{"id":"https://openalex.org/W2186648479","doi":null,"title":"Diverse prognostic roles of Akt isoforms, PTEN and PI3K in tumor epithelial cells and stromal compartment in non-small cell lung cancer.","display_name":"Diverse prognostic roles of Akt isoforms, PTEN and PI3K in tumor epithelial cells and stromal compartment in non-small cell lung cancer.","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W2186648479","mag":"2186648479","pmid":"https://pubmed.ncbi.nlm.nih.gov/19846969"},"language":"en","primary_location":{"id":"pmid:19846969","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19846969","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086917791","display_name":"Samer Al\u2010Saad","orcid":"https://orcid.org/0000-0003-3707-9667","observed_orcids":["https://orcid.org/0000-0003-3707-9667"]},"institutions":[{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Samer Al-Saad","raw_affiliation_strings":["Institute of Medical Biology, University of Tromso, Norway. samer.al-saad@unn.no","Institute of Medical Biology University of Troms\u00d8, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Biology, University of Tromso, Norway. samer.al-saad@unn.no","institution_ids":["https://openalex.org/I78037679"]},{"raw_affiliation_string":"Institute of Medical Biology University of Troms\u00d8, Norway","institution_ids":["https://openalex.org/I78037679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021379707","display_name":"Tom D\u00f8nnem","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tom Donnem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015431535","display_name":"Khalid I. Al-Shibli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khalid Al-Shibli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Magnus Persson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magnus Persson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081738251","display_name":"Roy Martin Bremnes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roy M Bremnes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084207494","display_name":"Lill\u2010Tove Busund","orcid":"https://orcid.org/0000-0001-8235-6163","observed_orcids":["https://orcid.org/0000-0001-8235-6163"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lill-Tove Busund","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5274,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.80451385,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"29","issue":"10","first_page":"4175","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.040800001472234726,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9760000109672546},{"id":"https://openalex.org/keywords/akt-isoforms","display_name":"Akt isoforms","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.8149999976158142},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/akt2","display_name":"AKT2","score":0.7260000109672546},{"id":"https://openalex.org/keywords/akt3","display_name":"AKT3","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tumor-epithelial-cells","display_name":"tumor epithelial cells","score":0.8579999804496765},{"id":"https://openalex.org/keywords/disease-specific-survival","display_name":"disease-specific survival","score":0.8309999704360962},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9200000166893005},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.8342244625091553},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.745789110660553},{"id":"https://openalex.org/C193270364","wikidata":"https://www.wikidata.org/wiki/Q17141925","display_name":"Tissue microarray","level":3,"score":0.6450474262237549},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5652697086334229},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5563327074050903},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5309286713600159},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5128083825111389},{"id":"https://openalex.org/C88216763","wikidata":"https://www.wikidata.org/wiki/Q4652205","display_name":"AKT2","level":5,"score":0.49760106205940247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47746896743774414},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.47411420941352844},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4641469717025757},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42560991644859314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41064274311065674},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3055872321128845},{"