{"id":"https://openalex.org/W2186217899","doi":"https://doi.org/10.1242/dev.105.1.119","title":"Periodic segmental anomalies induced by heat shock in the chick embryo are associated with the cell cycle","display_name":"Periodic segmental anomalies induced by heat shock in the chick embryo are associated with the cell cycle","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2186217899","doi":"https://doi.org/10.1242/dev.105.1.119","mag":"2186217899","pmid":"https://pubmed.ncbi.nlm.nih.gov/2806112"},"language":"en","primary_location":{"id":"doi:10.1242/dev.105.1.119","doi":"https://doi.org/10.1242/dev.105.1.119","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.105.1.119","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109942249","display_name":"Dennis R. N. Primmett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. R. N. Primmett","raw_affiliation_strings":["1 Department of Human Anatomy, South Parks Road, Oxford OX1 3QX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Human Anatomy, South Parks Road, Oxford OX1 3QX, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034764567","display_name":"Wendie E. Norris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W. E. Norris","raw_affiliation_strings":["1 Department of Human Anatomy, South Parks Road, Oxford OX1 3QX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Human Anatomy, South Parks Road, Oxford OX1 3QX, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014780051","display_name":"Geoffrey J. Carlson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G. J. Carlson","raw_affiliation_strings":["1 Department of Human Anatomy, South Parks Road, Oxford OX1 3QX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Human Anatomy, South Parks Road, Oxford OX1 3QX, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042802022","display_name":"Roger J. Keynes","orcid":"https://orcid.org/0000-0002-1557-7684","observed_orcids":["https://orcid.org/0000-0002-1557-7684"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. J. Keynes","raw_affiliation_strings":["2 Department of Anatomy, Downing Street, Cambridge CB2 3DY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Department of Anatomy, Downing Street, Cambridge CB2 3DY, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041431345","display_name":"Claudio D. Stern","orcid":"https://orcid.org/0000-0002-9907-889X","observed_orcids":["https://orcid.org/0000-0002-9907-889X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. D. Stern","raw_affiliation_strings":["1 Department of Human Anatomy, South Parks Road, Oxford OX1 3QX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Human Anatomy, South Parks Road, Oxford OX1 3QX, UK","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9925,"has_fulltext":false,"cited_by_count":169,"citation_normalized_percentile":{"value":0.8808904,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"105","issue":"1","first_page":"119","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somite-segmentation","display_name":"somite segmentation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.6809999942779541},{"id":"https://openalex.org/keywords/heat-shock","display_name":"heat shock","score":0.7850000262260437},{"id":"https://openalex.org/keywords/chick-embryo","display_name":"chick embryo","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cell-cycle-synchronization","display_name":"cell cycle synchronization","score":0.8880000114440918},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cell-cycle-inhibitors","display_name":"cell cycle inhibitors","score":0.6029999852180481},{"id":"https://openalex.org/keywords/cell-fate-specification","display_name":"cell fate specification","score":0.33399999141693115}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.888312578201294},{"id":"https://openalex.org/C2779018604","wikidata":"https://www.wikidata.org/wiki/Q1427600","display_name":"Somite","level":4,"score":0.8001586198806763},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.716428279876709},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.7092807292938232},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.6325289011001587},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6284136176109314},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.45472943782806396},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.4541950821876526},{"id":"https://openalex.org/C137984847","wikidata":"https://www.wikidata.org/wiki/Q1621258","display_name":"Heat shock","level":4,"score":0.41494494676589966},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41360414028167725},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3958514928817749},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23877733945846558},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2248363196849823},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.2134932577610016},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05752924084663391},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002970","descriptor_name":"Cleavage