{"id":"https://openalex.org/W2186103443","doi":null,"title":"Hyperglycemia induced by subchronic co-administration of chlorpyrifos and lead in Wistar rats: Role of pancreatic lipoperoxidation and alleviating effect of vitamin C","display_name":"Hyperglycemia induced by subchronic co-administration of chlorpyrifos and lead in Wistar rats: Role of pancreatic lipoperoxidation and alleviating effect of vitamin C","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2186103443","mag":"2186103443"},"language":"en","primary_location":{"id":"mag:2186103443","doi":null,"is_oa":false,"landing_page_url":"http://abu.edu.ng/publications/2013-01-27-143824_6233.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764722800","display_name":"Biology and medicine","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Biology and medicine","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063368279","display_name":"Suleiman Folorunsho Ambali","orcid":"https://orcid.org/0000-0002-5396-1468","observed_orcids":["https://orcid.org/0000-0002-5396-1468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ambali SF","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075206702","display_name":"Khalil Abu Shuaib","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khalil Abu Shuaib","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073984035","display_name":"Richard E. Edeh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard E. Edeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054341591","display_name":"Muftau Shittu","orcid":"https://orcid.org/0000-0003-4212-5103","observed_orcids":["https://orcid.org/0000-0003-4212-5103"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muftau Shittu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4212-5103","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024620236","display_name":"Motunrayo Ganiyat Akande","orcid":"https://orcid.org/0000-0003-3305-9888","observed_orcids":["https://orcid.org/0000-0003-3305-9888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Motunrayo Ganiyat Akande","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3305-9888","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0347,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.77603743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"3","issue":"1","first_page":"0","last_page":"0"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.6660000085830688,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.6660000085830688,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.295199990272522,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chlorpyrifos","display_name":"chlorpyrifos","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lead","display_name":"lead","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9390000104904175},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9340000152587891},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8029999732971191},{"id":"https://openalex.org/keywords/glycogen","display_name":"glycogen","score":0.7870000004768372},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8579999804496765},{"id":"https://openalex.org/keywords/antioxidant-pretreatment","display_name":"antioxidant pretreatment","score":0.6690000295639038},{"id":"https://openalex.org/keywords/serum-glucose","display_name":"serum glucose","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.7614652514457703},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.5837436318397522},{"id":"https://openalex.org/C2780022331","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Vitamin C","level":2,"score":0.560977578163147},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5309345722198486},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5280148386955261},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5229530930519104},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5057384967803955},{"id":"https://openalex.org/C2778206080","wikidata":"https://www.wikidata.org/wiki/Q856775","display_name":"Corn oil","level":2,"score":0.5003037452697754},{"id":"https://openalex.org/C2776304672","wikidata":"https://www.wikidata.org/wiki/Q414915","display_name":"Chlorpyrifos","level":3,"score":0.46711429953575134},{"id":"https://openalex.org/C2777551382","wikidata":"https://www.wikidata.org/wiki/Q141180","display_name":"Vitamin E","level":3,"score":0.4441668391227722},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33337754011154175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14110681414604187},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12929165363311768},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.0797899067401886},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2186103443","doi":null,"is_oa":false,"landing_page_url":"http://abu.edu.ng/publications/2013-01-27-143824_6233.