed_orcids":["https://orcid.org/0000-0001-5722-3967"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucilla Parnetti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5722-3967","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089967868","display_name":"Alessandro Padovani","orcid":"https://orcid.org/0000-0002-0119-3639","observed_orcids":["https://orcid.org/0000-0002-0119-3639"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allesandro Padovani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084526485","display_name":"Hans Pottel","orcid":"https://orcid.org/0000-0003-0074-8919","observed_orcids":["https://orcid.org/0000-0003-0074-8919"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans Pottel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0074-8919","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071088060","display_name":"Frank Hulstaert","orcid":"https://orcid.org/0000-0003-2879-9910","observed_orcids":["https://orcid.org/0000-0003-2879-9910"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Hulstaert","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2879-9910","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5077992405","display_name":"Eugeen Vanmechelen","orcid":"https://orcid.org/0000-0002-9466-5366","observed_orcids":["https://orcid.org/0000-0002-9466-5366"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eugeen Vanmechelen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9466-5366","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8065999746322632,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8065999746322632,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.1891999989748001,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.843999981880188},{"id":"https://openalex.org/keywords/dementia-with-lewy-bodies","display_name":"dementia with Lewy bodies","score":1.0},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.9509999752044678},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/total-tau","display_name":"total tau","score":0.7480000257492065},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.9309999942779541},{"id":"https://openalex.org/keywords/assay-validation","display_name":"assay validation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C2778548049","wikidata":"https://www.wikidata.org/wiki/Q101245788","display_name":"Dementia with Lewy bodies","level":4,"score":0.8862931728363037},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5804098844528198},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5105503797531128},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.498032808303833},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.4701939523220062},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4386093020439148},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4380713999271393},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.37942150235176086},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.372484028339386},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34316933155059814}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2187253138","doi":null,"is_oa":false,"landing_page_url":"http://epub.ub.uni-muenchen.de/17797/1/cclm.2006.258.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1545447974","https://openalex.org/W1600934558","https://openalex.org/W1847168837","https://openalex.org/W1958842451","https://openalex.org/W1971647405","https://openalex.org/W1986423432","https://openalex.org/W1988967522","https://openalex.org/W2010584905","https://openalex.org/W2019253788","https://openalex.org/W2035680108","https://openalex.org/W2057236704","https://openalex.org/W2060546506","https://openalex.org/W2069277654","https://openalex.org/W2075234278","https://openalex.org/W2079540265","https://openalex.org/W2087097612","https://openalex.org/W2099570666","https://openalex.org/W2103304217","https://openalex.org/W2104037550","https://openalex.org/W2108475007","https://openalex.org/W2123056519","https://openalex.org/W2126102871","https://openalex.org/W2150246483","https://openalex.org/W2155784539","https://openalex.org/W2156220037","https://openalex.org/W2159377066","https://openalex.org/W2169881190"],"related_works":["https://openalex.org/W2009206406","https://openalex.org/W1987397445","https://openalex.org/W2068977979","https://openalex.org/W1597472338","https://openalex.org/W2075234278","https://openalex.org/W7095792114","https://openalex.org/W2779090742","https://openalex.org/W2150246483","https://openalex.org/W4205420989","https://openalex.org/W62560881"],"abstract_inverted_index":{"Background:":[0],"Total":[1],"tau":[2,100],"(T-tau)":[3],"and":[4,57,69,115,123,144,152],"b-amyloid(1-42)":[5],"(Ab1-42)":[6],"levels":[7],"in":[8,32,49,92,106,113,159],"cerebrospinal":[9],"fluid":[10],"(CSF)":[11],"can":[12],"differ-":[13],"entiate":[14],"Alzheimer's":[15],"disease":[16],"(AD)":[17],"from":[18,26,77,80,84,162],"normal":[19],"aging":[20],"or":[21,65,83],"depressive":[22],"pseudo-dementia.":[23],"Differential":[24],"diagnosis":[25],"dementia":[27],"with":[28,67],"Lewy":[29],"bodies":[30],"(DLB)":[31],"clinical":[33],"set-":[34],"tings":[35],"is":[36,149],"difficult.":[37],"Methods:":[38],"The":[39],"analytical":[40],"performance":[41],"of":[42,51,61,74,99,136],"the":[43,62,130,137],"INNO-":[44],"TESTPHOSPHO-TAU(181P)":[45],"assay":[46,63,154],"was":[47,90,108,129],"validated":[48],"terms":[50],"selectivity,":[52],"sensitivity,":[53],"specificity,":[54],"precision,":[55],"robustness,":[56],"stability.":[58],"Clinical":[59],"utility":[60],"alone,":[64],"combined":[66],"T-tau":[68],"Ab1-42,":[70],"for":[71,140],"discrim-":[72],"ination":[73],"AD":[75,107,143,161],"(ns94)":[76],"patients":[78],"suffering":[79],"DLB":[81,114],"(ns60)":[82,89],"age-matched":[85],"control":[86],"subjects":[87],"(CS)":[88],"assessed":[91],"a":[93,119,150],"multicenter":[94],"study.":[95],"Results:":[96],"CSF":[97],"concentrations":[98],"phosphorylated":[101],"at":[102],"threonine":[103],"181":[104],"(P-tau181P)":[105],"significantly":[109],"high-":[110],"er":[111],"than":[112],"CS.":[116],"Discriminant":[117],"analysis,":[118],"clas-":[120],"sification":[121],"tree,":[122],"logistic":[124],"regression":[125],"showed":[126],"that":[127,155],"P-tau181P":[128,147],"most":[131],"statistically":[132],"significant":[133],"single":[134],"variable":[135],"three":[138],"biomarkers":[139],"discrimination":[141],"between":[142],"DLB.":[145,163],"Conclusions:":[146],"quantification":[148],"robust":[151],"reliable":[153],"may":[156],"be":[157],"useful":[158],"discriminating":[160],"Clin":[164],"Chem":[165],"Lab":[166],"Med":[167],"2006;44:1472-80.":[168]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
