{"id":"https://openalex.org/W2186026432","doi":null,"title":"Effect of Ebselen on Noise Induced Cochlear Damage","display_name":"Effect of Ebselen on Noise Induced Cochlear Damage","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2186026432","mag":"2186026432"},"language":"en","primary_location":{"id":"mag:2186026432","doi":null,"is_oa":false,"landing_page_url":"http://journal.kisep.com/pdf/001/2005/0012005225.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210190137","display_name":"Korean Journal of Otorhinolaryngology - Head and Neck Surgery","issn_l":"1225-035X","issn":["1225-035X","2092-5859","2092-6529"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319531","host_organization_name":"Korean Society of Otorhinolaryngology-Head and Neck Surgery","host_organization_lineage":["https://openalex.org/P4310319531"],"host_organization_lineage_names":["Korean Society of Otorhinolaryngology-Head and Neck Surgery"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Korean Journal of Otorhinolaryngology-head and Neck Surgery","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017719573","display_name":"Yong\u2010Ho Park","orcid":"https://orcid.org/0000-0003-2106-3791","observed_orcids":["https://orcid.org/0000-0003-2106-3791"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong\u2010Ho Park","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2106-3791","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088167495","display_name":"Yong Won Lee","orcid":"https://orcid.org/0000-0002-6174-3479","observed_orcids":["https://orcid.org/0000-0002-6174-3479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Won Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6174-3479","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101588094","display_name":"Seok Won Park","orcid":"https://orcid.org/0000-0002-7522-2594","observed_orcids":["https://orcid.org/0000-0002-7522-2594"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seok Won Park","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7522-2594","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055048036","display_name":"Bon Seok Koo","orcid":"https://orcid.org/0000-0002-5928-0006","observed_orcids":["https://orcid.org/0000-0002-5928-0006"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bon Seok Koo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5928-0006","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100727673","display_name":"Yong Min Kim","orcid":"https://orcid.org/0000-0001-5414-8332","observed_orcids":["https://orcid.org/0000-0001-5414-8332","https://orcid.org/0000-0002-7054-8552","https://orcid.org/0000-0002-0523-4290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Min Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5414-8332","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084102615","display_name":"Ki\u2010Sang Rha","orcid":"https://orcid.org/0000-0001-9981-057X","observed_orcids":["https://orcid.org/0000-0001-9981-057X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ki\u2010Sang Rha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":94},"biblio":{"volume":"48","issue":"10","first_page":"1211","last_page":"1218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11692","display_name":"Noise Effects and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3102","display_name":"Acoustics and Ultrasonics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ebselen","display_name":"ebselen","score":1.0},{"id":"https://openalex.org/keywords/noise-induced-hearing-loss","display_name":"noise-induced hearing loss","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.8090000152587891},{"id":"https://openalex.org/keywords/free-radical-scavengers","display_name":"radical scavengers","score":0.9229999780654907},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.8069999814033508},{"id":"https://openalex.org/keywords/3-nitrotyrosine","display_name":"nitrotyrosine","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.800000011920929},{"id":"https://openalex.org/keywords/organ-of-corti","display_name":"organ of Corti","score":0.8240000009536743},{"id":"https://openalex.org/keywords/spiral-ganglion","display_name":"spiral ganglion","score":0.8840000033378601},{"id":"https://openalex.org/keywords/stria-vascularis","display_name":"stria vascularis","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C2779138974","wikidata":"https://www.wikidata.org/wiki/Q5332073","display_name":"Ebselen","level":5,"score":0.9656065702438354},{"id":"https://openalex.org/C2779152698","wikidata":"https://www.wikidata.org/wiki/Q3095145","display_name":"Spiral ganglion","level":3,"score":0.8465588688850403},{"id":"https://openalex.org/C2780130748","wikidata":"https://www.wikidata.org/wiki/Q317857","display_name":"Cochlea","level":2,"score":0.834165096282959},{"id":"https://openalex.org/C2780659331","wikidata":"https://www.wikidata.org/wiki/Q1128309","display_name":"Organ of Corti","level":3,"score":0.8273108601570129},{"id":"https://openalex.org/C2779385521","wikidata":"https://www.wikidata.org/wiki/Q412383","display_name":"Nitrotyrosine","level":4,"score":0.5898644924163818},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.5778778791427612},{"id":"https://openalex.org/C43791021","wikidata":"https://www.wikidata.org/wiki/Q608256","display_name":"Auditory brainstem