{"id":"https://openalex.org/W2186972201","doi":null,"title":"Bilirubin effect on endothelial adhesion molecules expression is mediated by the NF-kappaB signaling pathway.","display_name":"Bilirubin effect on endothelial adhesion molecules expression is mediated by the NF-kappaB signaling pathway.","publication_year":2009,"publication_date":"2009-08-01","ids":{"openalex":"https://openalex.org/W2186972201","mag":"2186972201","pmid":"https://pubmed.ncbi.nlm.nih.gov/20103840"},"language":"en","primary_location":{"id":"pmid:20103840","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20103840","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience trends","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008042811","display_name":"Graciela L. Mazzone","orcid":"https://orcid.org/0000-0003-3360-9931","observed_orcids":["https://orcid.org/0000-0003-3360-9931"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Graciela Luj\u00e1n Mazzone","raw_affiliation_strings":["Centro Studi Fegato, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Studi Fegato, Trieste, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053095105","display_name":"Igino Rigato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Igino Rigato","raw_affiliation_strings":["University of Trieste,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Trieste,","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020748511","display_name":"J. Donald Ostrow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Donald Ostrow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5071646464","display_name":"Claudio Tiribelli","orcid":"https://orcid.org/0000-0001-6596-7595","observed_orcids":["https://orcid.org/0000-0001-6596-7595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudio Tiribelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6593,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.65165831,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"3","issue":"4","first_page":"151","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.6464999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.6464999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.14159999787807465,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.05420000106096268,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/unconjugated-bilirubin","display_name":"unconjugated bilirubin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endothelial-cell-adhesion-molecules","display_name":"endothelial adhesion molecules","score":0.9160000085830688},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8939999938011169},{"id":"https://openalex.org/keywords/neutrophil-endothelial-adhesion","display_name":"neutrophil-endothelial adhesion","score":0.8529999852180481},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.6290000081062317},{"id":"https://openalex.org/keywords/dithiocarbamates","display_name":"dithiocarbamates","score":0.8059999942779541},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.7329623699188232},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6778348088264465},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.6455981135368347},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6242262125015259},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.6007790565490723},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5313589572906494},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.5288202166557312},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5089428424835205},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4979681968688965},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.4746430814266205},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.4608907103538513},{"id":"https://openalex.org/C2780983412","wikidata":"https://www.wikidata.org/wiki/Q7263769","display_name":"Pyrrolidine dithiocarbamate","level":4,"score":0.4524884521961212},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.44052568078041077},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.4296235740184784},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4141445755958557},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.375718355178833},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2843318581581116},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22378897666931152},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.20250234007835388},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19100666046142578},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15636411309242249},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13909736275672913},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.055629998445510864},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013859","descriptor_name":"Thiocarbamates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D050882","descriptor_name":"CREB-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:20103840","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20103840","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience trends","raw_type":"Journal Article"},{"id":"pmh:oai:arts.units.it:11368/2491357","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11368/2491357","pdf_url":null,"source":{"id":"https://openalex.org/S4306400480","display_name":"ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142444530","host_organization_name":"University of Trieste","host_organization_lineage":["https://openalex.org/I142444530"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2186972201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20103840","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W37351408","https://openalex.org/W101745106","https://openalex.org/W113851309","https://openalex.org/W1673385631","https://openalex.org/W1911016451","https://openalex.org/W1976382352","https://openalex.org/W1976616659","https://openalex.org/W1993243592","https://openalex.org/W1994768568","https://openalex.org/W1998492261","https://openalex.org/W2000807692","https://openalex.org/W2001946904","https://openalex.org/W2003572756","https://openalex.org/W2008685835","https://openalex.org/W2028501194","https://openalex.org/W2032373647","https://openalex.org/W2046564695","https://openalex.org/W2055834907","https://openalex.org/W2071307185","https://openalex.org/W2077066306","https://openalex.org/W2087924560","https://openalex.org/W2089360513","https://openalex.org/W2108244474","https://openalex.org/W2108881007","https://openalex.org/W2123898551","https://openalex.org/W2129424806","https://openalex.org/W2149250436","https://openalex.org/W2150622162","https://openalex.org/W2151514508","https://openalex.org/W2162010936"],"related_works":["https://openalex.org/W2077066306","https://openalex.org/W7027104583","https://openalex.org/W2351470367","https://openalex.org/W921221884","https://openalex.org/W1591305896","https://openalex.org/W2029906506","https://openalex.org/W2273766033","https://openalex.org/W2151186546","https://openalex.org/W2364467179","https://openalex.org/W2266635609"],"abstract_inverted_index":{"We":[0],"have":[1],"recently":[2],"demonstrated":[3],"that":[4,94,106],"unconjugated":[5],"bilirubin":[6,135],"(UCB)":[7],"limits":[8],"the":[9,16,22,28,35,65,72,95,102,111,120,131],"overexpression":[10,112],"of":[11,44,51,68,75,82,88,113,119,134,138],"adhesion":[12,19,114],"molecules":[13,115],"and":[14,56,105],"inhibits":[15],"PMN":[17],"endothelial":[18],"induced":[20,77],"by":[21,40,78],"pro-inflammatory":[23],"cytokine":[24],"TNFalpha.":[25,79],"To":[26],"understand":[27],"molecular":[29],"events":[30],"involved":[31,100],"we":[32],"investigated":[33],"whether":[34],"inhibitory":[36,66],"effect":[37,67,109,133],"is":[38,98],"determined":[39],"a":[41,60],"direct":[42],"influence":[43],"UCB":[45,70,83,103,107],"on":[46,110],"different":[47],"nuclear":[48,73],"pathways.":[49],"Co-treatment":[50],"cells":[52],"with":[53],"UCB,":[54],"TNFalpha,":[55],"pyrridoline":[57],"dithiocarbamate":[58],"(PDTC),":[59],"NF-kappaB":[61,76,121],"inhibitor,":[62],"additively":[63],"enhanced":[64],"UCB.":[69],"prevented":[71],"translocation":[74],"The":[80],"failure":[81],"to":[84,129],"alter":[85],"TNFalpha-induced":[86],"phosphorylation":[87],"cAMP-response":[89],"element-binding":[90],"protein":[91],"(CREB)":[92],"suggested":[93],"CREB":[96],"pathway":[97],"not":[99],"in":[101],"inhibition":[104,118],"blunting":[108],"occurs":[116],"via":[117],"transduction":[122],"pathway.":[123],"Collectively":[124],"these":[125],"data":[126],"may":[127],"contribute":[128],"explain":[130],"protective":[132],"against":[136],"development":[137],"atherosclerosis.":[139]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}