Stage, Ovum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1242/dev.105.1.119","doi":"https://doi.org/10.1242/dev.105.1.119","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.105.1.119","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:2806112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2806112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1366811","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1366811/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DEVELOPMENT , 105 (1) pp. 119-130. (1989)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W149327803","https://openalex.org/W153132690","https://openalex.org/W191290898","https://openalex.org/W191342842","https://openalex.org/W1043912065","https://openalex.org/W1589329776","https://openalex.org/W1592141163","https://openalex.org/W1601249389","https://openalex.org/W1819473060","https://openalex.org/W1860601694","https://openalex.org/W1947794129","https://openalex.org/W1956965851","https://openalex.org/W1984713273","https://openalex.org/W1989946857","https://openalex.org/W2010021658","https://openalex.org/W2031606976","https://openalex.org/W2032448671","https://openalex.org/W2072466974","https://openalex.org/W2077070449","https://openalex.org/W2080269085","https://openalex.org/W2081468251","https://openalex.org/W2087803718","https://openalex.org/W2090159978","https://openalex.org/W2091445050","https://openalex.org/W2092713432","https://openalex.org/W2094822263","https://openalex.org/W2100837269","https://openalex.org/W2131074060","https://openalex.org/W2140034535","https://openalex.org/W2150553522","https://openalex.org/W2159681773","https://openalex.org/W2186005865","https://openalex.org/W2343816916","https://openalex.org/W2346308297","https://openalex.org/W2385672755","https://openalex.org/W2502780592","https://openalex.org/W2593269239","https://openalex.org/W4236516883","https://openalex.org/W4250029638"],"related_works":["https://openalex.org/W2343243839","https://openalex.org/W1860601694","https://openalex.org/W2047307058","https://openalex.org/W2343816916","https://openalex.org/W2138263470","https://openalex.org/W2994519566","https://openalex.org/W2184417446","https://openalex.org/W2091445050","https://openalex.org/W2034003853","https://openalex.org/W2398869870"],"abstract_inverted_index":{"This":[0],"study":[1],"provides":[2],"evidence":[3],"that":[4,174,209,220],"cells":[5,34,219],"destined":[6],"to":[7,57,86,97,101,106,127,164,193,196],"segment":[8,222],"together":[9],"into":[10],"somites":[11,73,88,93],"have":[12,20],"a":[13,52,80],"degree":[14],"of":[15,24,35,47,51,54,114,133,141,148,160,169,182,188],"cell":[16,26,60,116,198,211],"division":[17,27,61,212],"synchrony.":[18],"We":[19],"measured":[21],"the":[22,25,36,59,90,99,112,115,142,146,155,158,165,180,197,210],"duration":[23,113],"cycle":[28,62,117,213],"in":[29,77,120,205,217],"somite":[30,103],"and":[31,139],"segmental":[32,66,183,190],"plate":[33],"chick":[37,135],"embryo":[38],"as":[39,118],"9.5":[40],"h":[41,96],"using":[42],"[3H]thymidine":[43],"pulse-":[44],"and-chase.":[45],"Treatment":[46],"embryos":[48],"with":[49],"any":[50],"variety":[53],"inhibitors":[55],"known":[56],"affect":[58],"causes":[63],"discrete":[64],"periodic":[65,189],"anomalies:":[67],"these":[68,121,161],"anomalies":[69,124,170,184,191],"appear":[70],"about":[71,107],"6-7":[72],"after":[74,89,130],"treatment":[75],"and,":[76],"some":[78,140],"cases,":[79],"second":[81],"anomaly":[82],"is":[83,111,203,214],"observed":[84],"6":[85],"7":[87],"first.":[91],"Since":[92],"take":[94],"1.5":[95],"form,":[98],"6-":[100],"7-":[102],"interval":[104],"corresponds":[105],"9-10":[108],"h,":[109],"which":[110,206],"determined":[119],"experiments.":[122],"The":[123,186],"are":[125,176],"similar":[126],"those":[128],"seen":[129],"heat":[131],"shock":[132,138],"2-day":[134],"embryos.":[136],"Heat":[137],"other":[143],"treatments":[144],"induce":[145],"expression":[147,156],"heat-shock":[149],"proteins":[150,162],"(hsp);":[151],"however,":[152],"since":[153],"neither":[154],"nor":[157],"distribution":[159,168],"relate":[163],"presence":[166],"or":[167],"seen,":[171],"we":[172,207],"conclude":[173],"hsps":[175],"not":[177],"responsible":[178],"for":[179],"pattern":[181],"observed.":[185],"production":[187],"appears":[192],"be":[194],"linked":[195],"cycle.":[199],"A":[200],"simple":[201],"model":[202],"proposed,":[204],"suggest":[208],"involved":[215],"directly":[216],"gating":[218],"will":[221],"together.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}