response","level":3,"score":0.47334861755371094},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.47113651037216187},{"id":"https://openalex.org/C2992339995","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Free radical scavenger","level":3,"score":0.4523490369319916},{"id":"https://openalex.org/C2778585322","wikidata":"https://www.wikidata.org/wiki/Q1566641","display_name":"Hair cell","level":3,"score":0.42198583483695984},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.4118667542934418},{"id":"https://openalex.org/C2779356876","wikidata":"https://www.wikidata.org/wiki/Q1475712","display_name":"Noise-induced hearing loss","level":4,"score":0.41012927889823914},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3974651098251343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37803858518600464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3409382700920105},{"id":"https://openalex.org/C3018332767","wikidata":"https://www.wikidata.org/wiki/Q4117845","display_name":"Noise exposure","level":3,"score":0.274100661277771},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.2730247378349304},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2432667315006256},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.20361441373825073},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.1507897675037384},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.08592742681503296}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2186026432","doi":null,"is_oa":false,"landing_page_url":"http://journal.kisep.com/pdf/001/2005/0012005225.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210190137","display_name":"Korean Journal of Otorhinolaryngology - Head and Neck Surgery","issn_l":"1225-035X","issn":["1225-035X","2092-5859","2092-6529"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319531","host_organization_name":"Korean Society of Otorhinolaryngology-Head and Neck Surgery","host_organization_lineage":["https://openalex.org/P4310319531"],"host_organization_lineage_names":["Korean Society of Otorhinolaryngology-Head and Neck Surgery"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Korean Journal of Otorhinolaryngology-head and Neck Surgery","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W183069189","https://openalex.org/W236135089","https://openalex.org/W1507112934","https://openalex.org/W1978156415","https://openalex.org/W1978284525","https://openalex.org/W1979769805","https://openalex.org/W1985499785","https://openalex.org/W2000540296","https://openalex.org/W2027107445","https://openalex.org/W2034702811","https://openalex.org/W2035258484","https://openalex.org/W2049478302","https://openalex.org/W2075639702","https://openalex.org/W2075910499","https://openalex.org/W2087982528","https://openalex.org/W2107442441","https://openalex.org/W2114557855","https://openalex.org/W2154265438","https://openalex.org/W2437174840"],"related_works":["https://openalex.org/W1978284525","https://openalex.org/W2114557855","https://openalex.org/W2040756940","https://openalex.org/W2050666593","https://openalex.org/W2156301705","https://openalex.org/W2736124908","https://openalex.org/W2017236142","https://openalex.org/W2917140717","https://openalex.org/W2100094024","https://openalex.org/W2020372897"],"abstract_inverted_index":{"Background":[0],"and":[1,8,62,100,120,150,166,173],"Objectives:With":[2],"the":[3,13,46,124,132,160,178,184],"advancement":[4],"of":[5,11,16,40,48,148,159,162,171,199],"modern":[6],"civilization":[7],"mechanical":[9],"development":[10],"society,":[12],"pre-":[14],"valence":[15],"noise-induced":[17,27,58],"hearing":[18,28],"loss":[19,29],"is":[20,43],"increasing.":[21],"There":[22],"were":[23,78,93,114,152,175],"some":[24],"suggestions":[25],"that":[26,139],"may":[30],"be":[31],"reduced":[32,142],"or":[33,55],"prevented":[34],"with":[35,71],"antioxidant":[36,56],"treatment.":[37],"The":[38,146,169],"purpose":[39],"this":[41],"study":[42,117],"to":[44,83],"evaluate":[45],"effect":[47],"ebselen":[49,92,140,179],"as":[50,196],"a":[51,194,197],"free":[52],"radical":[53],"scavenger":[54,198],"in":[57,123,154,177,183],"cochlear":[59],"damage.":[60],"Materials":[61],"Method:Thirty":[63],"male":[64],"Sprague":[65],"Dawley":[66],"rats":[67],"(250-":[68],"300":[69],"g":[70],"normal":[72],"auditory":[73,108,135],"brainstem":[74,136],"response":[75,111],"(ABR":[76],"thresholds":[77],"exposed":[79],"for":[80,118],"6":[81],"h":[82,98],"115":[84],"dB":[85],"SPL":[86],"broad":[87],"band":[88],"noise.":[89],"10":[90],"mg/kg":[91],"injected":[94],"intraperitoneally":[95],"at":[96],"12":[97],"before":[99,102],"1h":[101],"noise":[103,106,133,191],"exposure.":[104],"After":[105],"exposure,":[107,134],"brain-":[109],"stem":[110],"threshold":[112,143],"shifts":[113,144],"evaluated.":[115],"A":[116],"iNOS":[119,149,172],"nitrotyrosine":[121,151,174],"expressions":[122],"cochlea":[125,189],"was":[126],"examined":[127],"by":[128,192],"immunohistochemical":[129],"staining.":[130],"Results:After":[131],"responses":[137],"indicated":[138],"treatment":[141],"significantly.":[145],"expression":[147,170],"observed":[153],"hair":[155],"cells,":[156],"supporting":[157],"cells":[158],"organ":[161],"Corti,":[163],"stria":[164],"vascularis":[165],"spiral":[167],"ganglion.":[168],"lower":[176],"treated":[180],"group":[181],"than":[182],"non-treated":[185],"group.":[186],"Conclusion:Ebselen":[187],"protects":[188],"from":[190],"playing":[193],"role":[195],"reactive":[200]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
