{"id":"https://openalex.org/W2186461996","doi":null,"title":"Mori Fructus Induces Cell Death through ROS-dependent Mitochondrial Apoptotic Pathway in Human Glioma Cells","display_name":"Mori Fructus Induces Cell Death through ROS-dependent Mitochondrial Apoptotic Pathway in Human Glioma Cells","publication_year":2008,"publication_date":"2008-10-01","ids":{"openalex":"https://openalex.org/W2186461996","mag":"2186461996"},"language":"en","primary_location":{"id":"mag:2186461996","doi":null,"is_oa":false,"landing_page_url":"http://www.hantopic.com/kjopp/2205/39.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306496416","display_name":"\ub3d9\uc758\uc0dd\ub9ac\ubcd1\ub9ac\ud559\ud68c\uc9c0","issn_l":"1738-7698","issn":["1738-7698","2288-2529"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\ub3d9\uc758\uc0dd\ub9ac\ubcd1\ub9ac\ud559\ud68c\uc9c0","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045219061","display_name":"Sang Won Jang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sang Won Jang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111942180","display_name":"Ji Cheon Jeong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ji Cheon Jeong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16538424,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"5","first_page":"1322","last_page":"1329"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mulberry-fruit","display_name":"mulberry fruit","score":0.984000027179718},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.7519999742507935},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.972000002861023},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.9359999895095825},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9399999976158142},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.6759999990463257},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.7885254621505737},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.7538967132568359},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7224197387695312},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5819880962371826},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.5658184289932251},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5300378799438477},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4993627071380615},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.49308082461357117},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.45757222175598145},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.43886739015579224},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.4329667091369629},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4254334270954132},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3655044436454773},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3634800910949707},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.15870052576065063},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2186461996","doi":null,"is_oa":false,"landing_page_url":"http://www.hantopic.com/kjopp/2205/39.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306496416","display_name":"\ub3d9\uc758\uc0dd\ub9ac\ubcd1\ub9ac\ud559\ud68c\uc9c0","issn_l":"1738-7698","issn":["1738-7698","2288-2529"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\ub3d9\uc758\uc0dd\ub9ac\ubcd1\ub9ac\ud559\ud68c\uc9c0","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1505511924","https://openalex.org/W1629179716","https://openalex.org/W1661349548","https://openalex.org/W1836073275","https://openalex.org/W1942214720","https://openalex.org/W1975618936","https://openalex.org/W1982077281","https://openalex.org/W1984547206","https://openalex.org/W2002801265","https://openalex.org/W2009127617","https://openalex.org/W2015560109","https://openalex.org/W2017931137","https://openalex.org/W2020563548","https://openalex.org/W2021635663","https://openalex.org/W2025128734","https://openalex.org/W2030003510","https://openalex.org/W2032417513","https://openalex.org/W2041269288","https://openalex.org/W2044321657","https://openalex.org/W2057428268","https://openalex.org/W2062113472","https://openalex.org/W2065743937","https://openalex.org/W2067253455","https://openalex.org/W2071025291","https://openalex.org/W2073700284","https://openalex.org/W2086041616","https://openalex.org/W2090181211","https://openalex.org/W2094998610","https://openalex.org/W2096213285","https://openalex.org/W2096658729","https://openalex.org/W2109531556","https://openalex.org/W2110273291","https://openalex.org/W2113999599","https://openalex.org/W2131878763","https://openalex.org/W2132621820","https://openalex.org/W2134979684","https://openalex.org/W2134979720","https://openalex.org/W2144701362","https://openalex.org/W2147357406","https://openalex.org/W2148126415","https://openalex.org/W2158398965"],"related_works":["https://openalex.org/W1971101696","https://openalex.org/W7214195553","https://openalex.org/W2204513271","https://openalex.org/W2154297461","https://openalex.org/W2471119388","https://openalex.org/W4389007383","https://openalex.org/W7099875273","https://openalex.org/W2061241734","https://openalex.org/W2051535245","https://openalex.org/W2259285985"],"abstract_inverted_index":{"Mulberry":[0],"has":[1,16],"been":[2,17],"reported":[3],"to":[4,37,50],"contain":[5],"wide":[6],"range":[7],"of":[8,22,41,182],"polyphenols":[9],"and":[10,49,61,69,97,124,132,186,195,215],"have":[11],"chemopreventive":[12],"activity.":[13],"However,":[14],"little":[15],"known":[18],"regarding":[19],"the":[20,39,82,133,174,192,219],"effect":[21,40,188],"mulberry":[23,42],"fruits":[24],"on":[25,46],"cell":[26,47,62,119,136,154,222,234],"viability":[27,48,60],"in":[28,55,117,121,151,167,231,240],"human":[29,56,232,241],"glioma":[30,57,233,242],"cells.":[31,58,243],"The":[32,86],"present":[33],"study":[34],"was":[35,79,90,109,138,171,189,204,210],"undertaken":[36],"examine":[38],"fruit":[43],"(Mori":[44],"Fructus)":[45],"determine":[51],"its":[52,187],"underlying":[53],"mechanism":[54],"Cell":[59],"death":[63,120,137,235],"were":[64,101],"estimated":[65,110],"by":[66,103,141,173,191,206,212],"MTT":[67],"assay":[68],"trypanblue":[70],"exclusion":[71],"assay,":[72],"respectively.":[73],"Reactive":[74],"oxygen":[75],"species":[76],"(ROS)":[77],"generation":[78,131,146],"measured":[80,91,102],"using":[81,111],"fluorescence":[83],"probe":[84],"DCFH-DA.":[85],"mitochondrial":[87,183,238],"transmembrane":[88],"potential":[89,185],"with":[92],"DiOC":[93],"6(3).":[94],"Bax":[95,168],"expression":[96],"cytochrome":[98,200],"c":[99,201],"release":[100],"Western":[104,156],"blot":[105,157],"analysis.":[106],"Caspase":[107,208],"activity":[108,209],"colorimetric":[112],"kit.":[113],"Mori":[114,127,134,152,161,178,197,213,220,228],"Fructus":[115,128,162,179,198,214,229],"resulted":[116],"apoptotic":[118],"a":[122,148],"dose-":[123],"time-dependent":[125],"manner.":[126],"increased":[129],"ROS":[130,145],"Fructus-induced":[135,153,221],"also":[139],"prevented":[140,218],"antioxidants,":[142],"suggesting":[143],"that":[144,160,227],"plays":[147],"critical":[149],"role":[150],"death.":[155,223],"analysis":[158],"showed":[159],"treatment":[163],"caused":[164],"an":[165],"increase":[166],"expression,":[169],"which":[170,203],"inhibited":[172,190,205],"antioxidant":[175],"N-acetylcysteine":[176],"(NAC).":[177],"induced":[180,199],"depolarization":[181],"membrane":[184],"antioxidants":[193],"NAC":[194],"catalase.":[196],"release,":[202],"NAC.":[207],"stimulated":[211],"caspase":[216],"inhibitors":[217],"These":[224],"findings":[225],"suggest":[226],"results":[230],"through":[236],"ROS-dependent":[237],"pathway":[239]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}