{"id":"https://openalex.org/W2185879944","doi":null,"title":"Antiviral Warrior\u2014APOBEC3G","display_name":"Antiviral Warrior\u2014APOBEC3G","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2185879944","mag":"2185879944"},"language":"zh","primary_location":{"id":"mag:2185879944","doi":null,"is_oa":false,"landing_page_url":"https://www.ccs.asia.edu.tw/ezfiles/2/1002/img/516/0504-19.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306542035","display_name":"\u4e2d\u56fd\u7535\u5b50\u79d1\u6280\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u7535\u5b50\u79d1\u6280(\u82f1\u6587\u7248)","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108576428","display_name":"WU Xiao-xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wu .","raw_affiliation_strings":["School of Life Science and Technology, University of Electronic Science and Technology of China, ChengDu 610054, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, University of Electronic Science and Technology of China, ChengDu 610054, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153053879","display_name":"Xiaoxia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxia","raw_affiliation_strings":["School of Life Science and Technology, University of Electronic Science and Technology of China, ChengDu 610054, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, University of Electronic Science and Technology of China, ChengDu 610054, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153167948","display_name":"Ma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5153152795","display_name":"Yi-cai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi-cai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.15418502,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"4","first_page":"372","last_page":"376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apobec3g","display_name":"APOBEC3G","score":1.0},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.8579999804496765},{"id":"https://openalex.org/keywords/vif","display_name":"Vif","score":0.6290000081062317},{"id":"https://openalex.org/keywords/retroviral-restriction-factors","display_name":"retroviral restriction factors","score":0.6759999990463257},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.7820000052452087},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6449999809265137},{"id":"https://openalex.org/keywords/dna-editing","display_name":"DNA editing","score":0.5559999942779541},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.6439999938011169},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C2781310106","wikidata":"https://www.wikidata.org/wiki/Q14916265","display_name":"APOBEC3G","level":4,"score":0.9765951633453369},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6832011342048645},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6131756901741028},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5550207495689392},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.5281462669372559},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.5014586448669434},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4366976022720337},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4068242311477661},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.39156636595726013},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36600378155708313},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2562068700790405},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1544097661972046}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2185879944","doi":null,"is_oa":false,"landing_page_url":"https://www.ccs.asia.edu.tw/ezfiles/2/1002/img/516/0504-19.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306542035","display_name":"\u4e2d\u56fd\u7535\u5b50\u79d1\u6280\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u7535\u5b50\u79d1\u6280(\u82f1\u6587\u7248)","raw_type":null},{"id":"mag:3145138927","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/87980X/200504/21220036.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306542035","display_name":"\u4e2d\u56fd\u7535\u5b50\u79d1\u6280\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u7535\u5b50\u79d1\u6280\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1575305367","https://openalex.org/W1966343819","https://openalex.org/W1972739934","https://openalex.org/W1988594928","https://openalex.org/W1990993204","https://openalex.org/W1991069890","https://openalex.org/W1993897877","https://openalex.org/W2001375348","https://openalex.org/W2004640739","https://openalex.org/W2023035407","https://openalex.org/W2039773345","https://openalex.org/W2042486230","https://openalex.org/W2054437592","https://openalex.org/W2063337242","https://openalex.org/W2072011240","https://openalex.org/W2139033519","https://openalex.org/W2147059663","https://openalex.org/W2149643442","https://openalex.org/W2172100406","https://openalex.org/W2380986779"],"related_works":["https://openalex.org/W2390917093","https://openalex.org/W1604102076","https://openalex.org/W2040313539","https://openalex.org/W1977493885","https://openalex.org/W2330172665","https://openalex.org/W12694555","https://openalex.org/W1991069890","https://openalex.org/W4255017536","https://openalex.org/W2410713675","https://openalex.org/W2149138273"],"abstract_inverted_index":{"This":[0],"paper":[1],"is":[2,35,48,107,135],"to":[3,13,17,80,124,137],"further":[4],"understand":[5],"how":[6],"APOBEC3G":[7,31,70,81,89,106,117],"can":[8],"defend":[9,138],"the":[10,43,65,68,83,86,99,126],"retroviruses":[11,129,145],"and":[12,82,146],"find":[14],"new":[15],"approaches":[16],"AIDs":[18],"(acquired":[19],"immure":[20],"deficiency":[21],"syndrome).The":[22],"viral":[23],"infectivity":[24],"factor":[25],"(Vif)":[26],"induces":[27],"rapid":[28],"degradation":[29,87],"of":[30,54,67,88,111,128,142],"by":[32,90],"ubiquitination,":[33],"which":[34],"a":[36,55,61,91,108,139,151],"proteosome-dependent":[37],"pathway.":[38],"Precisely":[39],"speaking,":[40],"only":[41,119],"in":[42,50,121],"virus-producing":[44],"cell":[45,58],"Vif":[46,73,102],"expression":[47],"necessary;":[49],"its":[51],"absence,":[52],"infection":[53],"subsequent":[56],"target":[57],"terminates":[59],"at":[60],"postentry":[62],"step":[63],"through":[64,150],"action":[66],"human":[69],"antiviral":[71],"mechanism.":[72],"protein":[74],"has":[75,103],"two":[76],"domains:":[77],"one":[78],"binds":[79],"other":[84],"regulates":[85],"conserved":[92],"sequence,":[93],"SLQ":[94],"(Y/F)":[95],"LA":[96],"motif.":[97],"Recently,":[98],"research":[100],"on":[101],"also":[104,134],"revealed":[105],"novel":[109],"component":[110],"innate":[112],"immune":[113],"system.":[114],"In":[115],"fact,":[116],"not":[118],"acts":[120],"DNA":[122],"editing":[123],"block":[125],"replication":[127],"such":[130],"as":[131],"HIV-1,":[132],"but":[133],"able":[136],"wide":[140],"spectrum":[141],"distantly":[143],"related":[144],"interferes":[147],"with":[148],"HBV":[149],"different":[152],"mechanism":[153],"from":[154],"HIV.":[155]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}