{"id":"https://openalex.org/W2186257539","doi":null,"title":"Linear Mixed Models in Clinical Trials using PROC MIXED","display_name":"Linear Mixed Models in Clinical Trials using PROC MIXED","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2186257539","mag":"2186257539"},"language":"en","primary_location":{"id":"mag:2186257539","doi":null,"is_oa":false,"landing_page_url":"https://www.lexjansen.com/pharmasug/2010/SP/SP07.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047014482","display_name":"Danyang Bing","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Danyang Bing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5047014482"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.20464602,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.07479999959468842,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13820","display_name":"SAS software applications and methods","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1712","display_name":"Software"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/linear-mixed-models","display_name":"linear mixed models","score":1.0},{"id":"https://openalex.org/keywords/proc-mixed","display_name":"PROC MIXED","score":0.9049999713897705},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.9319999814033508},{"id":"https://openalex.org/keywords/randomized-complete-block-design","display_name":"randomized complete block design","score":0.9900000095367432},{"id":"https://openalex.org/keywords/split-plot-design","display_name":"split-plot design","score":0.8550000190734863},{"id":"https://openalex.org/keywords/crossover-design","display_name":"crossover design","score":0.8379999995231628},{"id":"https://openalex.org/keywords/repeated-measures-analysis","display_name":"repeated measures analysis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/sas-software","display_name":"SAS software","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C16012445","wikidata":"https://www.wikidata.org/wiki/Q1501135","display_name":"Mixed model","level":2,"score":0.8777322173118591},{"id":"https://openalex.org/C153720581","wikidata":"https://www.wikidata.org/wiki/Q5532490","display_name":"Generalized linear mixed model","level":2,"score":0.864639163017273},{"id":"https://openalex.org/C53059260","wikidata":"https://www.wikidata.org/wiki/Q374758","display_name":"Multilevel model","level":2,"score":0.6124463677406311},{"id":"https://openalex.org/C163175372","wikidata":"https://www.wikidata.org/wiki/Q3339222","display_name":"Linear model","level":2,"score":0.5621412992477417},{"id":"https://openalex.org/C41587187","wikidata":"https://www.wikidata.org/wiki/Q1501882","display_name":"Generalized linear model","level":2,"score":0.43259096145629883},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.42469415068626404},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3793911933898926},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3631829023361206}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2186257539","doi":null,"is_oa":false,"landing_page_url":"https://www.lexjansen.com/pharmasug/2010/SP/SP07.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W114854541","https://openalex.org/W643529837","https://openalex.org/W1555095646","https://openalex.org/W2118840867","https://openalex.org/W2134224174","https://openalex.org/W2473850659"],"related_works":["https://openalex.org/W7101025097","https://openalex.org/W2073453589","https://openalex.org/W166701918","https://openalex.org/W7133034731","https://openalex.org/W7098997253","https://openalex.org/W2365842831","https://openalex.org/W2376271052","https://openalex.org/W2550925958","https://openalex.org/W7098777791","https://openalex.org/W1915630050"],"abstract_inverted_index":{"This":[0],"paper":[1],"mainly":[2],"illustrates":[3],"how":[4],"to":[5,9,45],"use":[6],"PROC":[7,50,53,66],"MIXED":[8,54,67],"fit":[10],"linear":[11,24,59],"mixed":[12,25,34,60],"models":[13],"in":[14,55,68],"clinical":[15,72],"trials.":[16],"We":[17,27],"first":[18],"introduce":[19],"the":[20,29,33,47,58],"statistical":[21],"background":[22],"of":[23,65],"models.":[26,61,85],"explore":[28],"situations":[30],"under":[31],"which":[32],"effects":[35],"are":[36],"identified.":[37],"A":[38],"randomized":[39],"complete":[40],"block":[41],"design":[42],"is":[43],"used":[44],"explain":[46],"difference":[48],"between":[49],"GLM":[51],"and":[52,82],"dealing":[56],"with":[57],"Examples":[62],"include":[63],"applications":[64],"four":[69],"commonly":[70],"seen":[71],"trials":[73],"utilizing":[74],"splitplot":[75],"designs,":[76,78],"cross-over":[77],"repeated":[79],"measures":[80],"analysis":[81],"multilevel":[83],"hierarchical":[84]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}