{"id":"https://openalex.org/W2187221209","doi":null,"title":"11. Application to Danish HLA A and B Locus Data","display_name":"11. Application to Danish HLA A and B Locus Data","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2187221209","mag":"2187221209"},"language":"en","primary_location":{"id":"mag:2187221209","doi":null,"is_oa":false,"landing_page_url":"https://www.genetics.org/content/116/4/633.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081541099","display_name":"William Klitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William Klitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111566218","display_name":"Glenys J. Thomson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glenys Thomson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1705175,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.5853999853134155,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.5853999853134155,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.22990000247955322,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.11029999703168869,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.9350000023841858},{"id":"https://openalex.org/keywords/haplotype-selection","display_name":"haplotype selection","score":0.6650000214576721},{"id":"https://openalex.org/keywords/hla-haplotypes","display_name":"HLA haplotypes","score":0.7459999918937683},{"id":"https://openalex.org/keywords/population-admixture","display_name":"population admixture","score":0.5929999947547913},{"id":"https://openalex.org/keywords/genetic-drift","display_name":"genetic drift","score":0.906000018119812},{"id":"https://openalex.org/keywords/evolutionary-selection","display_name":"evolutionary selection","score":0.3709999918937683},{"id":"https://openalex.org/keywords/danish-population","display_name":"Danish population","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.8703621625900269},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.826370120048523},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.7271816730499268},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.644463300704956},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6195301413536072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5981210470199585},{"id":"https://openalex.org/C2778146401","wikidata":"https://www.wikidata.org/wiki/Q10916362","display_name":"Disequilibrium","level":2,"score":0.5158112049102783},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.48714134097099304},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4816126227378845},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4544317424297333},{"id":"https://openalex.org/C164622146","wikidata":"https://www.wikidata.org/wiki/Q9035","display_name":"Danish","level":2,"score":0.4438219368457794},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.3269268870353699},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10213238000869751},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.09851518273353577},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.08253851532936096},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.08025693893432617},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.06009426712989807},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2187221209","doi":null,"is_oa":false,"landing_page_url":"https://www.genetics.org/content/116/4/633.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W131236983","https://openalex.org/W163811349","https://openalex.org/W438523755","https://openalex.org/W1408645568","https://openalex.org/W1900840194","https://openalex.org/W1965380581","https://openalex.org/W2011275780","https://openalex.org/W2019892260","https://openalex.org/W2032510327","https://openalex.org/W2072706575","https://openalex.org/W2161827142","https://openalex.org/W2163115265","https://openalex.org/W2166784471","https://openalex.org/W2401191574","https://openalex.org/W2410078417","https://openalex.org/W2463122580"],"related_works":["https://openalex.org/W1856944297","https://openalex.org/W2117908893","https://openalex.org/W2498309396","https://openalex.org/W2463122580","https://openalex.org/W1900840194","https://openalex.org/W2021051684","https://openalex.org/W2140837573","https://openalex.org/W2124106036","https://openalex.org/W2067757939","https://openalex.org/W2071493505"],"abstract_inverted_index":{"Disequilibrium":[0],"pattern":[1],"analysis,":[2],"a":[3,21],"general":[4],"method":[5],"for":[6,28],"analyzing":[7],"evolutionary":[8],"events":[9],"acting":[10],"on":[11,43],"pairs":[12],"of":[13,24,33,41,50,73,77],"tightly":[14],"linked":[15],"polymorphic":[16],"loci,":[17],"is":[18],"applied":[19],"to":[20],"large":[22],"sample":[23],"Danish":[25],"individuals":[26],"typed":[27],"A":[29],"and":[30],"B":[31],"loci":[32],"the":[34,54,74,88],"HLA":[35,55],"(human":[36],"leukocyte":[37],"antigen)":[38],"system.":[39],"Cases":[40],"selection":[42],"particular":[44],"haplotypes":[45,71,79],"are":[46],"revealed":[47],"from":[48],"patterns":[49,58,89],"linkage":[51],"disequilibrium":[52],"among":[53],"haplotypes.":[56],"These":[57],"cannot":[59],"be":[60],"explained":[61],"by":[62],"either":[63],"population":[64],"admixture":[65],"or":[66],"random":[67],"genetic":[68],"drift.":[69],"Six":[70],"out":[72],"total":[75],"array":[76],"273":[78],"have":[80],"been":[81],"identified":[82],"which":[83],"show":[84],"in":[85],"varying":[86],"extents":[87],"indicating":[90],"selection.":[91]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}