{"id":"https://openalex.org/W2185990083","doi":null,"title":"Clinical significance of Vascular Endothelial Growth Factor in Egyptian colorectal cancer patients","display_name":"Clinical significance of Vascular Endothelial Growth Factor in Egyptian colorectal cancer patients","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2185990083","mag":"2185990083"},"language":"en","primary_location":{"id":"mag:2185990083","doi":null,"is_oa":false,"landing_page_url":"http://www.classicrus.com/IJIB/Arch/2008/1108.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021010432","display_name":"Mie Afify","orcid":"https://orcid.org/0000-0002-3187-1322","observed_orcids":["https://orcid.org/0000-0002-3187-1322"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mie Afify","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3187-1322","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063568927","display_name":"Nervana Samy","orcid":"https://orcid.org/0000-0003-3348-7647","observed_orcids":["https://orcid.org/0000-0003-3348-7647"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nervana Samy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3348-7647","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046034920","display_name":"Maha Hashim","orcid":"https://orcid.org/0000-0002-0868-0181","observed_orcids":["https://orcid.org/0000-0002-0868-0181"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maha Hashim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0868-0181","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5083653621","display_name":"Tarek Essam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tarek Essam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9929999709129333},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9710000157356262},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.6710000038146973},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.9039999842643738},{"id":"https://openalex.org/keywords/ca19-9","display_name":"CA19-9","score":0.9649999737739563},{"id":"https://openalex.org/keywords/vegf-isoforms","display_name":"VEGF isoforms","score":0.8080000281333923},{"id":"https://openalex.org/keywords/vegf165","display_name":"VEGF165","score":0.9679999947547913},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.75},{"id":"https://openalex.org/keywords/tumor-burden","display_name":"tumor burden","score":0.6119999885559082},{"id":"https://openalex.org/keywords/curative-surgery","display_name":"curative surgery","score":0.593999981880188},{"id":"https://openalex.org/keywords/egyptian-patients","display_name":"Egyptian patients","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2777387746","wikidata":"https://www.wikidata.org/wiki/Q769706","display_name":"Carcinoembryonic antigen","level":3,"score":0.825002908706665},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8247106075286865},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7943500280380249},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.7224339246749878},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6486732959747314},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5443874597549438},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5376812815666199},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.518782377243042},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.4820340871810913},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.45186761021614075},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4179995656013489},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.386023610830307},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.21195268630981445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09281376004219055},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2185990083","doi":null,"is_oa":false,"landing_page_url":"http://www.classicrus.com/IJIB/Arch/2008/1108.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W179052392","https://openalex.org/W1518855137","https://openalex.org/W1832582024","https://openalex.org/W1923484756","https://openalex.org/W1969026343","https://openalex.org/W1994054543","https://openalex.org/W1995863484","https://openalex.org/W2002983094","https://openalex.org/W2003632052","https://openalex.org/W2017352677","https://openalex.org/W2018467818","https://openalex.org/W2019008551","https://openalex.org/W2026203259","https://openalex.org/W2043103956","https://openalex.org/W2049408374","https://openalex.org/W2050499474","https://openalex.org/W2050888224","https://openalex.org/W2057965634","https://openalex.org/W2061818636","https