{"id":"https://openalex.org/W2186942366","doi":null,"title":"Therapeutic benefit of intravenous administration of human umbilical cord blood- mononuclear cells following intracerebral hemorrhage in rat.","display_name":"Therapeutic benefit of intravenous administration of human umbilical cord blood- mononuclear cells following intracerebral hemorrhage in rat.","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W2186942366","mag":"2186942366","pmid":"https://pubmed.ncbi.nlm.nih.gov/23492836","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3586889"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3586889","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3586889/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3586889/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Basic Med Sci","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3586889/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016913732","display_name":"Masoumeh Seghatoleslam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Masoumeh Seghatoleslam","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070792726","display_name":"Mehdi Jalali","orcid":"https://orcid.org/0000-0002-9983-3533","observed_orcids":["https://orcid.org/0000-0002-9983-3533"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehdi Jalali","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085667470","display_name":"Mohammad Reza Nikravesh","orcid":"https://orcid.org/0000-0002-5500-4610","observed_orcids":["https://orcid.org/0000-0002-5500-4610"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad Reza Nikravesh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081215156","display_name":"Mahmoud Hosseini","orcid":"https://orcid.org/0000-0001-6425-5123","observed_orcids":["https://orcid.org/0000-0001-6425-5123","https://orcid.org/0000-0002-9843-3394"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mahmoud Hosseini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044621774","display_name":"Daryoush Hamidi Alamdari","orcid":"https://orcid.org/0000-0002-7196-6094","observed_orcids":["https://orcid.org/0000-0002-7196-6094"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daryoush Hamidi Alamdari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021283680","display_name":"Alireza Fazel","orcid":"https://orcid.org/0000-0002-1470-619X","observed_orcids":["https://orcid.org/0000-0002-1470-619X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alireza Fazel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3955,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.79034805,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"3","first_page":"860","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracerebral-hemorrhage","display_name":"intracerebral hemorrhage","score":0.9399999976158142},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.878000020980835},{"id":"https://openalex.org/keywords/mononuclear-cells","display_name":"mononuclear cells","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cell-transplantation","display_name":"cell transplantation","score":0.6639999747276306},{"id":"https://openalex.org/keywords/intravenous-cell-delivery","display_name":"intravenous cell delivery","score":0.7549999952316284},{"id":"https://openalex.org/keywords/neurological-recovery","display_name":"neurological recovery","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.8709999918937683},{"id":"https://openalex.org/keywords/collagenase-induced-hemorrhage","display_name":"collagenase-induced hemorrhage","score":0.8489999771118164},{"id":"https://openalex.org/keywords/brdu-labeling","display_name":"BrdU labeling","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8325015902519226},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.7513458728790283},{"id":"https://openalex.org/C2777094939","wikidata":"https://www.wikidata.org/wiki/Q1368943","display_name":"Intracerebral hemorrhage","level":3,"score":0.7077215909957886},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.6596824526786804},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.6464353799819946},{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.6322313547134399},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5942376255989075},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4896843731403351},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.44516557455062866},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4077973961830139},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3581324815750122},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1812559962272644},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14662903547286987},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07981085777282715},{"id":"https://openalex.org/C2777736543","wikidata":"https://www.wikidata.org/wiki/Q693442","display_name":"Subarachnoid hemorrhage","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3586889","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3586889/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3586889/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Basic Med Sci","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2595093","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3586889","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23492836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23492836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of basic medical sciences","raw_type":"Journal Article"},{"id":"mag:2186942366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23492836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3586889","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3586889/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3586889/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Basic Med Sci","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322855","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2186942366.pdf","grobid_xml":"https://content.openalex.org/works/W2186942366.