{"id":"https://openalex.org/W2186612937","doi":"https://doi.org/10.14670/hh-19.715","title":"Expression of prostate specific membrane antigen (PSMA) in prostatic adenocarcinoma and prostatic intraepithelial neoplasia.","display_name":"Expression of prostate specific membrane antigen (PSMA) in prostatic adenocarcinoma and prostatic intraepithelial neoplasia.","publication_year":2004,"publication_date":"2004-07-01","ids":{"openalex":"https://openalex.org/W2186612937","doi":"https://doi.org/10.14670/hh-19.715","mag":"2186612937","pmid":"https://pubmed.ncbi.nlm.nih.gov/15168332"},"language":"en","primary_location":{"id":"pmid:15168332","doi":"https://doi.org/10.14670/hh-19.715","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15168332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histology and histopathology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10201/21601","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"C Marchal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087438","display_name":"Hospital Costa del Sol","ror":"https://ror.org/0065mvt73","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210087438"]},{"id":"https://openalex.org/I4210157384","display_name":"Agencia Sanitaria Costa del Sol","ror":"https://ror.org/045z30r81","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210152975","https://openalex.org/I4210157384","https://openalex.org/I918821925"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"C Marchal","raw_affiliation_strings":["Servicio de Urolog\u00eda, Hospital Costa del Sol, Marbella, M\u00e1laga, Spain. crmarchal@supercable.es","Servicio de Urolog\u00eda, Hospital Costa del Sol, Marbella, M\u00e1laga, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Urolog\u00eda, Hospital Costa del Sol, Marbella, M\u00e1laga, Spain. crmarchal@supercable.es","institution_ids":["https://openalex.org/I4210087438","https://openalex.org/I4210157384"]},{"raw_affiliation_string":"Servicio de Urolog\u00eda, Hospital Costa del Sol, Marbella, M\u00e1laga, Spain","institution_ids":["https://openalex.org/I4210087438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054868492","display_name":"Maximino Redondo","orcid":"https://orcid.org/0000-0001-5559-4246","observed_orcids":["https://orcid.org/0000-0001-5559-4246"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Redondo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070568283","display_name":"M Padilla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Padilla","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J Caballero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Caballero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111575852","display_name":"Isabel Rodrigo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Rodrigo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083601930","display_name":"Julia Garcia","orcid":"https://orcid.org/0000-0002-9218-039X","observed_orcids":["https://orcid.org/0000-0002-9218-039X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Garc\u00eda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065396798","display_name":"J Quian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Quian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017065370","display_name":"D G Boswick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D G Boswick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4909,"has_fulltext":true,"cited_by_count":129,"citation_normalized_percentile":{"value":0.88863353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"19","issue":"3","first_page":"715","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.6753000020980835,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.6753000020980835,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.3140000104904175,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-specific-membrane-antigen","display_name":"prostate-specific membrane antigen","score":0.9070000052452087},{"id":"https://openalex.org/keywords/prostate-adenocarcinoma","display_name":"prostate adenocarcinoma","score":0.8949999809265137},{"id":"https://openalex.org/keywords/prostatic-intraepithelial-neoplasia","display_name":"prostatic intraepithelial neoplasia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gleason-score","display_name":"Gleason score","score":0.9559999704360962},{"id":"https://openalex.org/keywords/benign-prostatic-epithelium","display_name":"benign prostatic epithelium","score":0.8130000233650208},{"id":"https://openalex.org/keywords/prostate-cancer-progression","display_name":"prostate cancer progression","score":0.7250000238418579},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.5540000200271606},{"id":"https://openalex.org/keywords/serum-psa","display_name":"serum PSA","score":0.7540000081062317},{"id":"https://openalex.org/keywords/immunohistochemical-markers","display_name":"immunohistochemical markers","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2779534503","wikidata":"https://www.wikidata.org/wiki/Q6058399","display_name":"Intraepithelial neoplasia","level":4,"score":0.8636223077774048},{"id":"https://openalex.org/C2776456063","wikidata":"https://www.wikidata.org/wiki/Q15731388","display_name":"High-grade prostatic intraepithelial neoplasia","level":5,"score":0.7451454401016235},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.7231126427650452},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7196294069290161},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7170356512069702},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5698739290237427},{"id":"https://openalex.org/C87874733","wikidata":"https://www.wikidata.org/wiki/Q18039844","display_name":"PCA3","level":4,"score":0.5685402750968933},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5646811127662659},{"id":"https://openalex.org/C20417620","wikidata":"https://www.wikidata.org/wiki/Q4140229","display_name":"Glutamate