{"id":"https://openalex.org/W2186347264","doi":null,"title":"JNK phosphorylation promotes natural degeneration of cervical endplate chondrocytes by down-regulating expression of ANK.","display_name":"JNK phosphorylation promotes natural degeneration of cervical endplate chondrocytes by down-regulating expression of ANK.","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W2186347264","mag":"2186347264","pmid":"https://pubmed.ncbi.nlm.nih.gov/24065227"},"language":"en","primary_location":{"id":"pmid:24065227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24065227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004778765","display_name":"Xu Hg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]},{"id":"https://openalex.org/I4210167381","display_name":"First Affiliated Hospital of Wannan Medical College","ror":"https://ror.org/05wbpaf14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210167381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H-G Xu","raw_affiliation_strings":["Department of Orthopedic Surgery, Yijishan Hospital, Wannan Medical College, Wuhu, People's Republic of China. pumchxuhg@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Yijishan Hospital, Wannan Medical College, Wuhu, People's Republic of China. pumchxuhg@126.com","institution_ids":["https://openalex.org/I100357981","https://openalex.org/I4210167381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100546243","display_name":"Cheng Jf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J-F Cheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080765180","display_name":"Peng HX","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H-X Peng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003238583","display_name":"Lv K","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Lv","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023011842","display_name":"Huiru Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109838026","display_name":"Liu P","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Zhong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Zhong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5106792867","display_name":"M-Y Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M-Y Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0164,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.7517498,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"17","issue":"17","first_page":"2335","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.6689000129699707,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.6689000129699707,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.3073999881744385,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11518","display_name":"Cervical and Thoracic Myelopathy","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jnk-phosphorylation","display_name":"JNK phosphorylation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/endplate-chondrocytes","display_name":"endplate chondrocytes","score":0.8640000224113464},{"id":"https://openalex.org/keywords/intervertebral-disc-degeneration","display_name":"intervertebral disc degeneration","score":0.878000020980835},{"id":"https://openalex.org/keywords/ank","display_name":"ANK","score":0.7289999723434448},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.847000002861023},{"id":"https://openalex.org/keywords/type-ii-collagen","display_name":"type II collagen","score":0.878000020980835},{"id":"https://openalex.org/keywords/aggrecan","display_name":"aggrecan","score":1.0},{"id":"https://openalex.org/keywords/chondrocyte-proliferation","display_name":"chondrocyte proliferation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/sp600125","display_name":"SP600125","score":0.9110000133514404},{"id":"https://openalex.org/keywords/chondrocyte-senescence","display_name":"chondrocyte senescence","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C197534660","wikidata":"https://www.wikidata.org/wiki/Q21121862","display_name":"Aggrecan","level":5,"score":0.8093596696853638},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.739962637424469},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.681239664554596},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6271364688873291},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6226569414138794},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5904206037521362},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5261760950088501},{"id":"https://openalex.org/C2781013607","wikidata":"https://www.wikidata.org/wiki/Q14877666","display_name":"Type II collagen","level":3,"score":0.41367006301879883},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4034649431705475},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2743039131164551},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2398930788040161},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23709934949874878},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.2291889786720276},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16285941004753113},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09653204679489136},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.0},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000873","descriptor_name":"Anthracenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002574","descriptor_name":"Cervical