{"id":"https://openalex.org/W2186227228","doi":null,"title":"Fibronectin Enhances Carfilzomib Mediated Cell Death","display_name":"Fibronectin Enhances Carfilzomib Mediated Cell Death","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2186227228","mag":"2186227228"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/579327","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/579327","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086721812","display_name":"Paulina Joanna Ramos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Paulina Joanna Ramos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5086721812"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.8700000047683716},{"id":"https://openalex.org/keywords/carfilzomib","display_name":"carfilzomib","score":0.9919999837875366},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7760000228881836},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7570000290870667},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.8709999918937683},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.9340000152587891},{"id":"https://openalex.org/keywords/caspase-independent-cell-death","display_name":"caspase-independent cell death","score":0.8790000081062317},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cell-adhesion-mediated-drug-resistance","display_name":"cell adhesion-mediated drug resistance","score":0.7300000190734863},{"id":"https://openalex.org/keywords/mm-1s","display_name":"MM.1S","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C2780108899","wikidata":"https://www.wikidata.org/wiki/Q15366934","display_name":"Carfilzomib","level":4,"score":0.9374570846557617},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.547801673412323},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.4855760931968689},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37151288986206055},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.36496320366859436},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33935582637786865},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33424344658851624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2930256128311157},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.2397289276123047},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.17476528882980347},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.1637992262840271},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15731653571128845}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/579327","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/579327","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis"},{"id":"mag:2186227228","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/handle/10150/579327","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1528751727","https://openalex.org/W1828227463","https://openalex.org/W1990518937","https://openalex.org/W1999620129","https://openalex.org/W2013294222","https://openalex.org/W2041997066","https://openalex.org/W2083365324","https://openalex.org/W2088081193","https://openalex.org/W2137878070","https://openalex.org/W2154343997","https://openalex.org/W2303045765","https://openalex.org/W2330253244"],"related_works":["https://openalex.org/W638633404","https://openalex.org/W2586391265","https://openalex.org/W1528751727","https://openalex.org/W2509618967","https://openalex.org/W2050229050","https://openalex.org/W1995892234","https://openalex.org/W6982654788","https://openalex.org/W1723444490","https://openalex.org/W1733885106","https://openalex.org/W3214451839"],"abstract_inverted_index":{"Cell":[0],"Adhesion":[1],"Mediated":[2],"Drug":[3],"Resistance":[4],"(CAM-DR)":[5],"is":[6,30,94,131],"a":[7,98],"factor":[8],"in":[9,17,26,42,72,88,103,124,127,134,142,171],"Multiple":[10],"Myeloma":[11],"(MM)":[12],"drug":[13,27],"resistance.":[14,28],"Despite":[15],"advances":[16],"treatment,":[18],"multiple":[19],"myeloma":[20,43,55,85,104,125],"remains":[21],"incurable":[22],"and":[23,53,83,194],"often":[24],"results":[25],"It":[29],"known":[31],"that":[32,48,117,138,161,180],"cell":[33,60,86,122,198],"adhesion":[34,164],"to":[35,57,74,107,111,145,153,165,175],"fibronectin":[36,108,146,166],"via":[37],"integrin":[38],"\u03b21":[39,162],"confers":[40],"survival":[41,92,192],"cells.":[44],"We":[45,96,136,178],"show":[46],"here":[47],"adherence":[49],"of":[50,101,183],"the":[51,90,139,159,189],"NCI-H929":[52],"MM.1S":[54],"cells":[56,105,126,143,173],"fibronectin,":[58],"promotes":[59],"death":[61,102,123],"when":[62,109],"treated":[63],"with":[64],"proteasome":[65,186],"inhibitor":[66],"Carfilzomib":[67,129],"(Kyprolis).":[68],"These":[69,156],"data":[70,157],"are":[71],"contrast":[73],"other":[75],"cytotoxic":[76],"drugs,":[77],"such":[78],"as":[79],"melphalan":[80],"or":[81],"doxorubicin,":[82],"different":[84],"lines":[87],"which":[89],"CAM-DR":[91,176],"phenotype":[93],"expressed.":[95],"found":[97],"significant":[99],"amount":[100],"adhered":[106,144],"exposed":[110],"carfilzomib.":[112],"In":[113],"addition,":[114],"we":[115],"demonstrate":[116],"pan-caspase":[118],"inhibitor,":[119],"Q-VD-OPH,":[120],"inhibits":[121],"suspension.":[128,135],"cytotoxicity":[130,141],"caspase":[132,149,196],"dependent":[133],"propose":[137,179],"increased":[140],"may":[147],"be":[148],"independent,":[150],"perhaps":[151],"due":[152],"failed":[154],"autophagy.":[155],"support":[158],"hypothesis":[160],"mediated":[163],"induces":[167],"an":[168],"autophagic":[169],"response":[170,193],"MM":[172],"contributing":[174],"phenotype.":[177],"further":[181],"induction":[182],"autophagy":[184],"by":[185],"inhibitors":[187],"exceeds":[188],"adaptive":[190],"threshold":[191],"initiates":[195],"independent":[197],"death.":[199]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