carboxypeptidase II","level":4,"score":0.5261337757110596},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.516746461391449},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.48274344205856323},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4496505856513977},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4403200149536133},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4335033893585205},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.193292498588562},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.058617085218429565}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019048","descriptor_name":"Prostatic Intraepithelial Neoplasia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019048","descriptor_name":"Prostatic Intraepithelial Neoplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmid:15168332","doi":"https://doi.org/10.14670/hh-19.715","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15168332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histology and histopathology","raw_type":"Comparative Study"},{"id":"pmh:oai:digitum.um.es:10201/21601","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/21601","pdf_url":"http://hdl.handle.net/10201/21601","source":{"id":"https://openalex.org/S4306401267","display_name":"Digitum: Institutional Repository of the University of Murcia (University of Murcia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80180929","host_organization_name":"Universidad de Murcia","host_organization_lineage":["https://openalex.org/I80180929"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dnet:digitum_____::dd06608676a03b4fc28e000046da4cea","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/21601","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:hispana.mcu.es:61680670","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/21601","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2186612937","doi":"https://doi.org/10.14670/hh-19.715","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15168332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitum.um.es:10201/21601","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/21601","pdf_url":"http://hdl.handle.net/10201/21601","source":{"id":"https://openalex.org/S4306401267","display_name":"Digitum: Institutional Repository of the University of Murcia (University of Murcia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80180929","host_organization_name":"Universidad de Murcia","host_organization_lineage":["https://openalex.org/I80180929"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320326754","display_name":"Junta de Andaluc\u00eda","ror":"https://ror.org/01jem9c82"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2186612937.pdf","grobid_xml":"https://content.openalex.org/works/W2186612937.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1523096697","https://openalex.org/W1558144205","https://openalex.org/W1573450491","https://openalex.org/W1916477575","https://openalex.org/W1975310412","https://openalex.org/W2021102759","https://openalex.org/W2025610386","https://openalex.org/W2052122770","https://openalex.org/W2053554578","https://openalex.org/W2063649715","https://openalex.org/W2091479445","https://openalex.org/W2162159594","https://openalex.org/W2394669656"],"related_works":["https://openalex.org/W7000597513","https://openalex.org/W7065661694","https://openalex.org/W2380359166","https://openalex.org/W2095044777","https://openalex.org/W2384273955","https://openalex.org/W2350783982","https://openalex.org/W2053554578","https://openalex.org/W2163470211","https://openalex.org/W4414374121","https://openalex.org/W1977388865"],"abstract_inverted_index":{"The":[0,80],"prostatic":[1,13,45,53,104],"membrane":[2],"antigen":[3],"(PSMA)":[4],"is":[5,9,137,143,154],"a":[6,22,70,118,146,155],"protein":[7],"that":[8,134],"expressed":[10],"in":[11,21,39,43,50,88,95,115,139],"the":[12,17,36,56,77],"epithelium.":[14],"We":[15,132],"studied":[16,66],"expression":[18,112],"of":[19,24,30,83,150,163],"PSMA":[20,37,75,84,111,135],"series":[23],"55":[25],"patients":[26],"with":[27,69,117,128,145],"different":[28],"stages":[29],"prostate":[31,40,89,151,164],"cancer":[32,41,90],"and":[33,49,93,142,161],"we":[34],"compared":[35],"staining":[38],"cells,":[42,92,97],"high-grade":[44,140],"intraepithelial":[46],"neoplasia":[47],"(PIN)":[48],"histologically":[51],"benign":[52],"epithelium":[54,105],"for":[55,158],"same":[57],"specimen.":[58],"For":[59],"this":[60],"purpose":[61],"archival":[62],"paraffin-embedded":[63],"specimens":[64],"were":[65],"by":[67],"immunohistochemistry":[68],"monoclonal":[71],"antibody":[72],"7E11-C5.3":[73],"against":[74],"using":[76],"streptavidin-biotin":[78],"method.":[79],"mean":[81],"percentage":[82],"immunoreactivity":[85],"was":[86,99,113,126],"56.67%":[87],"(CaP)":[91],"48.6%":[94],"PIN":[96,141],"which":[98],"significantly":[100],"higher":[101,119,147],"than":[102],"benign-appearing":[103],"(5.72%)":[106],"(for":[107],"each":[108],"pair,":[109],"p<0.001).":[110],"greater":[114],"CaP":[116],"Gleason":[120,148],"score":[121,149],"(p=0.01),":[122],"but":[123],"no":[124],"relationship":[125],"found":[127],"serum":[129],"PSA":[130],"value.":[131],"conclude":[133],"overexpression":[136],"detected":[138],"associated":[144],"cancer.":[152,165],"It":[153],"potential":[156],"marker":[157],"studying":[159],"carcinogenesis":[160],"progression":[162]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
