{"id":"https://openalex.org/W2186115486","doi":"https://doi.org/10.3967/bes2014.007","title":"Cyanidin-3-O-galactoside and blueberry extracts supplementation improves spatial memory and regulates hippocampal ERK expression in senescence-accelerated mice.","display_name":"Cyanidin-3-O-galactoside and blueberry extracts supplementation improves spatial memory and regulates hippocampal ERK expression in senescence-accelerated mice.","publication_year":2014,"publication_date":"2014-03-01","ids":{"openalex":"https://openalex.org/W2186115486","doi":"https://doi.org/10.3967/bes2014.007","mag":"2186115486","pmid":"https://pubmed.ncbi.nlm.nih.gov/24709099"},"language":"en","primary_location":{"id":"pmid:24709099","doi":"https://doi.org/10.3967/bes2014.007","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24709099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical and environmental sciences : BES","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100679758","display_name":"Long Tan","orcid":"https://orcid.org/0000-0002-8793-4476","observed_orcids":["https://orcid.org/0000-0002-8793-4476"]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Long Tan","raw_affiliation_strings":["Department of Nutrition and Food Security, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Tianjin 300070, China; Department of Nutrition and Food Science, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, 1 Dali Road, Tianjin 300050, China","Academy of Military Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Security, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Tianjin 300070, China; Department of Nutrition and Food Science, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, 1 Dali Road, Tianjin 300050, China","institution_ids":["https://openalex.org/I2802541053","https://openalex.org/I5740404"]},{"raw_affiliation_string":"Academy of Military Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033212026","display_name":"Hong Peng Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Peng Yang","raw_affiliation_strings":["Tianjin Agricultural College, 22 Jinjing Highway, Tianjin 300384, China; Department of Nutrition and Food Science, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, 1 Dali Road, Tianjin 300050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Agricultural College, 22 Jinjing Highway, Tianjin 300384, China; Department of Nutrition and Food Science, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, 1 Dali Road, Tianjin 300050, China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102354197","display_name":"Wei Pang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Pang","raw_affiliation_strings":["Department of Nutrition and Food Science, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, 1 Dali Road, Tianjin 300050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Science, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, 1 Dali Road, Tianjin 300050, China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020555698","display_name":"Hao Lu","orcid":"https://orcid.org/0000-0002-7742-0316","observed_orcids":["https://orcid.org/0000-0002-7742-0316"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Hao Lu","raw_affiliation_strings":["Department of Nutrition and Food Science, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, 1 Dali Road, Tianjin 300050, China; Center for Disease Control and Prevention, PLA Chengdu Military Area Command, Chengdu 610021, China","Centers for Disease Control and Prevention, Atlanta, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Science, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, 1 Dali Road, Tianjin 300050, China; Center for Disease Control and Prevention, PLA Chengdu Military Area Command, Chengdu 610021, China","institution_ids":["https://openalex.org/I2802541053"]},{"raw_affiliation_string":"Centers for Disease Control and Prevention, Atlanta, United States","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044741298","display_name":"Yan Dan Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Dan Hu","raw_affiliation_strings":["Department of Nutrition and Food Science, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, 1 Dali Road, Tianjin 300050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Science, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, 1 Dali Road, Tianjin 300050, China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336971","display_name":"Jing Li","orcid":"https://orcid.org/0000-0002-6860-6135","observed_orcids":["https://orcid.org/0000-0002-6860-6135","https://orcid.org/0000-0002-8267-1275","https://orcid.org/0009-0000-0571-6022"]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":["Department of Nutrition and Food Science, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, 1 Dali Road, Tianjin 300050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Science, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, 1 Dali Road, Tianjin 300050, China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042385698","display_name":"Shi Jun Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shi Jun Lu","raw_affiliation_strings":["Department of Nutrition and Food Science, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, 1 Dali Road, Tianjin 