{"id":"https://openalex.org/W2186744753","doi":null,"title":"Taking a Toll in Brain: Role of TLR4","display_name":"Taking a Toll in Brain: Role of TLR4","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2186744753","mag":"2186744753"},"language":"en","primary_location":{"id":"mag:2186744753","doi":null,"is_oa":false,"landing_page_url":"https://ijcmas.com/vol-4-4/Jayalakshmi%20Krishnan.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041161589","display_name":"Jayalakshmi Krishnan","orcid":"https://orcid.org/0000-0003-3098-5755","observed_orcids":["https://orcid.org/0000-0003-3098-5755"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jayalakshmi Krishnan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3098-5755","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041161589"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.5404999852180481,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.5404999852180481,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.45019999146461487,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9409999847412109},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7279999852180481},{"id":"https://openalex.org/keywords/pathogen-associated-molecular-patterns","display_name":"pathogen-associated molecular patterns","score":0.8270000219345093},{"id":"https://openalex.org/keywords/damage-associated-molecular-patterns","display_name":"damage-associated molecular patterns","score":0.996999979019165},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/glial-cells","display_name":"glial cells","score":0.6819999814033508},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.7289999723434448},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9359999895095825},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6840218305587769},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6480098962783813},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6331056952476501},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5730525255203247},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.5687847137451172},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.5620166063308716},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5589277744293213},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.546371340751648},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.5132160186767578},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49056047201156616},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47398248314857483},{"id":"https://openalex.org/C2993493390","wikidata":"https://www.wikidata.org/wiki/Q5453208","display_name":"First line","level":2,"score":0.46802669763565063},{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.4679117798805237},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39285239577293396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12427836656570435},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07750654220581055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2186744753","doi":null,"is_oa":false,"landing_page_url":"https://ijcmas.com/vol-4-4/Jayalakshmi%20Krishnan.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W202396504","https://openalex.org/W1487368140","https://openalex.org/W1503511302","https://openalex.org/W1537143297","https://openalex.org/W1606879955","https://openalex.org/W1761714741","https://openalex.org/W1937826833","https://openalex.org/W1971963029","https://openalex.org/W1972936661","https://openalex.org/W1975931952","https://openalex.org/W1976010325","https://openalex.org/W1977580387","https://openalex.org/W1977968562","https://openalex.org/W1977985161","https://openalex.org/W1982170042","https://openalex.org/W1984011020","https://openalex.org/W1984808884","https://openalex.org/W1987066375","https://openalex.org/W1988178045","https://openalex.org/W1988261409","https://openalex.org/W1988782375","https://openalex.org/W1990094847","https://openalex.org/W1993132466","https://openalex.org/W1994172493","https://openalex.org/W1995650166","https://openalex.org/W1995744610","https://openalex.org/W2000547390","https://openalex.org/W2001574852","https://openalex.org/W2008509697","https://openalex.org/W2010966794","https://openalex.org/W2011103417","https://openalex.org/W2011841911","https://openalex.org/W2012628595","https://openalex.org/W2012874552","https://openalex.org/W2018389491","https://openalex.org/W2023256158","https://openalex.org/W2034947369","https://openalex.org/W2037083212","https://openalex.org/W2039813398","https://openalex.org/W2040419928","https://openalex.org/W2046015931","https://openalex.org/W2048721710","https://openalex.org/W2051227412","https://openalex.org/W2051633940","https://openalex.org/W2054407849","https://openalex.org/W2063081068","https://openalex.org/W2064935465","https://openalex.org/W2066384268","https://openalex.org/W2074625678","https://openalex.org/W2075167067","https://openalex.org/W2080709645","https://openalex.org/W2080730204","https://openalex.org/W2081047269","https://openalex.org/W2083212512","https://openalex.org/W2089261234","https://openalex.org/W2093437371","https://openalex.org/W2112663559","https://openalex.org/W2114037757","https://openalex.org/W2119868521","https://openalex.org/W2120449355","https://openalex.org/W2124667416","https://openalex.org/W2128132289","https://openalex.org/W2130145174","https://openalex.org/W2131156766","https://openalex.org/W2144679012","https://openalex.org/W2148274266","https://openalex.org/W2149927155","https://openalex.org/W2155783053","https://openalex.org/W2165485914","https://openalex.org/W2395422150","https://openalex.org/W2588771141"],"related_works":["https://openalex.org/W2024660851","https://openalex.org/W2379991910","https://openalex.org/W8387223","https://openalex.org/W7011771077","https://openalex.org/W4252547894","https://openalex.org/W2134722392","https://openalex.org/W3201586063","https://openalex.org/W2104008608","https://openalex.org/W2043367837","https://openalex.org/W4254876619"],"abstract_inverted_index":{"Toll":[0],"like":[1],"receptors":[2,9],"(TLRs)":[3],"are":[4,85,96],"well":[5],"known":[6],"archetypal":[7],"transmembrane":[8],"which":[10],"initiate":[11],"the":[12,40,59,73],"innate":[13],"immune":[14,41,92],"responses":[15],"(Akira":[16],"et":[17,81],"al.,":[18,82],"2006).":[19,83],"TLRs":[20,84],"can":[21],"recognize":[22],"both":[23],"Pathogen":[24],"Associated":[25,31],"Molecular":[26,32],"Patterns":[27,33],"(PAMPs)":[28],"and":[29,50,89,104],"Damage":[30],"(DAMPs).As":[34],"a":[35,44],"consequence":[36],"of":[37,47,62,76],"TLR4":[38],"activation":[39,71],"cells":[42,93,100],"release":[43],"wide":[45],"variety":[46],"chemokines,":[48],"cytokines":[49],"inflammatory":[51],"mediators":[52],"by":[53,68],"transcriptional":[54],"regulation.":[55],"Adaptive":[56],"immunity":[57],"is":[58,65],"second":[60],"line":[61,75],"defence":[63,77],"but":[64,94],"primarily":[66],"activated":[67],"TLRs,":[69],"whose":[70],"forms":[72],"first":[74],"(Mills":[78],"2011,":[79],"Akira":[80],"not":[86],"only":[87],"expressed":[88,97],"functional":[90],"in":[91,98],"they":[95],"non-immune":[99],"such":[101],"as":[102],"neurons":[103],"glial":[105],"ISSN:":[106],"2319-7706":[107],"Volume":[108],"4":[109,111],"Number":[110],"(2015)":[112],"pp.":[113],"283-296":[114],"http://www.ijcmas.com":[115]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}