{"id":"https://openalex.org/W2186387366","doi":null,"title":"Biological evaluation of omega-(dialkylamino)alkyl derivatives of 6H-indolo[2,3-b]quinoline--novel cytotoxic DNA topoisomerase II inhibitors.","display_name":"Biological evaluation of omega-(dialkylamino)alkyl derivatives of 6H-indolo[2,3-b]quinoline--novel cytotoxic DNA topoisomerase II inhibitors.","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W2186387366","mag":"2186387366","pmid":"https://pubmed.ncbi.nlm.nih.gov/16080538"},"language":"en","primary_location":{"id":"pmid:16080538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16080538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024409118","display_name":"Joanna Godlewska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160142","display_name":"Instytut Farmaceutyczny","ror":"https://ror.org/05695qy17","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210160142"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Joanna Godlewska","raw_affiliation_strings":["Pharmaceutical Research Institute, 8 Rydygiera St., 01-783 Warszawa, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Institute, 8 Rydygiera St., 01-783 Warszawa, Poland","institution_ids":["https://openalex.org/I4210160142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081106992","display_name":"Wojciech \u0141uniewski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wojciech Luniewski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044528800","display_name":"Bogdan Zagrodzki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bogdan Zagrodzki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056658473","display_name":"\u0141ukasz Kaczmarek","orcid":"https://orcid.org/0000-0001-8222-8380","observed_orcids":["https://orcid.org/0000-0001-8222-8380"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lukasz Kaczmarek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068459130","display_name":"Aleksandra Bielawska\u2010Pohl","orcid":"https://orcid.org/0000-0002-2757-5571","observed_orcids":["https://orcid.org/0000-0002-2757-5571"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aleksandra Bielawska-Pohl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030793260","display_name":"Danuta Du\u015b","orcid":"https://orcid.org/0000-0003-2429-7315","observed_orcids":["https://orcid.org/0000-0003-2429-7315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danuta Dus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022446752","display_name":"Joanna Wietrzyk","orcid":"https://orcid.org/0000-0003-4980-6606","observed_orcids":["https://orcid.org/0000-0003-4980-6606"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanna Wietrzyk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084508992","display_name":"Adam Opolski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219388962","display_name":"University of Wroc\u0142aw","ror":"https://ror.org/00yae6e25","country_code":"PL","type":"education","lineage":["https://openalex.org/I219388962"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Adam Opolski","raw_affiliation_strings":["University of Wroclaw,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wroclaw,","institution_ids":["https://openalex.org/I219388962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053904178","display_name":"Magdalena E. Siwko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magdalena Siwko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021806327","display_name":"Anna Jaromin","orcid":"https://orcid.org/0000-0002-7921-8007","observed_orcids":["https://orcid.org/0000-0002-7921-8007"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Jaromin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050079774","display_name":"Anna Jakubiak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Jakubiak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017089254","display_name":"Arkadiusz Kozubek","orcid":"https://orcid.org/0000-0002-0033-3863","observed_orcids":["https://orcid.org/0000-0002-0033-3863"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arkadiusz Kozubek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5056533214","display_name":"Wanda Peczynska-Czoch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wanda Peczy\u00f1ska-Czoch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3097,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.50900302,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"25","issue":"4","first_page":"2857","last_page":"68"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topoisomerase-ii-inhibitors","display_name":"topoisomerase II inhibitors","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7689999938011169},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.921999990940094},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7239999771118164},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7689999938011169},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.7900000214576721},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.8880000114440918},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.718999981880188},{"id":"https://openalex.org/keywords/antifungal-activity","display_name":"antifungal activity","score":0.8679999709129333},{"id":"https://openalex.org/keywords/kb-cells","display_name":"KB cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.7048317790031433},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6875031590461731},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.619247555732727},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5287953019142151},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4750808775424957},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44971853494644165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.443661630153656},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.40703922510147095},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3603054881095886},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.346371591091156},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33513855934143066},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14040422439575195},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.12188157439231873},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007624","descriptor_name":"KB Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059005","descriptor_name":"Topoisomerase II Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16080538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16080538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2186387366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16080538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1973428197","https://openalex.org/W1986621896","https://openalex.org/W1989651677","https://openalex.org/W2000036538","https://openalex.org/W2001417887","https://openalex.org/W2010585267","https://openalex.org/W2012905620","https://openalex.org/W2040744087","https://openalex.org/W2044137790","https://openalex.org/W2062281158","https://openalex.org/W2089621956","https://openalex.org/W2102071915","https://openalex.org/W2109689528","https://openalex.org/W2120350646","https://openalex.org/W2152528081","https://openalex.org/W2196199811","https://openalex.org/W2415420089","https://openalex.org/W2606531464","https://openalex.org/W3004986444"],"related_works":["https://openalex.org/W2024741431","https://openalex.org/W2196199811","https://openalex.org/W2415420089","https://openalex.org/W2428961805","https://openalex.org/W1960652777","https://openalex.org/W2020739258","https://openalex.org/W2003498796","https://openalex.org/W1984760649","https://openalex.org/W2128781208","https://openalex.org/W1980416884"],"abstract_inverted_index":{"A":[0],"series":[1],"of":[2,20,41,65,78,131],"novel":[3],"6H-indolo[2,3-b]quinoline":[4],"derivatives,":[5],"substituted":[6],"at":[7,83],"C-2,":[8],"C-9":[9],"or":[10],"N-6":[11],"position":[12],"with":[13],"dialkyl(alkylamino)alkyl":[14],"chains":[15],"differing":[16],"in":[17,29,117,148],"the":[18,51,72,76,132],"number":[19],"methylene":[21],"groups,":[22],"was":[23],"prepared.":[24],"These":[25],"compounds":[26,67,73,142],"were":[27,68,111],"evaluated":[28],"vitro":[30],"for":[31,46],"their":[32,47],"antimicrobial":[33],"and":[34,44,54,60,81,89,110,124,139,156],"cytotoxic":[35,95],"activity":[36,96],"against":[37,97],"several":[38],"cell":[39,52,145],"lines":[40],"different":[42],"origin":[43],"tested":[45,74],"ability":[48],"to":[49,107,113],"influence":[50],"cycle":[53,146],"inhibit":[55],"topoisomerase":[56,158],"II":[57,159],"activity.":[58,160],"Liphophilic":[59],"calf":[61],"thymus":[62],"DNA-binding":[63,154],"properties":[64,155],"these":[66],"also":[69,93],"investigated.":[70],"All":[71],"inhibited":[75,157],"growth":[77],"Gram-positive":[79],"bacteria":[80],"fungi":[82],"MIC":[84],"values":[85,130],"ranging":[86],"between":[87,137],"0.25":[88],"1":[90],"mM.":[91],"They":[92],"showed":[94],"KB":[98],"(human":[99],"cervix":[100],"carcinoma)":[101],"cells":[102,128],"(ID50":[103],"varied":[104],"from":[105],"2.1":[106],"9.0":[108],"microM)":[109],"able":[112],"overcome":[114],"multidrug":[115],"resistance":[116,133],"colorectal":[118],"adenocarcinoma":[119],"LoVo/DX,":[120],"uterine":[121],"sarcoma":[122],"MES-SA/DX5":[123],"promyelocytic":[125],"leukemia":[126,151],"HL-60/MX2":[127],"(the":[129],"index":[134],"RI":[135],"fell":[136],"0.54":[138],"2.4).":[140],"The":[141],"induced":[143],"G2M-phase":[144],"arrest":[147],"Jurkat":[149],"T-cell":[150],"cells,":[152],"revealed":[153]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
