{"id":"https://openalex.org/W2186733112","doi":null,"title":"Development of a Curated Database of In Vivo Estrogenic Activity","display_name":"Development of a Curated Database of In Vivo Estrogenic Activity","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2186733112","mag":"2186733112"},"language":"en","primary_location":{"id":"mag:2186733112","doi":null,"is_oa":false,"landing_page_url":"https://ntp.niehs.nih.gov/iccvam/meetings/9wc/posters/ceger-edlitrev-fd-text.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027816145","display_name":"Patricia C. Ceger","orcid":"https://orcid.org/0000-0002-5167-9928","observed_orcids":["https://orcid.org/0000-0002-5167-9928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia Ceger","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5167-9928","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084541486","display_name":"Nicole Kleinstreuer","orcid":"https://orcid.org/0000-0002-7914-3682","observed_orcids":["https://orcid.org/0000-0002-7914-3682"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole Kleinstreuer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7914-3682","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048213094","display_name":"Xiaoqing Chang","orcid":"https://orcid.org/0000-0003-0752-1848","observed_orcids":["https://orcid.org/0000-0003-0752-1848"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoqing Chang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0752-1848","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Brenda B. Jones","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brenda B. Jones","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111842608","display_name":"Jon T. Hamm","orcid":"https://orcid.org/0000-0001-5664-8349","observed_orcids":["https://orcid.org/0000-0001-5664-8349"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jon Hamm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024010660","display_name":"Lori A. Rinckel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lori A. Rinckel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064332538","display_name":"Daniel Miller Rotroff","orcid":"https://orcid.org/0000-0003-0553-3220","observed_orcids":["https://orcid.org/0000-0003-0553-3220","https://orcid.org/0000-0001-6031-9927"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel M. Rotroff","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0553-3220","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040691234","display_name":"Judy A. Strickland","orcid":"https://orcid.org/0000-0002-4112-7484","observed_orcids":["https://orcid.org/0000-0002-4112-7484"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Judy Strickland","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4112-7484","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025969084","display_name":"David Allen","orcid":"https://orcid.org/0000-0002-8575-9547","observed_orcids":["https://orcid.org/0000-0002-8575-9547"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Allen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8575-9547","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4393,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.65078991,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogenic-activity","display_name":"estrogenic activity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/curated-database","display_name":"curated database","score":0.8370000123977661},{"id":"https://openalex.org/keywords/reference-compounds","display_name":"reference compounds","score":0.628000020980835},{"id":"https://openalex.org/keywords/data-quality-assessment","display_name":"data quality assessment","score":0.9169999957084656},{"id":"https://openalex.org/keywords/uterotrophic-effect","display_name":"uterotrophic effect","score":0.6700000166893005},{"id":"https://openalex.org/keywords/multigenerational-toxicity","display_name":"multigenerational toxicity","score":0.8140000104904175},{"id":"https://openalex.org/keywords/chemical-prioritization","display_name":"chemical prioritization","score":0.7570000290870667},{"id":"https://openalex.org/keywords/ontology-standardization","display_name":"ontology standardization","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.570362389087677},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5599939227104187},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.4148215353488922},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17050513625144958},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2186733112","doi":null,"is_oa":false,"landing_page_url":"https://ntp.niehs.nih.gov/iccvam/meetings/9wc/posters/ceger-edlitrev-fd-text.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1535188141","https://openalex.org/W1661470104","https://openalex.org/W1939546123","https://openalex.org/W2034761114","https://openalex.org/W2079712252","https://openalex.org/W2122025333","https://openalex.org/W2171283857"],"related_works":["https://openalex.org/W2530296011","https://openalex.org/W4385980220","https://openalex.org/W2118982904","https://openalex.org/W2429101022","https://openalex.org/W3211042828","https://openalex.org/W2004972452","https://openalex.org/W2895068315","https://openalex.org/W7097387079","https://openalex.org/W2087836560","https://openalex.org/W2071113470"],"abstract_inverted_index":{"Currently":[0],"mandated":[1],"testing":[2,92],"for":[3,60,77,122,199],"potential":[4],"estrogenic":[5,69,107,131,208],"activity":[6,70],"will":[7],"involve":[8],"thousands":[9],"of":[10,14,41,51,68,75,109,129,160,207],"chemicals,":[11],"cost":[12],"millions":[13],"dollars,":[15],"and":[16,27,38,64,71,94,117,145,171,203],"take":[17],"decades":[18],"to":[19,47,156,164,182],"complete":[20],"using":[21,147],"current":[22,84],"validated":[23],"tests.":[24],"High-throughput":[25],"screening":[26],"computational":[28],"toxicology":[29,56],"tools":[30],"may":[31],"streamline":[32],"this":[33],"process":[34],"by":[35,114],"the":[36,73,83,96,106,115,141,158,161,183,189],"quick":[37],"cost-effective":[39],"identification":[40],"endocrine":[42],"active":[43],"chemicals":[44,76,112,125],"(EACs).":[45],"Access":[46],"a":[48,99,127,148,196],"comprehensive":[49],"database":[50,194],"high-quality":[52,88],"in":[53,62,65,89,168,201,204],"vivo":[54,90],"EAC":[55,91],"data":[57,97,121,162],"is":[58,186],"critical":[59,197],"validating":[61,200],"vitro":[63,202],"silico":[66,205],"models":[67,206],"supporting":[72],"prioritization":[74],"further":[78],"testing.":[79],"Accordingly,":[80],"we":[81],"reviewed":[82],"scientific":[85],"literature,":[86],"identified":[87],"data,":[93],"compiled":[95,146],"into":[98],"single":[100],"database.":[101],"Initial":[102],"review":[103],"focused":[104],"on":[105,126,188],"effects":[108],"52":[110,124],"reference":[111],"selected":[113],"EPA":[116],"NTP.":[118],"Studies":[119],"including":[120],"these":[123],"number":[128],"different":[130],"endpoints":[132],"(uterotrophic,":[133],"pubertal,":[134],"multigenerational,":[135],"etc.)":[136],"were":[137,143,176,180],"identified.":[138],"Data":[139,174],"from":[140],"studies":[142],"extracted":[144],"standardized":[149,172],"ontology.":[150],"An":[151],"R":[152],"script":[153],"was":[154],"developed":[155],"evaluate":[157],"quality":[159],"according":[163],"modified":[165],"Klimisch":[166],"criteria":[167],"an":[169],"efficient":[170],"manner.":[173],"that":[175],"classified":[177],"as":[178],"reliable":[179],"added":[181],"database,":[184],"which":[185],"available":[187],"NTP":[190],"website":[191],"(http://ntp.niehs.nih.gov/go/40658).":[192],"This":[193],"constitutes":[195],"resource":[198],"activity.":[209]},"counts_by_year":[{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
