{"id":"https://openalex.org/W2186547716","doi":null,"title":"Rates and Physiologic Thresholds for Metabolic and Hemodynamic Actions in Man","display_name":"Rates and Physiologic Thresholds for Metabolic and Hemodynamic Actions in Man","publication_year":1980,"publication_date":"1980-01-01","ids":{"openalex":"https://openalex.org/W2186547716","mag":"2186547716"},"language":"en","primary_location":{"id":"mag:2186547716","doi":null,"is_oa":false,"landing_page_url":"https://dm5migu4zj3pb.cloudfront.net/manuscripts/109000/109840/JCI80109840.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017223387","display_name":"William E. Clutter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William E. Clutter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080928184","display_name":"Dennis M. Bier","orcid":"https://orcid.org/0000-0003-4392-4580","observed_orcids":["https://orcid.org/0000-0003-4392-4580"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dennis M. Bier","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4392-4580","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047775356","display_name":"SURESH D. SHAH","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S D Shah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108624170","display_name":"Philip E. Cryer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip E. Cryer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.4140999913215637,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.4140999913215637,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.18870000541210175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.10119999945163727,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9610000252723694},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.7570000290870667},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.9259999990463257},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.7559999823570251},{"id":"https://openalex.org/keywords/blood-lactate","display_name":"blood lactate","score":0.8180000185966492},{"id":"https://openalex.org/keywords/plasma-insulin","display_name":"plasma insulin","score":0.6370000243186951},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.4819999933242798},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.925000011920929},{"id":"https://openalex.org/keywords/alanine","display_name":"alanine","score":0.41999998688697815},{"id":"https://openalex.org/keywords/beta-hydroxybutyrate","display_name":"beta-hydroxybutyrate","score":0.875},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.8697779178619385},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6666699647903442},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6506905555725098},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.6002522110939026},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5882505774497986},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5630171298980713},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.5159114599227905},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.4443252980709076},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42728468775749207},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37811344861984253},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3292750120162964}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2186547716","doi":null,"is_oa":false,"landing_page_url":"https://dm5migu4zj3pb.cloudfront.net/manuscripts/109000/109840/JCI80109840.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1536351550","https://openalex.org/W1579064975","https://openalex.org/W1910934302","https://openalex.org/W2004449713","https://openalex.org/W2007826911","https://openalex.org/W2007862505","https://openalex.org/W2025164069","https://openalex.org/W2025584222","https://openalex.org/W2039242258","https://openalex.org/W2039781946","https://openalex.org/W2052787384","https://openalex.org/W2060219639","https://openalex.org/W2069183459","https://openalex.org/W2072294014","https://openalex.org/W2072733941","https://openalex.org/W2079577855","https://openalex.org/W2083304301","https://openalex.org/W2084247248","https://openalex.org/W2142730388","https://openalex.org/W2146557873","https://openalex.org/W2150416141","https://openalex.org/W2151836253","https://openalex.org/W2153716175","https://openalex.org/W2160126122","https://openalex.org/W2313750540","https://openalex.org/W2341712066","https://openalex.org/W2462168616","https://openalex.org/W2593516720"],"related_works":["https://openalex.org/W2133884882","https://openalex.org/W1866833528","https://openalex.org/W1837088629","https://openalex.org/W2017089847","https://openalex.org/W7128477652","https://openalex.org/W1947878856","https://openalex.org/W2160126122","https://openalex.org/W2057728918","https://openalex.org/W1899872116","https://openalex.org/W2340176183"],"abstract_inverted_index":{"A":[0,5],"B":[1],"S":[2],"T":[3,7],"R":[4],"C":[6],"To":[8],"determine":[9],"the":[10,145,149],"plasma":[11,21,54,90,118,124,126,130,137,152],"epinephrine":[12,22,28,55,64,138,157,177],"thresholds":[13,65],"for":[14,69,76,87,114],"its":[15],"metabolic":[16,23,153],"and":[17,20,37,81,98,107,111,129],"hemodynamic":[18],"actions":[19],"clearance":[24,154],"rates,":[25],"60-min":[26],"intravenous":[27],"infusions":[29,50],"at":[30,175],"nominal":[31],"rates":[32],"of0.1,":[33],"0.5,":[34],"1.0,":[35],"2.5,":[36],"5.0,ug/min":[38],"were":[39,66,132],"performed":[40],"in":[41,52,71,78,89,95,100,117,121],"each":[42],"of":[43,140,156,179],"six":[44],"normal":[45,147],"human":[46],"subjects.":[47],"These":[48],"30":[49],"resulted":[51],"steady-state":[53,176],"concentrations":[56,139,178],"ranging":[57],"from":[58],"24":[59],"to":[60,166],"1,020":[61],"pg/ml.":[62,181],"Plasma":[63],"50-100":[67],"pg/ml":[68,75,113],"increments":[70,77,88],"heart":[72],"rate,":[73],"75-125":[74],"blood":[79,83,103,105,109,122],"glycerol":[80],"systolic":[82],"pressure,":[84,110],"150-200":[85],"pglml":[86],"glucose":[91,96,101],"(the":[92],"resultant":[93],"ofincrements":[94],"production":[97],"decrements":[99,116],"clearance),":[102],"lactate,":[104],"f3-hydroxybutyrate,":[106],"diastolic":[108],">400":[112],"early":[115],"insulin.":[119],"Changes":[120],"alanine,":[123],"glucagon,":[125],"growth":[127],"hormone,":[128],"cortisol":[131],"not":[133],"detected.":[134],"At":[135],"steadystate":[136],"24-74":[141],"pg/ml,":[142],"values":[143],"overlapping":[144],"basal":[146],"range,":[148],"mean":[150],"(\u00b1SE)":[151],"rate":[155],"was":[158],"52\u00b14":[159],"ml":[160,168],"min-l":[161],"kg-l;":[162],"this":[163],"value":[164],"rose":[165],"89\u00b16":[167],"*":[169],"min-'":[170],"kg-'":[171],"(P":[172],"<":[173],"0.01)":[174],"90-1,020":[180],"We":[182],"con":[183]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}