id":"https://openalex.org/C154137905","wikidata":"https://www.wikidata.org/wiki/Q17816452","display_name":"AKT1","level":4,"score":0.18533778190612793},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.11474776268005371},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:19846969","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19846969","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2186648479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19846969","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W259875475","https://openalex.org/W1509610657","https://openalex.org/W1610645793","https://openalex.org/W1726025741","https://openalex.org/W1969337484","https://openalex.org/W1974007392","https://openalex.org/W1984418041","https://openalex.org/W2023898364","https://openalex.org/W2039193709","https://openalex.org/W2060942394","https://openalex.org/W2061673659","https://openalex.org/W2072950603","https://openalex.org/W2078312014","https://openalex.org/W2081419851","https://openalex.org/W2085781596","https://openalex.org/W2094079572","https://openalex.org/W2099658407","https://openalex.org/W2100243911","https://openalex.org/W2106787323","https://openalex.org/W2109181262","https://openalex.org/W2112620000","https://openalex.org/W2114248978","https://openalex.org/W2114311689","https://openalex.org/W2125649123","https://openalex.org/W2127878747","https://openalex.org/W2129030388","https://openalex.org/W2131290484","https://openalex.org/W2132292320","https://openalex.org/W2134037189","https://openalex.org/W2146157811","https://openalex.org/W2161972823","https://openalex.org/W2162821704","https://openalex.org/W2526478062"],"related_works":["https://openalex.org/W2023898364","https://openalex.org/W1509610657","https://openalex.org/W2362635438","https://openalex.org/W2114750875","https://openalex.org/W2387540317","https://openalex.org/W1481100573","https://openalex.org/W2374315858","https://openalex.org/W2012843314","https://openalex.org/W1001643363","https://openalex.org/W2365339938"],"abstract_inverted_index":{"AIM:":[0],"By":[1],"tissue":[2,32,56,78,97,116],"microarray":[3],"methodology,":[4],"the":[5,68,171,186],"expression":[6,69,92,111,126,145,156,177,189,204,210,233],"of":[7,70,85,127,146,157,178,190,205,211,221,234],"altered":[8],"Akt":[9],"isoforms,":[10],"PTEN":[11,91],"and":[12,14,35,53,161,182,185,193,208,237],"PI3K":[13,110,163,194,239],"their":[15],"prognostic":[16,134,198,244],"significance":[17],"in":[18,38,57,95,112,214,224],"335":[19,39],"non-small":[20],"cell":[21,125,144,176,188],"lung":[22,77],"cancer":[23],"(NSCLC)":[24],"tumors":[25,40],"were":[26,61,196],"investigated.":[27],"PATIENTS":[28],"AND":[29],"METHODS:":[30],"Tumor":[31],"was":[33,73,93,104,131,150],"sampled":[34],"immunohistochemically":[36],"quantified":[37],"from":[41,49,80],"stage":[42],"I":[43],"to":[44,75],"IIIA":[45],"NSCLC":[46],"patients":[47,81,225],"both":[48,241],"tumor":[50,101,115,123,142,174,215],"epithelial":[51,124,143,175,216],"cells":[52,217],"surrounding":[54],"stromal":[55,155,187,230],"resected":[58],"specimens.":[59],"Correlations":[60],"made":[62],"with":[63,100,166,226],"clinicopathological":[64],"variables.":[65],"In":[66,119,170,229],"addition,":[67],"these":[71],"markers":[72],"compared":[74,99],"20":[76],"cores":[79],"without":[82],"any":[83],"history":[84],"malignancy.":[86],"RESULTS:":[87],"A":[88],"significantly":[89,106],"higher":[90],"observed":[94],"control":[96,113],"when":[98],"(p=0.001).":[102],"There":[103],"a":[105,132,151,167],"negative":[107,152],"correlation":[108],"between":[109],"versus":[114],"(p=0.001,":[117],"r=-0.2).":[118],"univariate":[120],"analyses,":[121],"high":[122,141,232],"non-phosphorylated":[128,206],"Akt2":[129,183,207],"(p=0.014)":[130],"positive":[133],"indicator":[135],"for":[136,200],"disease-specific":[137],"survival":[138,223],"(DSS),":[139],"while":[140],"p-Akt":[147,179,212],"Thr(308)":[148,180,213],"(p=0.045)":[149],"prognosticator.":[153],"High":[154,203],"total":[158,162,235,238],"Akt3":[159,191,236],"(p=0.0008)":[160,192],"(p=0.0003)":[164],"correlated":[165],"good":[168],"prognosis.":[169],"multivariate":[172],"analysis,":[173],"(p=0.0009)":[181],"(p=0.004)":[184],"(p=0.012)":[195],"independent":[197,219,243],"factors":[199],"DSS.":[201],"CONCLUSION:":[202],"low":[209],"are":[218,240],"predictors":[220],"improved":[222],"primary":[227],"NSCLC.":[228],"cells,":[231],"favourable":[242],"indicators.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}