{"id":"https://openalex.org/W2186160472","doi":null,"title":"Characterization of Calcium-activated Potassium and Nonspecific Cation Currents","display_name":"Characterization of Calcium-activated Potassium and Nonspecific Cation Currents","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2186160472","mag":"2186160472"},"language":"en","primary_location":{"id":"mag:2186160472","doi":null,"is_oa":false,"landing_page_url":"https://mcb.berkeley.edu/labs/zucker/PDFs/Lando_JGenPhysiol93,1017.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052532773","display_name":"Luca Land","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luca Land","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046481259","display_name":"Robert S. Zucker","orcid":"https://orcid.org/0000-0003-1068-2343","observed_orcids":["https://orcid.org/0000-0003-1068-2343"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert S. Zucker","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1068-2343","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1078,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.30795414,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-activated-potassium-current","display_name":"calcium-activated potassium current","score":0.9890000224113464},{"id":"https://openalex.org/keywords/arsenazo-iii","display_name":"arsenazo III","score":0.7490000128746033},{"id":"https://openalex.org/keywords/na-ca-exchange","display_name":"Na-Ca exchange","score":0.8009999990463257},{"id":"https://openalex.org/keywords/calcium-efflux","display_name":"calcium efflux","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.767238974571228},{"id":"https://openalex.org/C98015330","wikidata":"https://www.wikidata.org/wiki/Q907315","display_name":"Absorbance","level":2,"score":0.6250467896461487},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5886967778205872},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.5006988048553467},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.4827263057231903},{"id":"https://openalex.org/C151552171","wikidata":"https://www.wikidata.org/wiki/Q163373","display_name":"Pipette","level":2,"score":0.43594539165496826},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34117555618286133},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2497376799583435},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2186160472","doi":null,"is_oa":false,"landing_page_url":"https://mcb.berkeley.edu/labs/zucker/PDFs/Lando_JGenPhysiol93,1017.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W59707374","https://openalex.org/W654397753","https://openalex.org/W1591593323","https://openalex.org/W1876408798","https://openalex.org/W1963556817","https://openalex.org/W1963843218","https://openalex.org/W1965021455","https://openalex.org/W1971894280","https://openalex.org/W1977245451","https://openalex.org/W1979628218","https://openalex.org/W1980733347","https://openalex.org/W1982212676","https://openalex.org/W1985377930","https://openalex.org/W1985940938","https://openalex.org/W1989711279","https://openalex.org/W1989712467","https://openalex.org/W1992265032","https://openalex.org/W1995088484","https://openalex.org/W1996864070","https://openalex.org/W2004079359","https://openalex.org/W2004919934","https://openalex.org/W2009383361","https://openalex.org/W2010060270","https://openalex.org/W2019143922","https://openalex.org/W2022989709","https://openalex.org/W2033115595","https://openalex.org/W2033817793","https://openalex.org/W2037690134","https://openalex.org/W2037948838","https://openalex.org/W2038107991","https://openalex.org/W2040970293","https://openalex.org/W2041607744","https://openalex.org/W2043203604","https://openalex.org/W2050322740","https://openalex.org/W2052733759","https://openalex.org/W2058333657","https://openalex.org/W2066309047","https://openalex.org/W2068283287","https://openalex.org/W2070119115","https://openalex.org/W2073586079","https://openalex.org/W2074205533","https://openalex.org/W2075310196","https://openalex.org/W2076809828","https://openalex.org/W2078470986","https://openalex.org/W2078761017","https://openalex.org/W2081623770","https://openalex.org/W2088372173","https://openalex.org/W2101781927","https://openalex.org/W2101966660","https://openalex.org/W2103928042","https://openalex.org/W2139714561","https://openalex.org/W2142639496","https://openalex.org/W2150883758","https://openalex.org/W2163594831","https://openalex.org/W2163868617