{"id":"https://openalex.org/W2186901237","doi":null,"title":"Intracerebroventricular administrations of angiotensin IV (Ang IV) ameliorate cognitive disorder in diabetic rats","display_name":"Intracerebroventricular administrations of angiotensin IV (Ang IV) ameliorate cognitive disorder in diabetic rats","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2186901237","mag":"2186901237"},"language":"en","primary_location":{"id":"mag:2186901237","doi":null,"is_oa":false,"landing_page_url":"http://neurology-asia.org/articles/neuroasia-2013-18(2)-195.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101435030","display_name":"Huimin Du","orcid":"https://orcid.org/0000-0002-9330-0488","observed_orcids":["https://orcid.org/0000-0002-9330-0488"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huimin Du","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9330-0488","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102438605","display_name":"Bailin Niu","orcid":"https://orcid.org/0000-0001-9582-7884","observed_orcids":["https://orcid.org/0000-0001-9582-7884"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bailin Niu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103547709","display_name":"Kexiang Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kexiang Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081541330","display_name":"Juan Li Mms","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan Li Mms","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5043229658","display_name":"Qian Xiao","orcid":"https://orcid.org/0000-0001-8855-6561","observed_orcids":["https://orcid.org/0000-0001-8855-6561"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qian Xiao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8855-6561","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18636943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.4916999936103821,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.4916999936103821,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.21140000224113464,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.06390000134706497,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-iv","display_name":"angiotensin IV","score":1.0},{"id":"https://openalex.org/keywords/diabetic-cognitive-impairment","display_name":"diabetic cognitive impairment","score":0.8799999952316284},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.6480000019073486},{"id":"https://openalex.org/keywords/synaptophysin","display_name":"synaptophysin","score":0.8479999899864197},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7009999752044678},{"id":"https://openalex.org/keywords/ca1-region","display_name":"CA1 region","score":0.6940000057220459},{"id":"https://openalex.org/keywords/synaptic-ultrastructure","display_name":"synaptic ultrastructure","score":0.871999979019165},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.875},{"id":"https://openalex.org/keywords/intracerebroventricular-injection","display_name":"intracerebroventricular administration","score":0.875},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C2777209535","wikidata":"https://www.wikidata.org/wiki/Q14864388","display_name":"Synaptophysin","level":3,"score":0.9650390148162842},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.8599238395690918},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.7658301591873169},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6210117936134338},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5915999412536621},{"id":"https://openalex.org/C50493954","wikidata":"https://www.wikidata.org/wiki/Q18031806","display_name":"Synapsin I","level":5,"score":0.5125420093536377},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4361904561519623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4313734173774719},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.42557352781295776},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38461846113204956},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3441879153251648},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.3390112519264221},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.25990745425224304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2502460479736328},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2186901237","doi":null,"is_oa":false,"landing_page_url":"http://neurology-asia.org/articles/neuroasia-2013-18(2)-195.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1969964985","https://openalex.org/W1984009511","https://openalex.org/W1991157941","https://openalex.org/W1998959104","https://openalex.org/W2014786210","https://openalex.org/W2017213641","https://openalex.org/W2021558843","https://openalex.org/W2024813257","https://openalex.org/W2025326529","https://openalex.org/W2027424219","https://openalex.org/W2031017779","https://openalex.org/W2032605307","https://openalex.org/W2045263244","https://openalex.org/W2058813140","https://openalex.org/W2061411812","https://openalex.org/W2062635423","https://openalex.org/W2064426755","https://openalex.org/W2067216327","https://openalex.org/W2067861079","https://openalex.org/W2068690756","https://openalex.org/W2092619571","https://openalex.org/W2112256576","https://openalex.org/W2138816348"],"related_works":["https://openalex.org/W2118135128","https://openalex.org/W2388969122","https://openalex.org/W2381650715","https://openalex.org/W3173643591","https://openalex.org/W370347728","https://openalex.org/W4410821844","https://openalex.org/W2371621028","https://openalex.org/W2368268320","https://openalex.org/W2361393425","https://openalex.org/W2357067397"],"abstract_inverted_index":{"Cognitive":[0],"impairment":[1,154],"is":[2,28],"a":[3,19],"common":[4],"complication":[5],"of":[6,54,69,102,122,165,177,202,212,218],"diabetes.":[7],"Hippocampus":[8],"plays":[9,194],"an":[10,195],"important":[11,196],"role":[12,197],"in":[13,25,124,144,167,179,198,220],"cognitive":[14,52,58,96,153,200],"function.":[15],"In":[16],"hyperglycemia,":[17],"synaptophysin,":[18],"crucial":[20],"synaptic":[21],"vesicle":[22],"membrane":[23],"protein":[24,119,175],"hippocampus":[26,125,168,180],"neuron":[27],"found":[29],"to":[30],"be":[31],"down-regulated.":[32],"Recent":[33],"evidences":[34],"have":[35],"shown":[36],"that":[37,143,191],"angiotensin":[38,91,149,192],"IV":[39,92,150,193],"can":[40,49],"facilitate":[41],"memory":[42,101],"acquisition":[43],"and":[44,60,88,100,118,136,174,214],"recovery.":[45],"However,":[46],"whether":[47],"it":[48],"also":[50],"improve":[51],"functions":[53],"diabetic":[55,86,146,187,203],"rats":[56,78,104,147],"with":[57,90,148,186],"disorder,":[59],"the":[61,67,103,145,152,163,170,210,216],"possible":[62,206],"mechanisms":[63,207],"are":[64,208],"uncertain.":[65],"Hence,":[66],"objectives":[68],"this":[70],"study.":[71],"Forty":[72],"fi":[73],"ve":[74],"Sprague":[75],"Dawley":[76],"male":[77],"were":[79,105,128],"randomly":[80],"divided":[81],"into":[82],"three":[83],"groups:":[84],"Control,":[85],"group":[87],"diabetes":[89],"treatment":[93],"group.":[94],"The":[95,112,205],"functions,":[97],"mainly":[98],"learning":[99],"evaluated":[106],"using":[107,130],"Morris":[108,158],"water":[109,159],"maze":[110,160],"task.":[111],"synapses":[113,166,219],"ultrastructure,":[114],"relative":[115,171],"mRNA":[116,172],"concentrations":[117,173],"expression":[120,211],"levels":[121,176],"synaptophysin":[123,178,213],"CA1":[126],"area":[127],"estimated":[129],"transmission":[131],"electron":[132],"microscope,":[133],"RT-PCR,":[134],"immunohistochemistry":[135],"western":[137],"blotting,":[138],"respectively.":[139],"Our":[140],"study":[141],"showed":[142],"treatment,":[151],"as":[155],"measured":[156],"by":[157],"task":[161],"improved,":[162],"ultrastructure":[164,217],"reversed,":[169],"signifi":[181],"cantly":[182],"increased,":[183],"when":[184],"compared":[185],"rats.":[188,204],"We":[189],"conclude":[190],"improving":[199],"function":[201],"up-regulating":[209],"normalizing":[215],"hippocampus.":[221]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}