300050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Science, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, 1 Dali Road, Tianjin 300050, China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027545352","display_name":"Wan Qi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wan Qi Zhang","raw_affiliation_strings":["Department of Nutrition and Food Security, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Tianjin 300070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Security, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Tianjin 300070, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103588842","display_name":"Yu Gang Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Gang Jiang","raw_affiliation_strings":["Department of Nutrition and Food Science, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, 1 Dali Road, Tianjin 300050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Science, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, 1 Dali Road, Tianjin 300050, China","institution_ids":["https://openalex.org/I2802541053"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5905,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.80857159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"27","issue":"3","first_page":"186","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13446","display_name":"Antioxidants, Aging, Portulaca oleracea","score":0.7860999703407288,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13446","display_name":"Antioxidants, Aging, Portulaca oleracea","score":0.7860999703407288,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.1695999950170517,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.030799999833106995,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyanidin-3-o-galactoside","display_name":"cyanidin-3-O-galactoside","score":0.9929999709129333},{"id":"https://openalex.org/keywords/blueberry-extract","display_name":"blueberry extract","score":0.8939999938011169},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"spatial memory","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8859999775886536},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9459999799728394},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6510000228881836},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.42399999499320984},{"id":"https://openalex.org/keywords/cognitive-aging","display_name":"cognitive aging","score":0.6069999933242798},{"id":"https://openalex.org/keywords/samp8-mice","display_name":"SAMP8 mice","score":0.8209999799728394},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6859999895095825},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.7200000286102295},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9070000052452087},{"id":"https://openalex.org/keywords/passive-avoidance","display_name":"passive avoidance","score":0.4009999930858612},{"id":"https://openalex.org/keywords/morris-water-maze","display_name":"Morris water maze","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.8123738765716553},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7633216381072998},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.6502200365066528},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5668233036994934},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5250332355499268},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4908219277858734},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4363977909088135},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.4291604459285736},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.42780473828315735},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41211050748825073},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39240050315856934},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29134148359298706},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2907143235206604},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2855257987976074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27859973907470703},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27251285314559937},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.26097965240478516}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000872","descriptor_name":"Anthocyanins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001362","descriptor_name":"Avoidance Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005697","descriptor_name":"Galactosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029798","descriptor_name":"Blueberry Plants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:24709099","doi":"https://doi.org/10.3967/bes2014.007","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24709099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical and environmental sciences : BES","raw_type":"Journal Article"},{"id":"mag:2186115486","doi":"https://doi.org/10.3967/bes2014.007","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24709099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:3151940172","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/qk/84046X/201403/49286206.