{"id":"https://openalex.org/W2185836129","doi":null,"title":"MRI correlates of cognitive dysfunction in multiple sclerosis patients.","display_name":"MRI correlates of cognitive dysfunction in multiple sclerosis patients.","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2185836129","mag":"2185836129","pmid":"https://pubmed.ncbi.nlm.nih.gov/10871808"},"language":"en","primary_location":{"id":"pmid:10871808","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10871808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurovirology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059578809","display_name":"Marco Rovaris","orcid":"https://orcid.org/0000-0001-9691-1957","observed_orcids":["https://orcid.org/0000-0001-9691-1957"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Rovaris","raw_affiliation_strings":["Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, via Olgettina 60, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, via Olgettina 60, 20132 Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003010065","display_name":"Massimo Filippi","orcid":"https://orcid.org/0000-0002-5485-0479","observed_orcids":["https://orcid.org/0000-0002-5485-0479"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Filippi","raw_affiliation_strings":["IRCCS Ospedale San Raffaele"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Ospedale San Raffaele","institution_ids":["https://openalex.org/I4210133214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210133214"],"apc_list":null,"apc_paid":null,"fwci":0.8892,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.72562726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6 Suppl 2","issue":null,"first_page":"S172","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8700000047683716},{"id":"https://openalex.org/keywords/lesion-load","display_name":"lesion load","score":0.5789999961853027},{"id":"https://openalex.org/keywords/t2-weighted-mri","display_name":"T2-weighted MRI","score":0.7229999899864197},{"id":"https://openalex.org/keywords/magnetization-transfer-ratio","display_name":"magnetization transfer ratio","score":0.9549999833106995},{"id":"https://openalex.org/keywords/normal-appearing-white-matter","display_name":"normal-appearing white matter","score":0.878000020980835}],"concepts":[{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.8159449100494385},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.770232081413269},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6444768309593201},{"id":"https://openalex.org/C2777127467","wikidata":"https://www.wikidata.org/wiki/Q749520","display_name":"Frontal lobe","level":2,"score":0.6085885763168335},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5435412526130676},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5402491092681885},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.5303992033004761},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.5298435688018799},{"id":"https://openalex.org/C146638467","wikidata":"https://www.wikidata.org/wiki/Q10529587","display_name":"Hyperintensity","level":3,"score":0.5083093047142029},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4935678243637085},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4590981602668762},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45619186758995056},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43293437361717224},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.42759114503860474},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3629716634750366},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3542105257511139},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.14177155494689941},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09219443798065186}],"mesh":[{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:10871808","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10871808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurovirology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unisr.it:20.500.11768/2390","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11768/2390","pdf_url":null,"source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2185836129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10871808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1967440018","https://openalex.org/W1976149684","https://openalex.org/W1980261845","https://openalex.org/W1990755823","https://openalex.org/W2007090065","https://openalex.org/W2012637054","https://openalex.org/W2015052590","https://openalex.org/W2017381757","https://openalex.org/W2018293247","https://openalex.org/W2023180387","https://openalex.org/W2041731350","https://openalex.org/W2044316282","https://openalex.org/W2045762174","https://openalex.org/W2057512340","https://openalex.org/W2058784068","https://openalex.org/W2060129459","https://openalex.org/W2087422472","https://openalex.org/W2094940335","https://openalex.org/W2112165124","https://openalex.org/W2135142396","https://openalex.org/W2140885259","https://openalex.org/W2144276354","https://openalex.org/W2149953041","https://openalex.org/W2152317140","https://openalex.org/W2158796001","https://openalex.org/W2168406554","https://openalex.org/W2325038063","https://openalex.org/W2438170909"],"related_works":["https://openalex.org/W2414827863","https://openalex.org/W2018293247","https://openalex.org/W2007090065","https://openalex.org/W2001912039","https://openalex.org/W2043766171","https://openalex.org/W2061217252","https://openalex.org/W1966515025","https://openalex.org/W1921505795","https://openalex.org/W2488792835","https://openalex.org/W2079572731"],"abstract_inverted_index":{"Studies":[0],"with":[1,20,36,68],"conventional":[2],"magnetic":[3],"resonance":[4],"imaging":[5],"(MRI)":[6],"support":[7],"the":[8,21,37,43,52,73,81,91,120,125,130,133,142],"hypothesis":[9],"that":[10,113,140],"cognitive":[11,28,106],"impairment":[12],"in":[13,59,119],"multiple":[14],"sclerosis":[15],"(MS)":[16],"patients":[17],"is":[18],"related":[19,35],"lesion":[22,40,45,85],"burden.":[23],"Patterns":[24],"of":[25,51,76,83,94,122,127,132,141],"frontal":[26,61],"lobe":[27,62],"decline":[29],"were":[30],"also":[31],"found":[32],"to":[33,55,72,104],"be":[34,56],"corresponding":[38],"regional":[39],"load,":[41],"although":[42],"total":[44],"load":[46,86],"on":[47,87],"T2-weighted":[48],"MRI":[49,66],"scans":[50,89],"brain":[53],"seems":[54],"more":[57],"relevant":[58],"determining":[60],"deficits.":[63],"Other":[64],"non-conventional":[65],"techniques":[67],"a":[69,117],"higher":[70],"specificity":[71],"heterogeneous":[74],"substrates":[75],"MS":[77,105,123,128],"pathology,":[78],"such":[79],"as":[80],"assessment":[82],"hypointense":[84],"T1-weighted":[88],"and":[90,139],"histogram":[92],"analysis":[93],"magnetisation":[95],"transfer":[96],"ratio":[97],"(MTR)":[98],"maps,":[99],"have":[100],"recently":[101],"been":[102],"applied":[103],"studies.":[107],"Results":[108],"from":[109],"these":[110],"studies":[111],"suggest":[112],"three":[114],"factors":[115],"play":[116],"role":[118],"pathogenesis":[121],"dementia:":[124],"burden":[126],"lesions,":[129],"severity":[131],"pathological":[134],"damage":[135],"within":[136],"individual":[137],"lesions":[138],"normal-appearing":[143],"white":[144],"matter.":[145]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}