{"id":"https://openalex.org/W2187002009","doi":null,"title":"The neuroprotective effects of grape seed proanthocyanidin on rat brain injury caused by chronic intermittent hypoxia","display_name":"The neuroprotective effects of grape seed proanthocyanidin on rat brain injury caused by chronic intermittent hypoxia","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2187002009","mag":"2187002009"},"language":"en","primary_location":{"id":"mag:2187002009","doi":null,"is_oa":false,"landing_page_url":"http://neurologyasia.org/articles/neuroasia-2014-19(4)-399.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025866007","display_name":"Yaning Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ya-Ning Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028997510","display_name":"Xia Nan Guo","orcid":"https://orcid.org/0000-0002-9283-3274","observed_orcids":["https://orcid.org/0000-0002-9283-3274"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xia Guo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9283-3274","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Hongyang Wang","orcid":"https://orcid.org/0000-0002-4709-3334","observed_orcids":["https://orcid.org/0000-0002-4709-3334"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hongyang Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4709-3334","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100412924","display_name":"Lin Li","orcid":"https://orcid.org/0000-0002-9996-9377","observed_orcids":["https://orcid.org/0000-0002-9996-9377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9996-9377","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100411733","display_name":"Panpan Zhang","orcid":"https://orcid.org/0000-0002-8211-5930","observed_orcids":["https://orcid.org/0000-0002-8211-5930"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Panpan Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8211-5930","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020598016","display_name":"Xiaoqing","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoqing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Wen-Qian Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-Qian Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8495,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.71219094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.08030000329017639,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.03799999877810478,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grape-seed-proanthocyanidins","display_name":"grape seed proanthocyanidins","score":0.9580000042915344},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8740000128746033},{"id":"https://openalex.org/keywords/chronic-intermittent-hypoxia","display_name":"chronic intermittent hypoxia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sleep-disordered-breathing","display_name":"sleep-disordered breathing","score":0.796999990940094},{"id":"https://openalex.org/keywords/brain-injury","display_name":"brain injury","score":0.8450000286102295},{"id":"https://openalex.org/keywords/mitochondrial-ultrastructure","display_name":"mitochondrial ultrastructure","score":0.5130000114440918},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9390000104904175},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9480000138282776},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":1.0},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/learning-disabilities","display_name":"learning disabilities","score":0.7059999704360962},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C77784730","wikidata":"https://www.wikidata.org/wiki/Q415265","display_name":"Proanthocyanidin","level":4,"score":0.6928390860557556},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6760981678962708},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.6666133403778076},{"id":"https://openalex.org/C2780796939","wikidata":"https://www.wikidata.org/wiki/Q25326656","display_name":"Intermittent hypoxia","level":3,"score":0.6452814340591431},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.623619556427002},{"id":"https://openalex.org/C2776971262","wikidata":"https://www.wikidata.org/wiki/Q5597007","display_name":"Grape seed extract","level":3,"score":0.5954527854919434},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.5730410814285278},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.5156489610671997},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.476591557264328},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4600948691368103},{"id":"https://openalex.org/C2781458332","wikidata":"https://www.wikidata.org/wiki/Q720026","display_name":"Brain damage","level":2,"score":0.43220990896224976},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38533490896224976},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3703468143939972},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3563007712364197},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3509625792503357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34584149718284607},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3451637029647827},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.2859499454498291},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23675432801246643},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.22634929418563843},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.190615713596344},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.1383853256702423},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.09138563275337219},{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.05373448133468628},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2187002009","doi":null,"is_oa":false,"landing_page_url":"http://neurologyasia.org/articles/neuroasia-2014-19(4)-399.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W4081360","https://openalex.org/W180875623","https://openalex.org/W1551704442","https://openalex.org/W2009154394","https://openalex.org/W2015107929","https://openalex.org/W2030447619","https://openalex.org/W2036973600","https://openalex.org/W2042533342","https://openalex.org/W2066461919","https://openalex.org/W2077516224","https://openalex.org/W2086657362","https://openalex.org/W2087527499","https://openalex.org/W2090894363","https://openalex.org/W2097273693","https://openalex.org/W2107419196","https://openalex.org/W2124109702","https://openalex.org/W2147199764","https://openalex.org/W2162688500"],"related_works":["https://openalex.org/W2367133955","https://openalex.org/W3030137129","https://openalex.org/W2947802143","https://openalex.org/W2944393322","https://openalex.org/W2036509452","https://openalex.org/W2381518295","https://openalex.org/W4412596799","https://openalex.org/W2359375082","https://openalex.org/W296809411","https://openalex.org/W1973398504"],"abstract_inverted_index":{"Chronic":[0],"intermitted":[1],"hypoxia":[2,32,68,148],"including":[3],"sleep":[4,150],"breathing":[5,151],"disorder":[6],"leads":[7],"to":[8,115],"brain":[9,144],"injury.":[10],"This":[11],"study":[12],"explores":[13],"the":[14,36,52,54,58,107,132,143],"potential":[15],"therapeutic":[16],"effects":[17],"of":[18,29,44,120],"grape":[19,45,121,138],"seed":[20,46,122,139],"proanthocyanidin":[21,123,140],"as":[22],"a":[23],"neuroprotective":[24],"agent.":[25],"A":[26],"rat":[27],"model":[28],"chronic":[30],"intermittent":[31],"was":[33],"employed,":[34],"and":[35,57,82,130],"animals":[37,108],"were":[38,61],"given":[39],"low":[40],"or":[41],"high":[42],"doses":[43],"proanthocyanidin.":[47],"The":[48,63,118],"ultrastructure":[49],"changes":[50],"in":[51,101],"brain,":[53],"biochemical":[55],"components,":[56],"animal":[59],"behavior":[60],"examined.":[62],"results":[64],"showed":[65,109],"that":[66,137],"with":[67,77],"exposure,":[69],"neuronal":[70],"mitochondria":[71],"exhibited":[72],"injuries":[73],"at":[74],"ultrastructural":[75],"level,":[76],"increased":[78,98],"malondialdehyde":[79],"(MDA)":[80],"content":[81],"reduced":[83],"superoxide":[84],"dismutase":[85],"(SOD)":[86],"activity.":[87],"Terminal":[88],"deoxynucleotidyl":[89],"transferase":[90],"dUTP":[91],"nick":[92],"end":[93],"labeling":[94],"(TUNEL)":[95],"staining":[96],"revealed":[97],"cell":[99],"apoptosis":[100],"hippocampus.":[102],"In":[103],"Morris":[104],"water":[105],"maze":[106],"decreased":[110],"learning":[111,133],"abilities,":[112],"when":[113],"compared":[114],"normal":[116],"control.":[117],"administration":[119],"treatment":[124],"reversed":[125],"all":[126],"these":[127],"observed":[128],"changes,":[129],"improved":[131],"behavior.":[134],"We":[135],"concluded":[136],"could":[141],"alleviate":[142],"injury":[145],"caused":[146],"by":[147],"from":[149],"disorder.":[152]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}