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1492885923","https://openalex.org/W1966100365","https://openalex.org/W1966545752","https://openalex.org/W1968947739","https://openalex.org/W1974536104","https://openalex.org/W1983259364","https://openalex.org/W1987708197","https://openalex.org/W1994334993","https://openalex.org/W2002007761","https://openalex.org/W2002323142","https://openalex.org/W2005689995","https://openalex.org/W2012658246","https://openalex.org/W2026201919","https://openalex.org/W2026573219","https://openalex.org/W2026983332","https://openalex.org/W2034916016","https://openalex.org/W2038625220","https://openalex.org/W2047455245","https://openalex.org/W2056034889","https://openalex.org/W2068238408","https://openalex.org/W2068520577","https://openalex.org/W2070450284","https://openalex.org/W2070762575","https://openalex.org/W2071221548","https://openalex.org/W2076578647","https://openalex.org/W2086536132","https://openalex.org/W2089738396","https://openalex.org/W2098613866","https://openalex.org/W2100167607","https://openalex.org/W2101873759","https://openalex.org/W2103845617","https://openalex.org/W2110294329","https://openalex.org/W2122336699","https://openalex.org/W2125619731","https://openalex.org/W2126918518","https://openalex.org/W2139724490","https://openalex.org/W2142458545","https://openalex.org/W2153531211","https://openalex.org/W2156589326","https://openalex.org/W2160959923","https://openalex.org/W2163806130","https://openalex.org/W2164099182","https://openalex.org/W2166508103","https://openalex.org/W2168286065","https://openalex.org/W2174070608","https://openalex.org/W2181998537","https://openalex.org/W2182779370","https://openalex.org/W2219366437"],"related_works":["https://openalex.org/W7099450626","https://openalex.org/W2004118520","https://openalex.org/W2528396478","https://openalex.org/W2122336699","https://openalex.org/W2219366437","https://openalex.org/W3011973778","https://openalex.org/W2125619731","https://openalex.org/W2068580317","https://openalex.org/W2598834666","https://openalex.org/W2383691741"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Human":[1],"umbilical":[2],"cord":[3],"blood":[4],"(HUCB)":[5],"is":[6],"now":[7],"considered":[8],"as":[9,106],"a":[10,32,249],"valuable":[11],"source":[12],"for":[13,136,253],"stem":[14],"cell-based":[15,254],"therapies.":[16],"Previous":[17],"studies":[18],"showed":[19,192],"that":[20,125],"intravascular":[21],"injection":[22],"of":[23,35,73,113,130,152,161,235],"the":[24,40,81,110,165,181,203,215,223,240],"HUCB":[25,46],"significantly":[26],"improves":[27],"neurological":[28,58,232],"functional":[29,153,196,216],"recovery":[30,217,234],"in":[31,60,75,100,164,214,256],"rat":[33,237],"model":[34],"intracerebral":[36],"hemorrhage":[37],"(ICH).":[38],"In":[39],"present":[41],"study,":[42],"we":[43],"hypothesize":[44],"transplanted":[45,176,190,229],"derived":[47],"mononuclear":[48],"cells":[49,99,163,246],"(UC-MCs)":[50],"can":[51],"decrease":[52],"injured":[53,186,219],"volume":[54,220],"and":[55,97,150,184,205,218,238],"also":[56,121],"ameliorate":[57],"function":[59,233],"ICH":[61,67,236],"rats.":[62,76],"MATERIALS":[63],"AND":[64],"METHODS:":[65],"Experimental":[66],"was":[68,120,168,211],"induced":[69],"by":[70,146,170],"intrastriatal":[71],"administration":[72],"collagenase":[74],"One":[77],"day":[78],"after":[79,198],"surgery,":[80],"rats":[82],"were":[83,134,144,155],"divided":[84],"into":[85],"3":[86],"groups":[87,191,207],"to":[88,180],"receive":[89],"intravenously":[90],"either":[91],"BrdU":[92],"positive":[93],"human":[94],"UC-MCs":[95,143,177,189,230],"[(4\u00d710(6)":[96],"8\u00d710(6)":[98],"1":[101],"ml":[102],"saline,":[103],"n=10":[104],"respectively)":[105],"treated":[107,225],"groups]":[108],"or":[109],"same":[111],"amount":[112],"saline":[114],"[as":[115],"lesion":[116,204,242],"group":[117,123],"(n=10)].":[118],"There":[119,210],"one":[122],"(control)":[124],"received":[126],"only":[127],"vehicle":[128],"solution":[129],"collagenase.":[131],"The":[132,188],"animals":[133],"evaluated":[135],"14":[137],"days":[138],"with":[139,202],"behavioral":[140],"tests.":[141],"Transplanted":[142],"detected":[145],"immunohistochemistry.":[147],"Histological":[148],"data":[149],"scores":[151],"tests":[154,197],"analyzed":[156],"using":[157],"ANOVA.":[158],"Cellular":[159],"co-localization":[160],"BrdU+":[162],"histological":[166],"slides":[167],"determined":[169],"software":[171],"Image":[172],"J.":[173],"RESULTS:":[174],"Intravenously":[175,228],"migrated":[178],"selectively":[179],"hematomal":[182],"area":[183],"reduce":[185],"volume.":[187],"better":[193],"performance":[194],"on":[195],"2":[199,224],"weeks":[200],"compared":[201],"control":[206],"(P<":[208],"0.05).":[209],"no":[212],"difference":[213],"improvement":[221],"between":[222],"groups.":[226],"CONCLUSION:":[227],"accelerate":[231],"diminish":[239],"striatum":[241],"size.":[243],"Thus":[244],"these":[245],"may":[247],"provide":[248],"potential":[250],"cell":[251],"candidate":[252],"therapy":[255],"ICH.":[257]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}