","https://openalex.org/W2177672697","https://openalex.org/W2179038293","https://openalex.org/W2305274740","https://openalex.org/W2497951911"],"related_works":["https://openalex.org/W2118175956","https://openalex.org/W7096766629","https://openalex.org/W2069258252","https://openalex.org/W33783160","https://openalex.org/W2111822563","https://openalex.org/W2133959871","https://openalex.org/W2021059007","https://openalex.org/W1980159010","https://openalex.org/W2431338714","https://openalex.org/W2994043359"],"abstract_inverted_index":{"We":[0,282],"have":[1,283],"studied":[2],"calcium-activated":[3,116,240],"potassium":[4],"current,":[5,12],"Ivan),":[6],"and":[7,42,52,85,94,132,158,186,204,252,341],"cal-":[8],"cium-activated":[9],"nonspecific":[10],"cation":[11],"Insr":[13],"in":[14,58,73,105,123,150,168,190],"Aplysia":[15],"bursting":[16],"pacemaker":[17],"neurons,":[18],"using":[19],"photolysis":[20,72],"of":[21,36,127,143,202,210,222,239,246,264,295,299,319,321],"a":[22,173,184,244,273,290,304,310,317,352],"calcium":[31],"chelator":[24],"(nitr-5":[25],"or":[26],"nitr-7)":[27],"to":[28,48,64,125,153,183,188,207,235,272],"release":[29],"caged":[30],"intracellularly.":[32],"A":[33],"computer":[34],"model":[35,76,194,318],"nitr":[37,71,91,205],"photolysis,":[38],"multiple":[39],"buffer":[40],"equilibration,":[41],"active":[43,336],"extrusion":[45,337],"was":[46],"developed":[47],"predict":[49],"volume-aver-":[50],"age":[51],"front-surface":[53],"concentration":[55,67,103,141],"transients.":[56],"Changes":[57],"arsenazo":[59,164],"III":[60,110,165],"absorbance":[61,166],"were":[62,118],"used":[63],"measure":[65],"changes":[68,167],"caused":[69,81],"by":[70,82,301,316,338],"microcuvettes.":[74],"Our":[75,193],"predicted":[77,101,315],"the":[78,100,163,208,211,214,237,277,296,325,333],"increments":[80],"successive":[83],"flashes,":[84],"their":[86],"dependence":[87],"on":[88],"loading,":[90],"concentra-":[92],"tion,":[93],"light":[95],"intensity.":[96,129],"Flashes":[97],"also":[98,171],"triggered":[99],"jumps":[104,142],"neurons":[106,151],"filled":[107],"with":[108,335],"nitr-arsenazo":[109],"mixtures.":[111],"In":[112],"physiological":[113],"experi-":[114],"ments,":[115],"currents":[117],"recorded":[119],"under":[120],"voltage":[121,278],"clamp":[122],"response":[124],"flashes":[126,155],"different":[128,247,274],"Both":[130],"I~c~)":[131],"Ins~c~":[133],"~":[134],"depended":[135],"linearly":[136],"without":[137],"saturation":[138],"upon":[139],"0.1-20":[144],"#M.":[145],"Peak":[146],"membrane":[147,241,248,327],"cur-":[148],"rents":[149],"exposed":[152],"repeated":[154],"first":[156],"increased":[157],"then":[159],"declined":[160],"much":[161],"like":[162],"vitro,":[169],"which":[170],"indicates":[172],"first-":[174],"order":[175],"activation.":[177],"Each":[178],"flash-evoked":[179],"current":[180],"rose":[181],"rapidly":[182],"peak":[185],"decayed":[187,254],"half":[189],"3-12":[191],"s.":[192],"mimicked":[195],"this":[196],"behavior":[197],"when":[198,276],"it":[199,330],"included":[200],"diffusion":[201,320],"perpendicular":[206],"surface":[209,328,339],"neuron":[212],"facing":[213],"flashlamp.":[215],"Na/Ca":[216],"exchange":[217],"extruding":[218],"about":[219],"1":[220],"pmol":[221],"per":[224,228,230],"square":[225],"centi-":[226],"meter":[227],"second":[229],"micromolar":[231],"free":[232],"appeared":[234],"speed":[236],"decline":[238],"currents.":[242],"Over":[243],"range":[245],"poten-":[249],"tials,":[250],"I~c,~":[251],"Ins(c,~":[253],"at":[255,309],"similar":[256,259],"rates,":[257],"indicating":[258],"stoichiome-":[261],"tries":[262],"independent":[263],"voltage.":[265],"Ir~c,),":[266],"but":[267],"not":[268],"INs~),":[269],"relaxes":[270],"exponentially":[271],"level":[275],"is":[279,313],"suddenly":[280],"changed.":[281],"estimated":[284],"voltage-":[285],"dependent":[286],"rate":[287,311],"constants":[288],"for":[289],"one-step":[291],"first-order":[292],"reaction":[293],"scheme":[294],"activa-":[297],"tion":[298],"Ir~c.,)":[300],"calcium.":[302],"After":[303],"depolarizing":[305],"pulse,":[306],"INs(c~":[307],"decays":[308,346],"that":[312],"well":[314],"away":[323],"from":[324],"inner":[326],"after":[329,351],"has":[331],"entered":[332],"cell,":[334],"pumps":[340],"uptake":[342],"into":[343],"organelles.":[344],"Ivac~":[345],"somewhat":[347],"faster":[348],"than":[349],"INsr":[350],"depolariza-":[353]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}