Vertebrae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002574","descriptor_name":"Cervical Vertebrae","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D024043","descriptor_name":"Collagen Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D028061","descriptor_name":"Phosphate Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053674","descriptor_name":"Aggrecans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24065227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24065227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},{"id":"mag:2186347264","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24065227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1924763086","https://openalex.org/W1963629215","https://openalex.org/W1966268963","https://openalex.org/W1966292479","https://openalex.org/W1970341919","https://openalex.org/W2000413455","https://openalex.org/W2000476522","https://openalex.org/W2002078337","https://openalex.org/W2005298420","https://openalex.org/W2008390728","https://openalex.org/W2017384250","https://openalex.org/W2019213708","https://openalex.org/W2020405841","https://openalex.org/W2020931266","https://openalex.org/W2021904780","https://openalex.org/W2025386702","https://openalex.org/W2027601065","https://openalex.org/W2031543074","https://openalex.org/W2045822231","https://openalex.org/W2047823550","https://openalex.org/W2048256252","https://openalex.org/W2050273631","https://openalex.org/W2058645214","https://openalex.org/W2058667888","https://openalex.org/W2065977480","https://openalex.org/W2069221911","https://openalex.org/W2072249641","https://openalex.org/W2074098537","https://openalex.org/W2076485183","https://openalex.org/W2081264270","https://openalex.org/W2091464294","https://openalex.org/W2093030407","https://openalex.org/W2096931514","https://openalex.org/W2098537129","https://openalex.org/W2111763891","https://openalex.org/W2128387725","https://openalex.org/W2152983876","https://openalex.org/W2407196167","https://openalex.org/W2416745097"],"related_works":["https://openalex.org/W2409105536","https://openalex.org/W2362644546","https://openalex.org/W2416745097","https://openalex.org/W2275972856","https://openalex.org/W2496523179","https://openalex.org/W2387108428","https://openalex.org/W2430391886","https://openalex.org/W2395224169","https://openalex.org/W2761596905","https://openalex.org/W2397468742"],"abstract_inverted_index":{"BACKGROUND:":[0],"Endplate":[1],"degeneration":[2,6,47,67,169,239],"leads":[3],"to":[4,50,91,159],"accelerated":[5],"of":[7,13,42,57,68,75,111,119,163,170,177,185,201,216,222,235,240],"the":[8,40,46,148,155,161,164,217],"intervertebral":[9],"disc.":[10],"The":[11,174],"importance":[12],"endplate":[14,69,171,178,242],"chondrocytes":[15,25,88,179],"in":[16,24,45,80,154],"this":[17,81],"process":[18,48],"is":[19],"unclear.":[20],"Many":[21],"cellular":[22],"processes":[23],"are":[26],"controlled":[27],"by":[28,135,211,245],"activated":[29],"c-Jun":[30],"N-terminal":[31],"kinases":[32],"(JNK)":[33],"and":[34,59,63,93,108,126,131,139,189,209,227,229],"protein":[35,78],"kinase":[36],"B":[37],"(AKT).":[38],"However,":[39],"involvement":[41,74],"their":[43,64],"pathways":[44,62],"needs":[49],"be":[51],"elucidated.":[52],"AIM:":[53],"To":[54],"study":[55],"activation":[56],"JNK":[58,125,149,165,218,236],"AKT":[60,130],"signaling":[61],"significance":[65],"for":[66],"chondrocytes,":[70,243],"as":[71,73],"well":[72],"progressive":[76],"ankylosis":[77],"(ANK)":[79],"process.":[82],"MATERIALS":[83],"AND":[84],"METHODS:":[85],"Rat":[86],"primary":[87],"were":[89,115,133,151,191],"grown":[90],"confluence":[92],"subcultured":[94],"until":[95],"passage":[96,156],"4.":[97],"Morphological":[98],"appearances":[99],"(microscope,":[100],"hematoxylin":[101],"&":[102],"eosin":[103],"staining,":[104],"toluidine":[105],"blue":[106],"staining)":[107],"proliferation":[109,231],"rates":[110],"cells":[112,158,195],"(MTT":[113],"test)":[114],"observed.":[116],"Further,":[117],"levels":[118],"type":[120,186,223],"II":[121,187,224],"collagen,":[122,225],"aggrecan,":[123],"phosphorylated":[124],"AKT,":[127,205],"total":[128],"JNK,":[129,202],"ANK":[132,213,228,247],"evaluated":[134],"qPCR,":[136],"flow":[137],"cytometry":[138],"Western":[140],"blot":[141],"assays.":[142],"Furthermore,":[143,199],"inhibition":[144],"experiments":[145],"with":[146,194],"SP600125,":[147],"inhibitor,":[150],"carried":[152],"out":[153],"4":[157],"assess":[160],"effects":[162],"pathway":[166,219],"on":[167],"natural":[168,238],"chondrocytes.":[172],"RESULTS:":[173],"proliferative":[175],"speed":[176],"progressively":[180],"decreased":[181,193],"during":[182],"passaging.":[183],"Expressions":[184],"collagen":[188],"aggrecan":[190,226],"significantly":[192,207],"at":[196],"higher":[197],"passages.":[198],"phosphorylation":[200],"but":[203],"not":[204],"was":[206],"up-regulated":[208],"accompanied":[210],"reduced":[212],"expression.":[214,248],"Inhibition":[215],"increased":[220],"expression":[221],"facilitated":[230],"rates.":[232],"CONCLUSIONS:":[233],"Phosphorylation":[234],"promotes":[237],"cervical":[241],"likely":[244],"down-regulating":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