://openalex.org/W2065200638","https://openalex.org/W2083867249","https://openalex.org/W2088220946","https://openalex.org/W2093899735","https://openalex.org/W2112102866","https://openalex.org/W2119302106","https://openalex.org/W2145097136","https://openalex.org/W2147218938","https://openalex.org/W2160394568","https://openalex.org/W2164621617","https://openalex.org/W2317487953","https://openalex.org/W2397524040","https://openalex.org/W2408391487","https://openalex.org/W2430980540","https://openalex.org/W2474109925"],"related_works":["https://openalex.org/W2474109925","https://openalex.org/W2354764961","https://openalex.org/W2412618232","https://openalex.org/W7097160043","https://openalex.org/W2105524916","https://openalex.org/W2978688379","https://openalex.org/W1990212098","https://openalex.org/W2061818636","https://openalex.org/W2303346607","https://openalex.org/W7171529165"],"abstract_inverted_index":{"Angiogenesis":[0],"represents":[1],"an":[2,42],"essential":[3],"step":[4],"in":[5,47,78,81,111,147,163,214,217,227,235,261,279],"tumor":[6,265,280,307],"proliferation,":[7],"expansion,":[8],"and":[9,58,90,102,139,194,203,210,224,264,282,309,345],"metastasis.":[10],"Among":[11],"angiogenic":[12],"molecules,":[13],"vascular":[14,103],"endothelial":[15,104],"growth":[16,105],"factor":[17,106],"(VEGF)":[18],"appears":[19],"to":[20,32,59,83,153,290],"have":[21],"a":[22,125,170,245,333,341],"central":[23],"role..":[24],"The":[25],"objective":[26],"of":[27,37,44,75,208,233,254,267,272,285,313,336,343],"the":[28,34,71,84,175,218,270,283,286,311],"current":[29],"study":[30,129,295],"was":[31,109,239,249,259,274],"assess":[33],"prognostic":[35],"significance":[36],"VEGF":[38,76,157,191,209,234,292,300,319,337],"plasma":[39,92,158,192,291,299,320],"level":[40,321],"as":[41,124,325,332],"indicator":[43,326],"recurrent":[45,328],"disease":[46,64],"patients":[48,113,148,164],"with":[49,55,63,114,149,169,229,251],"colorectal":[50,79,115,150,236,314],"carcinoma":[51,151],"scheduled":[52,117],"for":[53,118,306,327],"surgery":[54],"curative":[56,167],"intent,":[57],"determine":[60],"its":[61],"relationship":[62],"stage":[65],"at":[66,276],"presentation.":[67],"Also,":[68,317],"we":[69],"studied":[70],"protein":[72,247],"expression":[73,108,271,338],"pattern":[74],"isoforms":[77],"tumors":[80],"comparison":[82,228],"corresponding":[85],"adjacent":[86],"normal":[87,263,344],"tissues.":[88],"Preoperative":[89],"postoperative":[91,178],"VEGF,":[93,133],"Serum":[94],"CEA,":[95],"CA19-9":[96],"levels":[97,143,159,193,278],"were":[98,144,160],"determined":[99],"by":[100,241,340],"ELISA":[101],"Protein":[107],"detected":[110,250,275],"78":[112],"cancer":[116,237,315],"surgery.":[119],"Fifty":[120],"healthy":[121],"individuals":[122],"served":[123],"control":[126,154],"group.":[127,155],"This":[128,294],"showed":[130],"that":[131,297],"preoperative":[132,190,298],"carbohydrate":[134],"antigen":[135,141],"19.9":[136],"(CA":[137],"19-9)":[138],"carcinoembryonic":[140],"(CEA)":[142],"significantly":[145,161],"high":[146],"compared":[152],"Moreover,":[156],"lowered":[162],"who":[165],"underwent":[166],"surgery,":[168],"further":[171],"downward":[172],"trend":[173],"until":[174],"6":[176],"month":[177],"(P":[179],"<0.05).":[180],"Multiple":[181],"regression":[182],"analysis":[183],"demonstrated":[184],"significant":[185,215],"positive":[186,220],"correlation":[187],"(r)":[188],"between":[189],"Dukes":[195],"stages,":[196,198],"TNM":[197],"T":[199],"classes,":[200],"CEA":[201,211,230],"levels,":[202],"CA":[204],"19-9":[205],"(P<0.05).":[206],"Combining":[207],"markers":[212],"result":[213],"increase":[216],"specificity,":[219],"predictive":[221],"value":[222],"(PPV)":[223],"accuracy":[225],"(P<0.05)":[226],"alone.":[231],"Over-expression":[232],"tissue":[238],"confirmed":[240],"western":[242],"blot":[243],"(WB);":[244],"main":[246],"band":[248],"molecular":[252],"weight":[253],"23":[255],"kDa":[256],"(VEGF165),":[257],"which":[258],"expressed":[260],"both":[262],"tissues":[266,281],"colorectal,":[268],"but":[269],"VEGF165":[273],"higher":[277],"intensities":[284],"bands":[287],"varied":[288],"according":[289],"concentrations.":[293],"revealed":[296],"concentrations":[301],"might":[302],"be":[303,323],"valuable":[304],"parameter":[305],"burden":[308],"predicting":[310],"outcome":[312],"patients.":[316],"post-operative":[318],"can":[322],"considered":[324,331],"disease.":[329],"VEGF165,":[330],"predominant":[334],"form":[335],"secreted":[339],"variety":[342],"transformed":[346],"cells.":[347]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}