{"id":"https://openalex.org/W2186102474","doi":null,"title":"Effect of trichosanthin on apoptosis and telomerase activity of nasopharyngeal carcinomas in nude mice.","display_name":"Effect of trichosanthin on apoptosis and telomerase activity of nasopharyngeal carcinomas in nude mice.","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W2186102474","mag":"2186102474","pmid":"https://pubmed.ncbi.nlm.nih.gov/24065482"},"language":"en","primary_location":{"id":"pmid:24065482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24065482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of B.U.ON. : official journal of the Balkan Union of Oncology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037631027","display_name":"Min Kang","orcid":"https://orcid.org/0000-0003-2287-8757","observed_orcids":["https://orcid.org/0000-0003-2287-8757"]},"institutions":[{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Kang","raw_affiliation_strings":["Department of Radiology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I4210126060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111967731","display_name":"Hesheng Ou","orcid":"https://orcid.org/0000-0001-9708-8384","observed_orcids":["https://orcid.org/0000-0001-9708-8384"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hesheng Ou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059798382","display_name":"Rensheng Wang","orcid":"https://orcid.org/0000-0002-0768-9344","observed_orcids":["https://orcid.org/0000-0002-0768-9344","https://orcid.org/0000-0002-5010-3855"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rensheng Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100743530","display_name":"Wenqi Liu","orcid":"https://orcid.org/0000-0002-7917-3208","observed_orcids":["https://orcid.org/0000-0002-7917-3208"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenqi Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052925716","display_name":"Yan Mao","orcid":"https://orcid.org/0000-0003-0440-1605","observed_orcids":["https://orcid.org/0000-0003-0440-1605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Mao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004197882","display_name":"Anzhou Tang","orcid":"https://orcid.org/0000-0002-9717-5418","observed_orcids":["https://orcid.org/0000-0002-9717-5418"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anzhou Tang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8629,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.70300548,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"18","issue":"3","first_page":"675","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.03350000083446503,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trichosanthin","display_name":"trichosanthin","score":1.0},{"id":"https://openalex.org/keywords/nasopharyngeal-carcinoma","display_name":"nasopharyngeal carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/telomerase-activity","display_name":"telomerase activity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.890999972820282},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":1.0},{"id":"https://openalex.org/keywords/cne1-cells","display_name":"CNE1 cells","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cne2-cells","display_name":"CNE2 cells","score":1.0},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9079999923706055},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.796999990940094},{"id":"https://openalex.org/keywords/anticancer-effects","display_name":"anticancer effects","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.8897716999053955},{"id":"https://openalex.org/C2778997737","wikidata":"https://www.wikidata.org/wiki/Q1693598","display_name":"Nasopharyngeal carcinoma","level":3,"score":0.8449513912200928},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7288291454315186},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.5422637462615967},{"id":"https://openalex.org/C2780278673","wikidata":"https://www.wikidata.org/wiki/Q476743","display_name":"Nude mouse","level":3,"score":0.49620872735977173},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4789988696575165},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45470768213272095},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45275402069091797},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44034165143966675},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.43256473541259766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3746427893638611},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20291665196418762},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1914045810699463},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06679236888885498},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077274","descriptor_name":"Nasopharyngeal Carcinoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015978","descriptor_name":"Trichosanthin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24065482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24065482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of B.U.ON. : official journal of the Balkan Union of Oncology","raw_type":"Journal Article"},{"id":"mag:2186102474","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24065482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W636501739","https://openalex.org/W1796664015","https://openalex.org/W1965827401","https://openalex.org/W1968498761","https://openalex.org/W1977605192","https://openalex.org/W1998335196","https://openalex.org/W2002556927","https://openalex.org/W2005876906","https://openalex.org/W2014414194","https://openalex.org/W2020830322","https://openalex.org/W2026264079","https://openalex.org/W2030147142","https://openalex.org/W2033685251","https://openalex.org/W2035499819","https://openalex.org/W2042377388","https://openalex.org/W2055278015","https://openalex.org/W2062807002","https://openalex.org/W2063271191","https://openalex.org/W2077904082","https://openalex.org/W2080373915","https://openalex.org/W2080486351","https://openalex.org/W2089913110","https://openalex.org/W2090545675","https://openalex.org/W2099788715","https://openalex.org/W2105348435","https://openalex.org/W2106787323","https://openalex.org/W2127459809","https://openalex.org/W2135109846","https://openalex.org/W2160179156","https://openalex.org/W2169455407","https://openalex.org/W2171887423","https://openalex.org/W2356301463","https://openalex.org/W2380033097","https://openalex.org/W2502877236","https://openalex.org/W2514393632"],"related_works":["https://openalex.org/W2084697906","https://openalex.org/W2394121191","https://openalex.org/W2374236525","https://openalex.org/W2374815242","https://openalex.org/W2359071172","https://openalex.org/W2374180258","https://openalex.org/W2380033097","https://openalex.org/W2363552897","https://openalex.org/W2385807921","https://openalex.org/W4280648414"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"evaluate":[2],"the":[3,57,89,100,109,121,138,143],"effect":[4],"of":[5,54,72,81,111,123,145,160,168],"trichosanthin":[6],"(TCS)":[7],"on":[8],"telomerase":[9,93,169],"activity":[10,94],"and":[11,27,48,56,74,83,92,114,126,147],"apoptosis":[12,161],"in":[13,151],"nasopharyngeal":[14,29],"carcinoma":[15,30],"cells":[16,85,129,149],"implanted":[17,24],"into":[18,36],"nude":[19],"mice.":[20],"METHODS:":[21],"Nude":[22],"mice":[23,55],"with":[25,45,99,137,158,166],"CNE1":[26,82,113,125,146],"CNE2":[28,84,115,127,148],"cell":[31],"lines":[32,150],"were":[33,60,65,76,156],"randomly":[34],"divided":[35],"3":[37],"groups,":[38],"including":[39],"TCS":[40,106,141],"group,":[41],"control":[42,102],"group":[43,103],"(treatment":[44],"saline":[46],"only),":[47],"cyclophosphamide":[49],"(CTX)":[50],"group.":[51],"The":[52,62],"weight":[53],"tumor":[58,116,128],"volume":[59],"measured.":[61],"ultra-microstructural":[63],"changes":[64],"observed":[66],"by":[67,78,88,95],"transmission":[68],"electron":[69],"microscope.":[70],"Expression":[71],"Bcl-2":[73],"Bax":[75],"investigated":[77],"immunohistochemistry.":[79],"Apoptosis":[80],"was":[86,133],"determined":[87],"TUNEL":[90],"method,":[91],"TRAP-ELISA.":[96],"RESULTS:":[97],"Compared":[98],"normal":[101],"(saline":[104],"group),":[105],"significantly":[107],"inhibited":[108,120],"growth":[110,122,144],"both":[112,124],"cells.":[117],"CTX":[118],"also":[119],"but":[130],"this":[131],"inhibition":[132],"slightly":[134],"slower":[135],"compared":[136],"TCS.":[139],"CONCLUSION:":[140],"suppresses":[142],"vivo.":[152],"Its":[153],"anticancer":[154],"effects":[155],"associated":[157],"induction":[159],"and,":[162],"at":[163],"least":[164],"partially,":[165],"suppression":[167],"activity.":[170]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