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764722800","display_name":"Biology and medicine","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Biology and medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Zero hunger","score":0.41260001063346863,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1516423097","https://openalex.org/W1532217964","https://openalex.org/W1538399032","https://openalex.org/W1599084717","https://openalex.org/W1775749144","https://openalex.org/W1901275661","https://openalex.org/W1952635888","https://openalex.org/W1965459772","https://openalex.org/W1970846833","https://openalex.org/W1974942838","https://openalex.org/W1980331088","https://openalex.org/W1998553637","https://openalex.org/W2003978628","https://openalex.org/W2010086727","https://openalex.org/W2033981805","https://openalex.org/W2035745394","https://openalex.org/W2039788380","https://openalex.org/W2044114699","https://openalex.org/W2045227229","https://openalex.org/W2048122175","https://openalex.org/W2050579843","https://openalex.org/W2050815672","https://openalex.org/W2051071203","https://openalex.org/W2063656978","https://openalex.org/W2065321982","https://openalex.org/W2067715785","https://openalex.org/W2075654139","https://openalex.org/W2081207865","https://openalex.org/W2082771374","https://openalex.org/W2086234598","https://openalex.org/W2086464883","https://openalex.org/W2088054149","https://openalex.org/W2096119759","https://openalex.org/W2097784879","https://openalex.org/W2098701756","https://openalex.org/W2103558449","https://openalex.org/W2108462699","https://openalex.org/W2111555768","https://openalex.org/W2125321964","https://openalex.org/W2135158711","https://openalex.org/W2137151882","https://openalex.org/W2140992272","https://openalex.org/W2147635153","https://openalex.org/W2150833698","https://openalex.org/W2152358204","https://openalex.org/W2155511074","https://openalex.org/W2159758267","https://openalex.org/W2160341367","https://openalex.org/W2160523164","https://openalex.org/W2160953928","https://openalex.org/W2167580473","https://openalex.org/W2170251226","https://openalex.org/W2186478900","https://openalex.org/W2291309362","https://openalex.org/W2315963369","https://openalex.org/W2729740518","https://openalex.org/W2946321688"],"related_works":["https://openalex.org/W2114992268","https://openalex.org/W2121866743","https://openalex.org/W4409444568","https://openalex.org/W2726520860","https://openalex.org/W2731978785","https://openalex.org/W2060055730","https://openalex.org/W7099277986","https://openalex.org/W2588141339","https://openalex.org/W2945364712","https://openalex.org/W1972358125"],"abstract_inverted_index":{"Studies":[0],"were":[1,46,54,66,75,95,118,132,141,151],"conducted":[2],"to":[3,192,218],"evaluate":[4],"the":[5,26,138,185,203],"role":[6],"of":[7,16,29,40,127,165,187,212],"pancreatic":[8],"lipoperoxidation":[9],"on":[10],"hyperglycemia":[11,204],"induced":[12,209],"by":[13,122,210],"subchronic":[14],"co-administration":[15,164],"chlorpyrifos":[17],"(CPF)":[18],"and":[19,25,84,102,109,134,148,155,167,172,175,190,205,214],"lead":[20,168],"(Pb)":[21],"in":[22,43,52,63,92],"Wistar":[23,34],"rats":[24,35,131],"ameliorative":[27],"effect":[28],"vitamin":[30,69,98,182,200],"C.":[31],"Forty":[32],"male":[33],"divided":[36],"into":[37],"4":[38],"groups":[39],"5":[41],"animals":[42],"each":[44],"group":[45,53,64,93],"used":[47],"for":[48,124,143,153],"this":[49],"study.":[50],"Rats":[51],"dosed":[55,67],"with":[56,68,97,105,181,199],"corn":[57],"oil":[58],"(2":[59],"ml/kg)":[60],"while":[61,90],"those":[62,91],"II":[65],"C":[70,99,183,201],"(100":[71,100],"mg/kg).":[72],"Group":[73],"III":[74],"co-administered":[76,104],"CPF":[77,106,166,213],"(":[78],"4.25":[79],"mg/kg~":[80],"1/20":[81],"th":[82,88],"LD50)":[83,89],"Pb":[85,110,215],"(250":[86,111],"mg/kg~1/20":[87],"IV":[94],"pretreated":[96],"mg/kg)":[101,108,112],"then":[103],"(4.25":[107],"30":[113],"min":[114],"later.":[115],"The":[116,130,146,160],"regimen":[117],"administered":[119],"once":[120],"daily":[121],"gavage":[123],"a":[125,176],"period":[126],"9":[128],"weeks.":[129],"sacrificed":[133],"serum":[135],"obtained":[136],"from":[137],"blood":[139],"samples":[140,150],"analyzed":[142,152],"glucose":[144,171],"concentration.":[145,179],"liver":[147],"pancreas":[149],"glycogen":[154,178,189,207],"malonaldehyde":[156],"(MDA)":[157],"concentrations,":[158,174],"respectively.":[159],"study":[161],"showed":[162],"that":[163],"caused":[169],"increased":[170],"MDA":[173,191],"reduced":[177,206],"Pretreatment":[180],"restored":[184,202],"concentrations":[186],"glucose,":[188],"apparently":[193],"normal":[194],"level.":[195],"In":[196],"conclusion,":[197],"pretreatment":[198],"concentration":[208],"coadministration":[211],"partly":[216],"due":[217],"its":[219],"antioxidant":[220],"properties.":[221]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}