{"id":"https://openalex.org/W2187196174","doi":null,"title":"Tubuloglomerular feedback in one-kidney, one-clip hypertensive rats.","display_name":"Tubuloglomerular feedback in one-kidney, one-clip hypertensive rats.","publication_year":1991,"publication_date":"1991-06-01","ids":{"openalex":"https://openalex.org/W2187196174","mag":"2187196174","pmid":"https://pubmed.ncbi.nlm.nih.gov/1881033"},"language":"en","primary_location":{"id":"pmid:1881033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1881033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international. Supplement","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030109930","display_name":"Ploth Dw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D W Ploth","raw_affiliation_strings":["Division of Nephrology, Medical of South Carolina, Charleston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Medical of South Carolina, Charleston","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113772170","display_name":"Mackenzie Hs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H S Mackenzie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.1691905,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"32","issue":null,"first_page":"S115","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies","score":0.3788999915122986,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies","score":0.3788999915122986,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.3359000086784363,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.2467000037431717,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tubuloglomerular-feedback","display_name":"tubuloglomerular feedback","score":1.0},{"id":"https://openalex.org/keywords/one-kidney-one-clip-hypertension","display_name":"one-kidney one-clip hypertension","score":0.9229999780654907},{"id":"https://openalex.org/keywords/renal-autoregulation","display_name":"renal autoregulation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.9819999933242798},{"id":"https://openalex.org/keywords/stop-flow-pressure","display_name":"stop-flow pressure","score":0.871999979019165},{"id":"https://openalex.org/keywords/proximal-tubule","display_name":"proximal tubule","score":0.8330000042915344},{"id":"https://openalex.org/keywords/captopril","display_name":"captopril","score":0.8309999704360962},{"id":"https://openalex.org/keywords/acute-renal-dysfunction","display_name":"acute renal dysfunction","score":0.7870000004768372},{"id":"https://openalex.org/keywords/unilateral-nephrectomy","display_name":"unilateral nephrectomy","score":0.7799999713897705},{"id":"https://openalex.org/keywords/renal-artery-stenosis","display_name":"renal artery stenosis","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C7643261","wikidata":"https://www.wikidata.org/wiki/Q3742013","display_name":"Tubuloglomerular feedback","level":3,"score":0.8328683376312256},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.751838207244873},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6772603988647461},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6566818952560425},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5960334539413452},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.558570146560669},{"id":"https://openalex.org/C111774379","wikidata":"https://www.wikidata.org/wiki/Q1364253","display_name":"Autoregulation","level":3,"score":0.5252596735954285},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5116541981697083},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5067864060401917},{"id":"https://openalex.org/C2780222010","wikidata":"https://www.wikidata.org/wiki/Q2916078","display_name":"Proximal tubule","level":3,"score":0.4359205365180969},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38796454668045044}],"mesh":[{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002216","descriptor_name":"Captopril","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006978","descriptor_name":"Hypertension, Renovascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007684","descriptor_name":"Kidney Tubules","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1881033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1881033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international. Supplement","raw_type":"Journal Article"},{"id":"mag:2187196174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1881033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2408976793","https://openalex.org/W2020636634","https://openalex.org/W1992537324","https://openalex.org/W2295073168","https://openalex.org/W2022182040","https://openalex.org/W1979661565","https://openalex.org/W1819343816","https://openalex.org/W2031317456","https://openalex.org/W2085591802","https://openalex.org/W2414349158"],"abstract_inverted_index":{"Previous":[0],"studies":[1,266],"have":[2],"shown":[3],"that":[4,172,228],"hydropenic":[5],"one-kidney,":[6],"one-clip":[7],"(1-K,":[8],"1-C)":[9],"hypertensive":[10],"HT":[11,65,129,184,202,237],"rats":[12,44,66,185,203,238],"exhibit":[13],"impaired":[14,178],"autoregulation":[15,179],"of":[16,33,123,142,161,180,220,255,260],"glomerular":[17],"filtration":[18],"rate":[19],"(GFR)":[20],"in":[21,39,63,68,78,84,113,116,127,135,150,182,186,207,214,231,234,244,250,278],"response":[22,85,187,194,251],"to":[23,86,91,177,188,195,226,252,270],"reduced":[24,189],"arterial":[25,209],"perfusion":[26,102,148,159,191],"pressure.":[27,192],"We":[28],"investigated":[29],"the":[30,57,100,136,170,200,235,245,272],"possible":[31],"role":[32,243,274],"altered":[34,173],"tubuloglomerular":[35],"feedback":[36],"(TGF)":[37],"activity":[38,73,126,175],"this":[40],"phenomenon.":[41],"Uninephrectomized":[42],"Wistar":[43],"were":[45,61,133,144,156],"studied":[46],"acutely":[47],"3":[48],"weeks":[49],"after":[50],"placing":[51],"silver":[52],"clips":[53],"(0.2":[54],"mm)":[55],"on":[56],"renal":[58,190,247],"artery.":[59],"Experiments":[60],"performed":[62],"1-K,1-C":[64,128,183,201,236],"and":[67,153,216],"uninephrectomized":[69,137],"control":[70],"animals.":[71,138],"TGF":[72,125,174,221,232],"was":[74],"assessed":[75],"as":[76],"changes":[77,141],"proximal":[79,96,109],"tubule":[80,97,110],"stop-flow":[81],"pressure":[82,210,257],"(SFP)":[83],"orthograde":[87],"microperfusion":[88],"from":[89],"0":[90],"80":[92],"nl/min":[93],"into":[94,107],"late":[95,108],"segments.":[98],"Only":[99],"highest":[101],"rates":[103,149,160],"(approximately":[104],"40":[105],"nl/min)":[106],"segments":[111],"resulted":[112],"maximal":[114,154],"decreases":[115,206,213,254],"SFP,":[117],"indicating":[118],"a":[119,240],"marked":[120,205],"rightward":[121],"shift":[122],"overall":[124],"rats.":[130],"Similar":[131],"responses":[132,155],"observed":[134,145,157,249],"In":[139,193],"contrast,":[140],"SFP":[143,215],"at":[146,158],"lower":[147],"normal":[151],"animals":[152],"approximately":[162],"20":[163],"nl/min.":[164],"These":[165],"observations":[166],"are":[167],"consistent":[168],"with":[169,197,212],"possibility":[171],"contributes":[176],"GFR":[181],"treatment":[196],"i.v.":[198],"captopril,":[199],"exhibited":[204],"systemic":[208],"associated":[211],"virtually":[217],"complete":[218],"inhibition":[219],"activity.":[222,263],"It":[223],"is":[224],"attractive":[225],"hypothesize":[227],"these":[229,279],"alterations":[230],"characteristics":[233],"play":[239],"significant":[241],"pathophysiologic":[242],"acute":[246,253],"dysfunction":[248],"blood":[256],"during":[258],"conditions":[259],"augmented":[261],"angiotensin":[262,277],"Additional":[264],"future":[265],"will":[267],"allow":[268],"us":[269],"address":[271],"precise":[273],"for":[275],"intrarenal":[276],"phenomena.":[280]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}