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306555121","display_name":"\u751f\u7269\u533b\u5b66\u4e0e\u73af\u5883\u79d1\u5b66\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u751f\u7269\u533b\u5b66\u4e0e\u73af\u5883\u79d1\u5b66\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W48640801","https://openalex.org/W1503820644","https://openalex.org/W1783307413","https://openalex.org/W1965926538","https://openalex.org/W1967441301","https://openalex.org/W1968286822","https://openalex.org/W1969570348","https://openalex.org/W1970411347","https://openalex.org/W1971945804","https://openalex.org/W1972980696","https://openalex.org/W1974115860","https://openalex.org/W1977575797","https://openalex.org/W1978733364","https://openalex.org/W1983781150","https://openalex.org/W1986211383","https://openalex.org/W1988008790","https://openalex.org/W2008004330","https://openalex.org/W2009670021","https://openalex.org/W2010603435","https://openalex.org/W2014136761","https://openalex.org/W2015331364","https://openalex.org/W2015872365","https://openalex.org/W2016970753","https://openalex.org/W2017593938","https://openalex.org/W2024107140","https://openalex.org/W2042058876","https://openalex.org/W2043439613","https://openalex.org/W2044452800","https://openalex.org/W2048534671","https://openalex.org/W2054052705","https://openalex.org/W2057716397","https://openalex.org/W2063303783","https://openalex.org/W2063490858","https://openalex.org/W2065814742","https://openalex.org/W2072039135","https://openalex.org/W2084947588","https://openalex.org/W2086676353","https://openalex.org/W2086950283","https://openalex.org/W2092340502","https://openalex.org/W2094074071","https://openalex.org/W2094474853","https://openalex.org/W2095224911","https://openalex.org/W2096573687","https://openalex.org/W2108647075","https://openalex.org/W2108791332","https://openalex.org/W2113055411","https://openalex.org/W2113092554","https://openalex.org/W2126086549","https://openalex.org/W2129678592","https://openalex.org/W2134873827","https://openalex.org/W2135287265","https://openalex.org/W2138605034","https://openalex.org/W2148689795","https://openalex.org/W2162968992","https://openalex.org/W2169473035","https://openalex.org/W2170836456","https://openalex.org/W2604544073","https://openalex.org/W3021585222"],"related_works":["https://openalex.org/W2326819638","https://openalex.org/W2094074071","https://openalex.org/W16984911","https://openalex.org/W2389755173","https://openalex.org/W2375378454","https://openalex.org/W2072039135","https://openalex.org/W2085926435","https://openalex.org/W2029585919","https://openalex.org/W2085488121","https://openalex.org/W1988819044"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"whether":[3],"the":[4,7,10,21,99,125,159,167,171,181,207,215,223],"antioxidation":[5],"and":[6,43,52,81,98,108,123,131,138,145,147,170,180,195,211],"regulation":[8],"on":[9,26,87,199],"Extracellular":[11],"Regulated":[12],"Protein":[13],"Kinases":[14],"(ERK)":[15],"signaling":[16],"pathway":[17],"are":[18],"involved":[19],"in":[20,142,154,214],"protective":[22],"effects":[23],"of":[24,72,101,173,189,209,225],"blueberry":[25,48,58,109,132,196],"central":[27],"nervous":[28],"system.":[29],"METHODS:":[30],"30":[31],"Senescence-accelerated":[32],"mice":[33,37,64],"prone":[34],"8":[35,60],"(SAMP8)":[36],"were":[38,65,89,103,111,175,191],"divided":[39],"into":[40],"three":[41],"groups":[42],"treated":[44],"with":[45],"normal":[46],"diet,":[47],"extracts":[49,110,133,197,204],"(200":[50],"mg/kg\u2022bw/day)":[51,56],"cyaniding-3-O-galactoside":[53],"(Cy-3-GAL)":[54],"(50":[55],"from":[57],"for":[59,237],"weeks.":[61],"10":[62],"SAMR1":[63],"set":[66],"as":[67],"control":[68],"group.":[69],"The":[70],"capacity":[71,224],"spatial":[73],"memory":[74],"was":[75],"assessed":[76],"by":[77,177,193],"Passive":[78],"avoidance":[79,161],"task":[80,162],"Morris":[82,182],"water":[83],"maze.":[84],"Histological":[85],"analyses":[86],"hippocampus":[88],"completed.":[90],"Malondialdehyde":[91],"(MDA)":[92],"levels,":[93],"Superoxide":[94],"Dismutase":[95],"(SOD)":[96],"activity":[97,137],"expression":[100,153],"ERK":[102,151],"detected.":[104],"RESULTS:":[105],"Both":[106],"Cy-3-GAL":[107,130,178,194,230],"shown":[112],"effective":[113],"functions":[114],"to":[115],"relieve":[116],"cellular":[117],"injury,":[118],"improve":[119],"hippocampal":[120,149],"neurons":[121],"survival":[122],"inhibit":[124],"pyramidal":[126],"cell":[127],"layer":[128],"damage.":[129],"also":[134],"increased":[135,148],"SOD":[136],"reduced":[139],"MDA":[140],"content":[141],"brain":[143],"tissues":[144],"plasma,":[146],"phosphorylated":[150],"(p-ERK)":[152],"SAMP8":[155],"mice.":[156],"Further":[157],"more,":[158],"passive":[160],"test":[163,185],"showed":[164,186],"that":[165],"both":[166],"latency":[168,190],"time":[169],"number":[172],"errors":[174],"improved":[176],"treatment,":[179],"Water":[183],"Maze":[184],"significant":[187],"decreases":[188],"detected":[192],"treatment":[198],"day":[200],"4.":[201],"CONCLUSION:":[202],"Blueberry":[203],"may":[205,231],"reverse":[206],"declines":[208],"cognitive":[210],"behavioral":[212],"function":[213],"ageing":[216],"process":[217],"through":[218],"several":[219],"pathways,":[220],"including":[221],"enhancing":[222],"antioxidation,":[226],"altering":[227],"stress":[228],"signaling.":[229],"be":[232],"an":[233],"important":[234],"active":[235],"ingredient":[236],"these":[238],"biological":[239],"effects.":[240]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}