{"id":"https://openalex.org/W2187044277","doi":null,"title":"The effect of high frequency stimulation on intracellular Ca 2+ in sympathetic PC12 cells","display_name":"The effect of high frequency stimulation on intracellular Ca 2+ in sympathetic PC12 cells","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2187044277","mag":"2187044277"},"language":"en","primary_location":{"id":"mag:2187044277","doi":null,"is_oa":false,"landing_page_url":"http://www.lifesciencesite.com/lsj/life0602/14life0602_65_70woyan.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100520797","display_name":"Yan Wo","orcid":"https://orcid.org/0000-0002-9076-1801","observed_orcids":["https://orcid.org/0000-0002-9076-1801"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Wo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Rong Xia","orcid":"https://orcid.org/0000-0001-8573-2152","observed_orcids":["https://orcid.org/0000-0001-8573-2152"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rong Xia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8573-2152","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100448892","display_name":"Feng Li","orcid":"https://orcid.org/0000-0002-3768-3816","observed_orcids":["https://orcid.org/0000-0002-3768-3816"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feng Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3768-3816","affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Wenlong Ding","orcid":"https://orcid.org/0000-0003-3669-3905","observed_orcids":["https://orcid.org/0000-0003-3669-3905"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenlong Ding","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3669-3905","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.4284999966621399,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.4284999966621399,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.26249998807907104,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.05829999968409538,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-frequency-stimulation","display_name":"high-frequency stimulation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.9860000014305115},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/sympathetic-neurons","display_name":"sympathetic neurons","score":0.9419999718666077},{"id":"https://openalex.org/keywords/nifedipine","display_name":"nifedipine","score":0.9580000042915344},{"id":"https://openalex.org/keywords/calcium-channel-blockade","display_name":"calcium channel blockade","score":0.75},{"id":"https://openalex.org/keywords/calcium-fluorescence","display_name":"calcium fluorescence","score":0.7269999980926514},{"id":"https://openalex.org/keywords/line-scanning","display_name":"line scanning","score":0.3880000114440918},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C2779066535","wikidata":"https://www.wikidata.org/wiki/Q39111","display_name":"Nifedipine","level":3,"score":0.7201957106590271},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.562584638595581},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.525029718875885},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5220320224761963},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.47904765605926514},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.4192524552345276},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3999054729938507},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38757985830307007},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.37618932127952576},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35874855518341064},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.2543463706970215},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24141186475753784},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.156520813703537},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.1508888304233551},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13792458176612854},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1198779046535492},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.10243552923202515}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2187044277","doi":null,"is_oa":false,"landing_page_url":"http://www.lifesciencesite.com/lsj/life0602/14life0602_65_70woyan.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1597919750","https://openalex.org/W1599646613","https://openalex.org/W1963622643","https://openalex.org/W1970587959","https://openalex.org/W1975393965","https://openalex.org/W1990139370","https://openalex.org/W1993822995","https://openalex.org/W2000631088","https://openalex.org/W2002898823","https://openalex.org/W2005821801","https://openalex.org/W2008712137","https://openalex.org/W2026420920","https://openalex.org/W2027240586","https://openalex.org/W2030708851","https://openalex.org/W2032466814","https://openalex.org/W2058973689","https://openalex.org/W2110822707","https://openalex.org/W2113151837","https://openalex.org/W2163594997","https://openalex.org/W2169815799"],"related_works":["https://openalex.org/W2208230172","https://openalex.org/W2008712137","https://openalex.org/W7097996870","https://openalex.org/W2052059895","https://openalex.org/W2293051651","https://openalex.org/W2324776193","https://openalex.org/W2117906917","https://openalex.org/W2080579156","https://openalex.org/W2350725321","https://openalex.org/W2082172925"],"abstract_inverted_index":{"Objective.":[0],"This":[1,146],"study":[2],"were":[3,42],"designed":[4],"to":[5,30],"compare":[6],"the":[7,20,32,78,107,112,162,203],"impact":[8],"of":[9,34,87,92,114,164,206,212],"instant":[10,49,181],"high":[11],"frequency":[12],"stimulation":[13],"(HFS)":[14],"and":[15,29,51,89,111,189],"3-day":[16,52,193],"continuous":[17,53,194],"HFS":[18,50,88,105,122,170,195,207],"on":[19,106,175,208],"intracellular":[21,79,96],"Ca":[22,80,97,136,151,165,183],"2+":[23,81,98,137,152,166,184],"volume":[24,167],"in":[25,36],"sympathetic":[26,108,176],"PC12":[27,109,177,209],"cells":[28,41,110],"define":[31],"role":[33],"Nifedipine(NIF)":[35],"this":[37],"process.":[38],"Methods.":[39],"The":[40,95],"randomly":[43],"divided":[44],"into":[45],"two":[46],"groups,":[47],"namely":[48],"HFS.":[54,93],"Using":[55],"a":[56,61,143,172],"line":[57,118],"scanning":[58,119],"technique":[59],"under":[60],"Laser":[62],"Scanning":[63],"Microscope":[64],"(LSM)":[65],"at":[66],"1.2":[67],"ms":[68,71],"\u2013":[69,221,225],"1.25":[70],"intervals":[72],"for":[73,126],"60s,":[74],"we":[75],"found":[76],"that":[77,161],"fluorescence":[82,99,138,185],"intensity":[83,100,139,186],"changes":[84],"between":[85],"conduction":[86],"after":[90,104,192],"termination":[91],"Results.":[94],"rapidly":[101],"declined":[102],"instantly":[103],"range":[113],"declination":[115],"observed":[116],"through":[117,169],"was":[120,123,148,196],"47.7%.":[121],"conducted":[124],"continuously":[125],"3":[127,129],"days,":[128],"hours":[130],"per":[131],"day.":[132],"After":[133],"discontinuing":[134],"HFS,":[135,182],"increased":[140,187],"sharply":[141,191],"with":[142],"60%":[144],"inclination.":[145],"effect":[147,174,205],"weakened":[149],"by":[150],"channel":[153],"inhibitor":[154],"Nifedipine":[155],"(NIF).":[156],"Conclusion.":[157],"These":[158],"data":[159],"indicates":[160],"variation":[163],"induced":[168],"has":[171],"significant":[173],"cells.":[178],"On":[179],"commencing":[180],"significantly":[188],"decreased":[190],"terminated.":[197],"However,":[198],"NIF":[199],"can":[200],"partially":[201],"counteract":[202],"inhibitory":[204],"cells,":[210],"instead":[211],"complete":[213],"blockage.":[214],"[Life":[215],"Science":[216],"Journal.":[217],"2009;":[218],"6(2):":[219],"65":[220],"70]":[222],"(ISSN:":[223],"1097":[224],"8135).":[226]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
