{"id":"https://openalex.org/W2186574622","doi":"https://doi.org/10.1007/978-1-4684-8559-2_6","title":"Determinants of 5-Phosphoribosyl-1-Pyrophosphate (PRPP) Synthesis in Human Fibroblasts","display_name":"Determinants of 5-Phosphoribosyl-1-Pyrophosphate (PRPP) Synthesis in Human Fibroblasts","publication_year":1980,"publication_date":"1980-01-01","ids":{"openalex":"https://openalex.org/W2186574622","doi":"https://doi.org/10.1007/978-1-4684-8559-2_6","mag":"2186574622","pmid":"https://pubmed.ncbi.nlm.nih.gov/94761"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4684-8559-2_6","doi":"https://doi.org/10.1007/978-1-4684-8559-2_6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4684-8559-2_6","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4240518296","display_name":"Purine Metabolism in Man\u2014III"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111861493","display_name":"Kari O. Raivio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210090554","display_name":"Helsinki Children's Hospital","ror":"https://ror.org/00dqfzf20","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210090554","https://openalex.org/I4210166427"]}],"countries":["FI","US"],"is_corresponding":false,"raw_author_name":"Kari O. Raivio","raw_affiliation_strings":["Children\u2019s Hospital, University of Helsinki, Finland","Veterans Administration Hospital, San Diego, California, 92161, USA","Veterans Administration Hospital, San Diego, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210090554"]},{"raw_affiliation_string":"Veterans Administration Hospital, San Diego, California, 92161, USA","institution_ids":["https://openalex.org/I1322918889"]},{"raw_affiliation_string":"Veterans Administration Hospital, San Diego, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064501258","display_name":"Cheri S. Lazar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210090554","display_name":"Helsinki Children's Hospital","ror":"https://ror.org/00dqfzf20","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210090554","https://openalex.org/I4210166427"]}],"countries":["FI","US"],"is_corresponding":false,"raw_author_name":"Cheri Lazar","raw_affiliation_strings":["Children\u2019s Hospital, University of Helsinki, Finland","Veterans Administration Hospital, San Diego, California, 92161, USA","Veterans Administration Hospital, San Diego, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210090554"]},{"raw_affiliation_string":"Veterans Administration Hospital, San Diego, California, 92161, USA","institution_ids":["https://openalex.org/I1322918889"]},{"raw_affiliation_string":"Veterans Administration Hospital, San Diego, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082548132","display_name":"Henry Krumholz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210090554","display_name":"Helsinki Children's Hospital","ror":"https://ror.org/00dqfzf20","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210090554","https://openalex.org/I4210166427"]}],"countries":["FI","US"],"is_corresponding":false,"raw_author_name":"Henry Krumholz","raw_affiliation_strings":["Children\u2019s Hospital, University of Helsinki, Finland","Veterans Administration Hospital, San Diego, California, 92161, USA","Veterans Administration Hospital, San Diego, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210090554"]},{"raw_affiliation_string":"Veterans Administration Hospital, San Diego, California, 92161, USA","institution_ids":["https://openalex.org/I1322918889"]},{"raw_affiliation_string":"Veterans Administration Hospital, San Diego, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060122908","display_name":"Michael A. Becker","orcid":"https://orcid.org/0000-0002-9706-905X","observed_orcids":["https://orcid.org/0000-0002-9706-905X"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210090554","display_name":"Helsinki Children's Hospital","ror":"https://ror.org/00dqfzf20","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210090554","https://openalex.org/I4210166427"]}],"countries":["FI","US"],"is_corresponding":false,"raw_author_name":"Michael A. Becker","raw_affiliation_strings":["Children\u2019s Hospital, University of Helsinki, Finland","Veterans Administration Hospital, San Diego, California, 92161, USA","Veterans Administration Hospital, San Diego, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210090554"]},{"raw_affiliation_string":"Veterans Administration Hospital, San Diego, California, 92161, USA","institution_ids":["https://openalex.org/I1322918889"]},{"raw_affiliation_string":"Veterans Administration Hospital, San Diego, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2712,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.61818182,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"122B","issue":null,"first_page":"31","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12604","display_name":"Glycogen Storage Diseases and Myoclonus","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prpp-synthetase","display_name":"PRPP synthetase","score":0.984000027179718},{"id":"https://openalex.org/keywords/human-fibroblasts","display_name":"human fibroblasts","score":0.9049999713897705},{"id":"https://openalex.org/keywords/ribose-5-phosphate","display_name":"ribose-5-phosphate","score":0.8989999890327454},{"id":"https://openalex.org/keywords/enzyme-regulation","display_name":"enzyme regulation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/pentose-phosphate-shunt","display_name":"pentose phosphate shunt","score":0.8370000123977661},{"id":"https://openalex.org/keywords/nucleoside-phosphorylase","display_name":"nucleoside phosphorylase","score":0.9390000104904175},{"id":"https://openalex.org/keywords/ribose-1-phosphate","display_name":"ribose-1-phosphate","score":0.9020000100135803},{"id":"https://openalex.org/keywords/nucleotide-catabolism","display_name":"nucleotide catabolism","score":0.949999988079071}],"concepts":[{"id":"https://openalex.org/C3409486","wikidata":"https://www.wikidata.org/wiki/Q827489","display_name":"Pentose phosphate pathway","level":4,"score":0.826552152633667},{"id":"https://openalex.org/C2779461342","wikidata":"https://www.wikidata.org/wiki/Q59817493","display_name":"Ribose","level":3,"score":0.7624767422676086},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6640030741691589},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5899094939231873},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5862600803375244},{"id":"https://openalex.org/C71615608","wikidata":"https://www.wikidata.org/wiki/Q24720082","display_name":"Purine nucleoside phosphorylase","level":4,"score":0.5098711252212524},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5057754516601562},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.49130406975746155},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.4853607416152954},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.4723423719406128},{"id":"https://openalex.org/C2776043855","wikidata":"https://www.wikidata.org/wiki/Q55506489","display_name":"Pyrophosphate","level":3,"score":0.4537714421749115},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.4369509816169739},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.4238909184932709},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.2961188852787018},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008751","descriptor_name":"Methylene Blue","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010428","descriptor_name":"Pentosephosphates","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010754","descriptor_name":"Phosphoribosyl Pyrophosphate","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012267","descriptor_name":"Ribosemonophosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015120","descriptor_name":"6-Aminonicotinamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-4684-8559-2_6","doi":"https://doi.org/10.1007/978-1-4684-8559-2_6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4684-8559-2_6","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},{"id":"pmid:94761","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/94761","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W54700548","https://openalex.org/W1607830053","https://openalex.org/W1637127028","https://openalex.org/W1985342306"],"related_works":["https://openalex.org/W146259438","https://openalex.org/W1987430097","https://openalex.org/W1581281722","https://openalex.org/W62982060","https://openalex.org/W1992514797","https://openalex.org/W2016483637","https://openalex.org/W2310020101","https://openalex.org/W2073470515","https://openalex.org/W2013593850","https://openalex.org/W2083990094"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
